Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"gene profiling"”.
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PAX3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
… embryo. As a result of alternative splicing, the gene gives rise to eight different transcripts which encode proteins that have differing structures and are therefore likely to activate different downstream target genes. The presence of post-translational modifications has also been shown to alter …
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Transcriptomic and Secretomic Profiling of Isolated Leukocytes Exposed to Alpha-Particle and Photon Radiation - Applications in Biodosimetry
The general public is at risk of ionising-radiation exposure. The development of high-throughput methods to triage exposures is warranted. Current biodosimetry techniques are low-throughput and encumbered by time and technical expertise. Although there has been an emergence of gene-profiling tools …
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The Diversity of Cortical Interneurons
… this, cortical interneurons form a very heterogeneous group, making it hard to classify them without markers. We took a BACtrap approach performing translating ribosome affinity purifications on transgenic mice with Bacterial artificial chromosome, for systematic discovery of markers for …
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Transcriptional control of somatosensory neuron diversification in Drosophila
… peripheral nervous system to identify genetic and molecular programs that coordinate dendrite and axonal morphogenesis in individual sensory neurons. The homeodomain transcription factor Cut is expressed in neurons with complex dendrite morphologies that innervate the epidermis and …
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Investigation of Microbiota in Health and Disease of Poultry
… diseases of both humans and animals. 16S rRNA genes sequence analysis is one of the most popular and commonly used methods in the analysis of microbiotas associated with hosts. In this dissertation, the microbiotas of chickens (broilers, breeders, and layers) and turkeys were evaluated by 16S …
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Role of glucose transporter 1 during pregnancy
… in embryo implantation. Further studies using gene profiling has shown that Hif2α regulates Glucose transporter1 (GLUT1). GLUT1 is the dominant glucose transporter in the uterus and has been linked to human infertility. Based on these points, we chose to investigate the role of GLUT1 in …
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Neuronal Diversification Within the Retina: Generation of Crossed and Uncrossed Retinal Ganglion Cells
… and how they are induced by the patterning genes that set up the different domains in which these RGC subtypes reside. An even more elusive question within the field is how the ipsilateral and contralateral RGC subpopulations acquire their different cell fates. In this thesis, I present my …
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Estrogen signaling during decidualization
… that mediate the action of local E, we performed gene expression profiling, using decidual tissues obtained from mice treated with or without letrozole, a specific inhibitor to the key biosynthetic enzyme, cytochrome P450 aromatase. Of the number of molecules identified from the microarray …
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Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
During Drosophila oogenesis, a germline stem cell (GSC) divides asymmetrically to produce a renewed stem cell and a differentiated daughter cystoblast (CB) that will progress through the 14 stages of oogenesis to produce a mature egg. A myriad of factors regulate GSC maintenance; extrinsic signals …
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UNDERSTADING THE ROLE OF PSEUDOKINASE TRB3 IN CANCER PROGRESSION AND CHEMORESISTANCE DURING METABOLIC STRESS
… cell growth. The analysis of cell cycle gene profiling revealed a decrease in several genes that are essential for cell cycle progression in S phase in Trb3 overexpressed NCI-H358. The cell proliferation protein, Ki67, was also decreased in Trb3 overexpressed NCI-H358 cells. Moreover, Tb3 …
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The impact of hypoxia on out-of-field signalling responses following exposure to modulated irradiation
… have validated that hypoxic tumours result in genetic alterations which can allow a survival advantage and increase the tumorigenic properties of cancer cells. Additional understanding of the signalling responses in hypoxic microenvironments is therefore needed to optimise radiation treatment …
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SVILUPPO DI TECNICHE PER L'ISOLAMENTO, LA CARATTERIZZAZIONE E IL DIFFERENZIAMENTO DI CELLULE STAMINALI MESENCHIMALI PER UN USO IN MEDICINA RIGENERATIVA
… point of view by taking advantage of the regenerative properties of the stem cells, focusing especially on articulations and bones damages. The stem cells are a cell population physiologically involved in the processes of tissue repair and regeneration therefore would suit well with a …
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Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR
… zunächst versucht, die Spleißvariante als endogenes Protein zu detektieren. Dies gelang in Kulturen aus primären Schwannzellen. Wie zudem gezeigt wurde, ist diese Rezeptorisoform in einer in unserem Labor generierten Deletionsmutante von p75NTR nicht mehr vorhanden. Darüber hinaus wurde ein …
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Analisi integrata dell'espressione di geni/microrna in un modello di epatocancerogenesi sperimentale
… changes that lead to HCC, the molecular pathogenesis of HCC is not yet well understood. Gene expression studies conducted with microarray techniques and real-time PCR, suggest that tumors are characterized by an aberrant activation of signal transduction pathways involved in proliferation, …