Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"gene methylation"”.
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Variation in age at menarche and adult reproductive function: the role of energetic and psychosocial stressors
… subsistence environments, and 4) investigate gene methylation as a potential mechanism mediating the relationship between key stressors and reproductive function. I first investigated relationships between parent-adolescent communication and age at menarche in a diverse sample of 128 …
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Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells
… by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
… metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in metastasis to the brain is not well understood. To identify epigenetic drivers of brain metastasis, a combined candidate gene screen using literature review, bioinformatics analysis of 450K …
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The Relationship between methylation and genes associated with opioid response in humans.
… pain relief and / or intolerable side effects. Genetic polymorphisms in opioid pharmacodynamic and pharmacokinetic important genes have been investigated however there has been a lack of conclusive results. Epigenetic gene regulation is another study field of interest. DNA methylation is a gene …
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Folate: Friend or Foe? An investigation into the opposing roles of folate in glioma
… over the last 40 years due to the heterogeneity of tumours and the difficulty of specifically targeting the tumour whilst sparing surrounding healthy tissue. Altered gene methylation is often seen in glioma cells, but methylating agents such as folate, may reverse aberrant methylation. …
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Assessment of stress-induced and developmentally-induced DNA methylation changes in barley (Hordeum vulgare L.)
DNA methylation is involved in both plant development and adaptation to environmental stress. Changes in DNA methylation can affect the expression of genes that are important for both plant tissue differentiation and stress response. Characterisation of tissue and stress specific methylation …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… properties and cytotoxicity of AAQs and HAAQ congeners. All compounds were shown to be weak*to*moderately binding to DNA, and symmetrical 1,4-di-substituted compounds were shown to be non*toxic (IC50 = 100 :/! with non-symmetrical analogues generating IC50 values in the 1-100 :/ range. No …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… properties and cytotoxicity of AAQs and HAAQ congeners. All compounds were shown to be weak*to*moderately binding to DNA, and symmetrical 1,4-di-substituted compounds were shown to be non*toxic (IC50 = 100 :/! with non-symmetrical analogues generating IC50 values in the 1-100 :/ range. No …
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High fat diet causes hepatic lipid accumulation by programming lipid synthesizing genes via gene body methylation
… diet. However, it is still unclear what role epigenetic mechanisms play in hepatic lipid accumulation. We hypothesize that a HFD will cause greater hepatic lipid accumulation through increased lipid synthesizing gene expression via decreased gene methylation. The objective of this study is to …
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An investigation of the impact of the B cell lymphoma factor Activation Induced Cytidine Deaminase (AICDA/AID) on epigenetic plasticity
… for addressing therapeutic challenges. Epigenetic regulation has recently emerged as a prominent factor in cancer progression, and aberrant epigenetic alterations have been reported in many key cancer-driving genes. The overexpression of the DNA modifying enzyme Activation-induced cytidine …
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Investigating HK2 as a potential therapeutic target in glioblastoma
… are hindered predominantly by the complex genetic background of glioblastoma heterogeneity, as such there is a compelling need for the development of effective therapeutics. An approach is to target abnormal metabolic pathways that are universally dysregulated in glioblastoma. The …