Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5089 for “"gene expression"”.
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Light-activated gene expression
A method for activating gene expression in cells by using photo-caged small molecules was developed. This method uses the Nuclear Hormone Receptor (NHR) family as a model system. This tool provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules …
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TrkB and gene expression
… in understanding how neurotrophins regulate gene expression and, in particular, how BDNF does this through its high affinity receptor TrkB during neurogenesis. In order to answer this question, I planned to adopt the following approaches. First, to analyze global changes in gene expression …
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Gene expression array simulator
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 2002.
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Gene expression in healing tendon
… While common, the underlying molecular and genetic processes of tendon damage and repair remain poorly understood. The work described herein used genome-wide expression analyses to investigate tendon injury and healing from three perspectives. The first identified novel gene expression in …
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Control of uteroglobin gene expression
Eukaryotic nuclear genes are regulated by a complex array of transcription factors that influence RNA polymerase II activity. Included among these factors are the cellular receptors for steroid hormones. The rabbit uteroglobin gene expression is positively stimulated by progesterone, and binding …
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Gene Expression in the Choanoderm
… <em>Ephydatia muelleri</em>, we have performed gene expression analysis of the choanoderm tissue and have begun to develop an experimental method to validate and characterize the function of candidate choanoderm genes. The data suggest that the choanoderm may be the only metazoan tissue not …
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Gene expression analysis in breast cancer
… in breast cancer. An in-house breast cancer gene expression dataset comprising 17 normal and 104 tumour samples was analysed to identify important genes and pathways relevant to various clinical parameters. Our results identified groups of patients with similar expression profiles, the …
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Computational analysis of gene expression data
Gene expression is central to the function of living cells. While advances in sequencing and expression measurement technology over the past decade has greatly facilitated the further understanding of the genome and its functions, the characterisation of functional groups of genes remains one of …
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Controlling Gene Expression with Synthetic Molecules
Aberrant gene expression patterns have been implicated in several pathological states. Synthetic molecules capable of functionally mimicking native transcription factors and regulating gene expression in a specific and predictable manner may represent a new paradigm in drug development. Native …
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Inference from binary gene expression data
… measuring the mRNA abundances of thousands of genes in a single experiment. Analysing such large dimensional data is a challenge which attracts researchers from many different fields and machine learning is one of them. However, the biological properties of mRNA such as its low stability, …
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Post-transcriptional control of gene expression
Gene expression describes the process of making functional gene products (e.g. proteins or special RNAs) from instructions encoded in the genetic information (e.g. DNA). This process is heavily regulated, allowing cells to produce the appropriate gene products necessary for cell survival, adapting …
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Switching in bacterial gene expression networks
… fit for the environmental change. The underlying genetic circuitry plays a key role in eliciting multiple phenotypes by an isogenic population of bacteria. Understanding the underlying mechanism requires careful and systematic approach. In this study, we investigated two very well-known systems: …
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Collagen gene expression in human cancer
… adjacent normal tissue for analysis of collagen gene expression by Northern blot hybridisation. Stage I breast tumours had increased α1(I) and α2(I) collagen mRNA, whereas stages II and III tumours had decreased mRNA levels when compared to the adjacent normal tissue. This stage-specific change …
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Gene expression studies using retroviral vectors
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1986
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RET Mediated Gene Expression and Cell-Migration
… sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex formation between a member of the Glial cell line-Derived Neurotrophic Factor family of ligands and a member of the GDNF-Family Receptor α co-receptors. Upon complex formation, RET becomes phosphorylated …
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INFERRING TUMOR PROPERTIES FROM GENE EXPRESSION DATA
… diagnostic and prognostic clinical applications. Gene expression is used to predict the tissue of origin (TOO) of tumor samples, which is relevant in several scenarios such as the diagnosis of cancer of unknown primary (CUP), early cancer detection by means of circulating tumor cells (CTCs) or …
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