Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"gene expression profile"”.
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Microarray time-series data clustering via gene expression profile alignment
Clustering gene expression data given In terms of time-series is a challenging problem that imposes its own particular constraints, namely, exchanging two or more time points is not possible as it would deliver quite different results and would lead to erroneous biological conclusions. In this …
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Gene expression profile of ethanol-stressed yeast in the presence of acetaldehyde
… for improving ethanol tolerance in yeast. Gene array analysis was used to study gene expression in Saccharomyces cerevisiae during acclimatisation to non-lethal ethanol stress, in the presence and absence of acetaldehyde. Acetaldehyde caused significant changes in gene expression in …
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Statistical Analysis of Gene Expression Profile: Transcription Network Inference and Sample Classification
The copious information generated from transcriptomes gives us an opportunity to learn biological processes as integrated systems; however, due to numerous sources of variation, high dimensions of data structure, various levels of data quality, and different formats of the inputs, dissecting and …
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Adverse Childhood Experience-conditioned serum from young adults promotes a dysregulated endothelial cell gene expression profile
… The objective of this study was to investigate gene expression changes in primary endothelial cells when exposed to serum of those who have experienced ACEs (0 vs. ≥4). METHODS: Serum samples came from the Niagara Longitudinal Heart Study (NLHS). Samples collected from young male participants …
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Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses
… potential biomarkers and characterize their gene expression profile in order to tailor a therapeutic approach to HIV-1. Since these cells are exceedingly rare and cannot be distinguished from uninfected CD4+ T cells, ex vivo analysis on a single cell level has not been feasible. In the first …
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High resolution metabolic flux determination using stable isotopes and mass spectrometry
… to communicate changes from the environment to gene expression and vice versa. Genes are transcribed to proteins, which catalyze metabolic pathways, whose activity may in return affect gene expression. DNA microarrays allowed the measurement of the full gene expression profile under a particular …
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An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
… ADY and investigated the ensuing comprehensive gene expression profile in comparison to a non-neuronal cell line, again by utilizing the Affymetrix array chip. The conducted studies exerted a highly cell-specific transcriptional response with neuron-specific attributes in the swine neuronal cell …
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Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… with type I diabetes. Immune defects in the pathogenesis of diabetic embryopathy have been suggested. We hypothesized that activated immune system can counteract diabetic effect and result in prevention of diabetic embryopathy. Diabetes was induced in pregnant ICR mice by streptozocin injection. …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust cytokine burst is believed to give NKT cells the capacity to act as a link between innate and adaptive …
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The role of viral sequences in genetic aberrations and malignant transformation
… was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous …
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Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine
… The most promising result is the gene expression profile for “radioresistance” found in a patient cohort consisting of 100 lymph node negative patients operated with breast conservation surgery and either postoperative radiotherapy or not. The samples were analyzed with …
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LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
… long non-coding RNAs (lncRNAs), which influence gene expression and cardiac cell fate. This thesis focuses on verifying and characterizing of one key lncRNA, VENTHEART (VHRT), which was identified as one of the top upregulated markers in cardiomyocyte (CM) development. Utilizing human pluripotent …
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Some Clustering Approaches for High-dimensional Data
… research in recurrent event data and genomic expression data, with the goal of incorporating new features to extend existing methods and derive meaningful conclusions. In the first framework, we proposed a nested clustering model for recurrent event data to capture the heterogeneity structure …
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MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse
MicroRNAs mediate developmental regulation of gene expression via translational repression of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during early development. In this thesis, I have examined the role of a family of …
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Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
… symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a heterogeneous disease comprising different disease entities, which is of importance in clinical decision-making as well as in research. This thesis describes explorative approaches to …
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Characterization of human foreskin Langerhans cells
… centrifugation, sorted, quantified and immune-profiled by flow cytometry. CD1a and CD207 were used to identify Langerhans cells while HLA-DR, CD80, CD86 and CD40 were used as markers of maturity and activation. The gene expression profile of sorted LCs was also examined by single-cell …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… are characterized by aberrant myeloid marker expression. Additionally, ZNF384 rearrangements are the defining lesion in nearly half of pediatric B/myeloid mixed phenotype acute leukemia. These fusions juxtapose full-length ZNF384 to the N terminal portion of a diverse range of partners, most …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… regulation patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene …
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Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a novel oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation and tumorigenesis. However, the molecular mechanism …
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Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model
Understanding the impact of epigenetic mechanisms on tumorigenesis is essential, as epigenetic alterations are associated with tumor initiation and progression. Because epigenetic changes are reversible, they are potential targets for cancer therapy. Nucleosome Remodeling Factor (NURF) is a …
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