Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"gene expression alterations"”.
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
… widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine gene expression changes in different DCIS models (MCF10.DCIS, SUM102 and SUM225) in comparison to …
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CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS
… is known regarding the effects of cholesterol on gene expression. The present study was therefore carried out using microarray-based approaches to elucidate the effects of cholesterol on gene expression changes in the brain and cerebral vessels, which may contribute to these disorders. Present …
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Análises de redes modulares de co-expressão gênica revelam vias importantes na doença de Alzheimer e paralisia supranuclear progressiva
The incidence of neurodegenerative diseases leading to impairment of cognitive functions and dementia have increased in recent years, mainly because of enhanced longevity in the population worldwide. Understanding the onset and progression of these pathologies can help to develop preventive and …
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Applying multi-omics to detect indolent and aggressive early-stage lung adenocarcinoma
… spatial transcriptomics. Interestingly, gene expression alterations associated with VI were detectable beyond the invaded vessels, shedding light on changes in the broader tumor microenvironment associated with VI. Moreover, we developed a transcriptomic predictor of VI that was not …
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Identification of estrogen-regulated genes in the cerebral cortex and development of a novel method to detect methylated DNA
… cerebral cortex. However, the transcriptional alterations underlying E2-mediated protection in this brain region are largely unknown. To understand the role of E2 in the cerebral cortex, we examined the cerebral cortical transcriptome using a mouse model system. Adult female mice were …
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Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
… H3 on lysine 27 (H3K27me3), a repressive epigenetic mark. Consequently, PRC2 dysfunction may induce significant epigenomic and gene expression alterations. Our research aimed to understand mechanisms underlying benign-to-malignant tumor transformation for improved diagnosis and treatment of …
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Bronchial gene expression associated with airway pre-malignancy and lung cancer subtypes
… due to the lack of early detection. Meanwhile, gene expression profiling can identify molecular responses to carcinogen exposure and tumorigenesis. We have previously identified lung cancer-associated gene expression alterations in the normal bronchial airway epithelium of ever smokers with and …
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Leveraging genomic and molecular variations to understand the regulatory landscape in human cancers and differentiating stem cells
Genetic and molecular variations are closely intertwined; while genetic factors drive phenotypic differences ranging from gene expression to organismal traits, phenotypic variations are the target of evolutionary selection, what eventually results in genetic changes. As technological advances have …
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Astrocyte and vascular changes contribute to Alzheimer's disease
… (AD), the most prevalent age-related neurodegenerative disorder, is defined by the pathological accumulation of amyloid-β (Aβ) peptides, neurofibrillary tangles (NFTs), neuronal loss, and the activation of astrocytes and microglia. One of the early indicators of AD is a global reduction in …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… compounds may lead to comparable histologic and gene expression alterations in the fetal mouse thymus and liver. Treatment of pregnant C57Bl/6 mice with doses of 5 or 10 ug/kg TCDD or 48 ug/kg DES by oral gavage on gestation days (gd) 14 and 16 severely depressed day 18 thymic cellularity. …
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Genome wide expression analysis and metabolic mechanisms predicting body weight maintenance
… impact of weight reduction on adipose tissue gene expression was observed. Gene expression alterations over weight reduction included several cellular metabolic genes involved in lipid and glucose metabolism as well as insulin signalling and regulatory pathways. These changes were also …
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Analysis of Plant Homeodomain Proteins and the Inhibitor of Growth Family Proteins in Arabidopsis thaliana
… Many times, these final responses require new gene expression events that have been stimulated or repressed within the nucleus. Thus, much of the understanding of signal transduction pathways converges on the understanding of how signaling affects gene expression alterations (Kumar et al., …
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Investigating the origins of polyploidy in Barretts oesophagus and oesophageal adenocarcinoma
… lines indicated numerous copy number changes and gene expression alterations of important inner and outer kinetochore components including genes within the CCAN and KMN networks. These findings were confirmed by the analysis and comparison of the expression and localisation of KMN proteins in OEAC …
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Decoding the interplay between the microbiota-gut-brain axis and the hypothalamic regulation of eating behaviour
… a prebiotic or putative probiotic, restored the alterations induced by the exposure to this unhealthy diet during early-life in an intervention- and sex- dependent manner (Chapter 2). This highlights the promising potential of microbiota-targeted strategies to ameliorate these metabolic effects, …
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Investigating HK2 as a potential therapeutic target in glioblastoma
… are hindered predominantly by the complex genetic background of glioblastoma heterogeneity, as such there is a compelling need for the development of effective therapeutics. An approach is to target abnormal metabolic pathways that are universally dysregulated in glioblastoma. The …
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Food processing modulation on breast cancer
… and negative controls received sham pellets. GeneChip Human Genome U133 Plus 2.0 Array platform was used to evaluate gene expression, and results were analyzed using bioinformatics approaches. Tumors in MS-fed mice exhibited higher expression of tumor growth suppressing genes ATP2A3 and BLNK, …