Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"gene expression control"”.
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Gene expression control and antimicrobial peptide production by haute couture bacteria
… synthetic systems have been built with novel gene expression dynamics. Additionally, cells have been engineered to efficiently produce high value compounds, including a number of recombinant protein molecules. Now, wonderful opportunities abound for improving the human condition with synthetic …
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Gene Expression Control for Synthetic Patterning of Bacterial Populations and Plants
… human minds for millenia. Empowered by modern genetic techniques, molecular biologists are now striving to not only dissect developmental processes, but to exploit their modularity for the design of custom living systems used in bioproduction, remediation, and regenerative medicine. Currently, …
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The Functional Role for Chromatin Loops in Gene Expression Control During Human Neuron Maturation
… question. Here, we summarize the field of epigenetics and chromatin in neuroscience, examine neural model systems, and build an auxin-inducible degron to deplete the architectural protein CTCF and disrupt loops genome-wide on short time scales during human induced pluripotent stem cell …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, beginning from the characterization of a mutual regulation between lncRNA MALAT1 and its natural antisense transcript TALAM1, followed by the identification and functional characterization of …
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Post-transcriptional control of gene expression
Gene expression describes the process of making functional gene products (e.g. proteins or special RNAs) from instructions encoded in the genetic information (e.g. DNA). This process is heavily regulated, allowing cells to produce the appropriate gene products necessary for cell survival, adapting …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory …
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Engineering control of eukaryotic translation with application to the malaria parasite Plasmodium falciparum
Experimenter control of target gene expression is a fundamental component of molecular biology research. In many systems, tools exist that allow generalizable control of gene expression at the transcriptional or post-transcriptional level. Plasmodium falciparum, the protozoan parasite responsible …
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Autonomous Finite Capacity Scheduling using Biological Control Principles
… over the past several years has focused on the generation of precise and almost exact measures for the working schedule presupposing complete information and a deterministic environment. During execution, however, production may be the subject of considerable variability, which may lead to …
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Transcription regulation in Plasmodium falciparum : functional characterisation of general transcription factor IIB
… tightly synchronised changes in stage-specific gene expression. In eukaryotes, regulation of RNA Polymerase II transcription initiation is one of the main mechanism of gene expression control. Past research has revealed the presence of crucial elements of RNA Polymerase II (RNAPII) transcription …
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Investigation of transcription factor binding at distal regulatory elements
… and function necessitate precise patterns of gene expression. Control of gene expression is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of transcription …
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DNA catalysts for amide bond cleavage and for lysine side chain modification
… the practical challenges associated with protein expression and purification. DNA offers further advantages over RNA: DNA is cheaper, more stable, and easier to synthesize. If DNA can act as an efficient catalyst, the area of deoxyribozyme research is relatively unexplored, making the chances of …