Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"gene network analysis"”.
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Applications of next-generation sequencing technologies and advanced analytical methods to understand gene by environment interactions
… activity. Results offered insights into genetic factors behind activity dependence and provided a model for understanding addiction and other reward-dependent behaviors.Most genes differentially expressed betweenactivity genotypes were only moderately differentially expressed between …
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Mechanisms of defective insulin secretion in type 2 diabetes
… unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellular basis for impaired insulin secretion in T2D. We found that genetic variants for type 2 diabetes near TCF7L2 and ADRA2A were associated with reduced …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
… still controversial, many studies indicated that genetic factors play an important role in the ASD pathology. It has been shown that there is a remarkable genetic heterogeneity among ASD cases and thousands of genes may be associated with this disorder. The human brain can be separated into …
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Differential modeling for cancer microarray data
… changes in the expression levels of each single gene individually. In this work, we proposed novel computational approaches to identify the differential genes between two phenotypes. These approaches aim to quantitatively characterize the differences between two phenotypes and can provide better …
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Genetic parameters and genomic analysis of semen quality and fertility traits in pigs
… pig industry by assisting and disseminating the genetic progress. Currently, young boars are selected for AI based on their breeding values for production traits and selecting boars for semen traits, such as volume, concentration, motility and morphology, and for low variation in semen quality …
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Models of neurodegeneration using computational approaches
… disease (AD), as one of the most common neurodegenerative diseases, is characterized by the loss of neuronal dysfunction and death resulting in progressive cognitive impairment. The main histopathological hallmark of AD is the accumulation and deposition of misfolded Aβ peptide as amyloid …