Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"gene identification"”.
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Archaeal Gene Identification
… unique nor copious elements of the archaeal gene complement. In their stead were numerous proteins with no identified function and a significant literature describing biochemical reactions and phenotypes yet to be associated with genes. This thesis reports on several different projects, each …
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Gene identification in intellectual disability
Contains fulltext : 107980.pdf (Publisher’s version ) (Open Access)
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Computational methods for disease gene identification in intellectual disability
Contains fulltext : 207613.pdf (Publisher’s version ) (Open Access)
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Comparative gene identification in mammalian, fly, and fungal genomes
… step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that have been conserved by natural selection over millions of years of evolution. I develop …
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Gene identification using phylogenetic metrics with conditional random fields
… a comprehensive and accurate annotation of all genes encoded in the genome, providing the basis for understanding human variation, gene regulation, health and disease. Traditionally, the problem of computational gene prediction has been addressed using graphical probabilistic models of genomic …
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FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats
… aetiology involving both environmental and genetic factors. Large efforts have been directed towards the understanding of the molecular mechanisms underlying RA. Because of the complexity of the disease in humans, animal models for RA have become attractive tools for gene-identification. Use …
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Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome
… and hypoalbuminemia. It represents a heterogeneous group of glomerular disorders characterized by distinct causes and histopathologic lesions. The present thesis evaluates the contribution of genetics in conditions commonly associated with NS: the immune complex-mediated …
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The Mycobacterium tuberculosis KatG gene : identification of a novel function and analysis of the regulation of expression
… third of the Mycobacterium tuberculosis katG gene was previously shown to confer resistance to ethyl methane sulfonate on DNA repair-deficient Escherichia coli cells. The first aim of this study, therefore, was to examine the role played by the M tuberculosis katG gene in DNA repair. The …
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THE GENETIC BASIS OF INTERSPECIFIC FEMALE PREFERENCE IN DROSOPHILA SIMULANS
Behavioral differences between species have a genetic basis and contribute to species isolation. Genomic regions have been identified that influence female rejection of heterospecific males on the right arm of the third chromosome in Drosophila, however, no individual loci have been identified. …
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Conditional Multifactorial Contingency (CMC) Model and Its Applications
… numerous cutting-edge research studies: heterogeneities at the individual level with respect to more than one factor. Examples of such heterogeneities include but are not limited to: 1) unequal susceptibility of different patients, and 2) large diversity in gene length, GC content, etc., along …
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Accelerated Engineering of Optogenetic Tools with a High-throughput Microwell Array Platform
Optogenetics has shifted from a cutting-edge technology to a mainstay experimental technique. At its core, optogenetics is the use of light sensitive proteins to report or control biological activity. The unique spatiotemporal precision afforded by optogenetic tools has propelled the technique to …
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Molecular identification of silk proteins in the gumfooted lines and attachment discs of the black widow spider, latrodectus hesperus
… and identified. One of the first steps in gene identification relies on the identification of the proteins in the silk fibers.</p> <p>No previous study has demonstrated the molecular constituents of gumfooted lines. In the course of this research, the core fibroins in the gumfooted lines …
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Gene discovery in Catharanthus roseus using virus induced gene silencing
This thesis presents the use of Virus Induced Gene Silencing (VIGS) for the discovery of enzymes and transporters involved in monoterpene indole alkaloid (MIA) metabolism in the medicinal plant Catharanthus roseus. C. roseus is the source of a number of MIAs that are used as chemotherapeutic agents …
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Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle
… rate is a qualitative trait regulated by several genes and is strongly affected by the environment. With the development of biotechnology and gene identification, scientists are able to determine which genes affect these productivity traits to improve accurate selection decisions. Prolactin (PRL) …
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THE ROLE OF CGI-58/ABHD5 IN LIPID METABOLISM, INFLAMMATION, AND INSULIN ACTION
… In 2001, a novel protein known as Comparative Gene Identification 58 (CGI-58) was discovered to regulate cellular levels of triglyceride, a major lipid storage molecule. Humans with genetic mutations in CGI-58 accumulate triglyceride throughout their bodies and have a skin defect, fatty liver …
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Identifying modifier genes in SMA model mice
… 1 in 5000-10000 newborns, one of the leading genetic causes of infant death in USA. Mutations in the SMN1, UBA1, DYNC1H1 and VAPB genes cause spinal muscular atrophy. Extra copies of the SMN2 gene modify the severity of spinal muscular atrophy. Mutations in SMN1 (Motor Neuron 1) mainly causes …
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Characterization Of Antimicrobial-Resistant staphylococcus Spp. In Food Animals And Retail Meat
… antimicrobial susceptibility testing, resistance gene identification and conjugation. <i>Staphylococcus lentus</i>, <i>Staphylococcus sciuri</i>, <i>Staphylococcus xylosus</i> and <i>Staphylococcus haemolyticus</i> accounted for over 96% of the isolates. Resistance to macrolides, tetracyclines, …
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Metabolic engineering of C. glutamicum for amino acid production improvement
… design of more productive biological systems by genetically modifying metabolic pathways. In this thesis we report such an optimization in the bacterial strain Corynebacterium glutamicum that is employed for the fermentative production of various amino acids such as lysine. The main goal of the …
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Gene Discovery In Nonsyndromic Cleft Lip With Or Without Cleft Palate
… year in the United States, is caused by both genetic and environmental factors. Orofacial clefts affect the mouth and nose, causing severe deformity of the face, which require medical, dental and speech therapies. Despite having substantial genetic liability, less than 25% of the genetic …
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GENETIC DISSECTION OF PINE1 CONTROLLED STEM ELONGATION AND NEW INSIGHTS INTO LONG DAY FLOWERING IN ORYZA SATIVA
… involved in the GA signalling pathway, we have generated single and double knockout mutants with CRISPR-Cas9 of pine1 and four well-characterized genes belonging to GA biosynthesis, perception and signalling pathways: GIBBERELLIN INSENSITIVE DWARF1 (GID1), GIBBERELLIN INSENSITIVE DWARF2 (GID2), …
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