Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"gene polymorphisms"”.
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Gene polymorphisms in SLE
… (SLE) is an autoimmune disease, with a strong genetic component. It is characterised by hyperactive T and B cells, chronic inflammation and the production of antinuclear autoantibodies. SLE affects mostly women of child baring age, with a 9:1 ratio, women to men and has been reported to be more …
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Characterisation Of Cytokine Gene Polymorphisms In Patients With Acute Pancreatitis
… are important mediators of disease pathogenesis. To investigate if the TNF and IL-10 gene loci influence susceptibility to and severity of acute pancreatitis, 135 patients with acute pancreatitis, ethnically matched normal controls, and alcoholics without pancreatic disease were studied. …
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Influence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Training
… to examine the influence of the FokI and BsmI polymorphisms of the vitamin D receptor gene on changes in insulin sensitivity with aerobic exercise training in men and women at increased risk for type 2 diabetes mellitus (T2DM). Subjects were genotyped and underwent oral glucose tolerance tests …
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
… was to study the occurrence of selected DNA polymorphisms in genes encoding the drug metabolism enzymes, mEH and GSTM in individuals affected with FHS, fetal hydantoin effects, oral clefts, congenital heart defect, and other major malformations associated with maternal phenytoin use during …
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CTLA4 gene polymorphisms in autoimmune hepatitis (AIH) : gene and clinical disease correlations in South African patients
Also available online. Includes bibliographical references (leaves 76-85).
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ASMT gene polymorphisms are associated with Autism Spectrum Disorder (ASD) symptom severity in a South African population
… and social impairments. ASD shows evidence of a genetic aetiology, with a large body of research linking ASD to polymorphisms in several different genes and gene families, including those involved in circadian rhythm generation and melatonin biosynthesis. Sleep disorders are highly comorbid with …
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The production and gene polymorphisms of tumor necrosis factor-alpha in patients with tuberculosis in the Vhembe District, Limpopo Province
… system. Although mutations in immune-related genes may directly impact a host’s ability to control the infection when exposed to M.tb, the pro-inflammatory cytokine Tumor Necrosis Factor- α is crucial in host defence against TB and granuloma formation. Therefore, this study aimed to assess the …
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Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
… factor for fracture, independent to BMD, and is genetically determined. However, genetic studies on bone geometry compared with BMD are scarce. Estrogen receptor a (ER-a) gene and its products have been shown to be of functional importance in bone metabolism. Although many studies have been …
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The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults
… of the insulin-like growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 …
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INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING
… OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII …
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Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma
… protein (IL-1RAcP). We investigated whether genetic polymorphisms of IL-1B and IL-1RAcP genes are associated with persistent HBV infection and the presence of hepatocellular carcinoma (HCC). Methods: We enrolled a total of 292 patients with chronic HBV infection (111 with chronic hepatitis, …
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Polimorfisme gen apolipoprotein E pada pasien infark miokard akut (IMA) di Rumah Sakit dr. Saiful Anwar Malang
… ini bertujuan untuk mengetahui variasi genetik (polimorfisme) gen Apo E pada pasien IMA di Rumah Sakit dr. Saiful Anwar Malang. Sample darah diambil dari 10 pasien IMA dipilih sesuai dengan kriteria inklusi dan eksklusi. Kemudian dilakukan isolasi DNA menggunakan Geneaid DNA Ekstraction …
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Prevalence of interleukin-1 polymorphisms and its association with periodontal disease status in the Xhosa population of South Africa
… experimental evidence indicates that there is a genetic influence of risk factors for periodontitis. A specific pattern of IL-1 polymorphisms (known as the composite IL-1 genotype) has been found to influence the severity of chronic periodontitis. The objective of this study was to evaluate the …
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Candidate Genes for Late Diabetic Complications
… result of chronically elevated blood glucose. Genetic factors are believed to play role in pathogenesis of diabetic complications. The aim of this study was to 1) To test the usefulness of the new WHO criteria for clinical staging of diabetes in the characterization of diabetic patients. 2) To …
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Taste physiological mechanisms and their health implications, analyzed by genetic, epigenetic, and artificial intelligence analyses
Taste perception is a complex trait influenced by genetic, epigenetic, physiological, and pathological factors, with significant implications for nutrition, health, and disease. Our studies integrated molecular biology, psychophysics, and advanced machine learning methods to explore …
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The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and …
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La percezione del gusto amaro nell’uomo: la sensibilità gustativa al 6-n-propiltiouracile (PROP) come marker della variabilità individuale con implicazioni fisiologico-nutrizionali
… It is associated with the bitter receptor gene (TAS2R38) and with differences in the salivary proteins involved in taste function. Among them, the enzyme Zn dependent gustin, a trophic factor of taste buds. We investigated the possible association of PROP taste phenotype with TAS2R38 …
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