Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"gene enrichment"”.
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… patients with high SOX2 mRNA expression have gene enrichment in cell cycle and DNA damage repair pathways. One protein that regulates cell cycle progression and transcribes DNA damage repair proteins is E2F1. This thesis found that E2F family gene targets are upregulated in response to …
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Identification of new functional resistance genes against <i>P. infestans </i>in <i>Solanaceae</i> species
… B3C1HP. Using bulked-segregant resistance gene enrichment and sequencing (RenSeq) analysis in this population, which segregated 1:1 for the phenotype, the resistance was mapped to the lower end of chromosome 9. Furthermore, I developed a novel diagnostic tool, dRenSeq, to screen existing …
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Characterization of Microrna Expression Profiles and Role of Nodal-Related Genes in Zebrafish Ovarian Follicles
… IIIa and IIIb follicular cells. In addition, gene enrichment and pathway analyses of the predicted targets of the significantly regulated miRNAs supported the involvement of several key signaling pathways in regulating ovarian function. We then investigated the role of Nodal, a member of the …
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The genetic interactions of PKHD1 and ATMIN in autosomal recessive polycystic kidney disease (ARPKD)
The main gene associated with Autosomal Recessive Polycystic Kidney Disease (ARPKD) is PKHD1 which encodes a ciliary protein associated with planar cell polarity. In mice, mutations in the transcription factor Atmin can present with an ARPKD-like phenotype with kidney disease similar to an early …
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Bioinformatics analysis of liver and adipose tissue microarray data from periparturient dairy cattle and development of a web-based ruminant specific microarray database
… reductionist approach discussing the individual genes, proteins or pathways. This approach does not necessarily evaluate the overall biological effect of a particular condition (e.g. treatment, physiological state) on a pathway. In some instances these tissues have been investigated at the …
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Investigations into the Functional Significance and Plasticity of O-linked Glycosylation
… phenotype. RNA-sequencing revealed EMT-related genes, relating to mesenchymal markers and EMT signalling pathways, were differentially expressed in O-GalNAc glycan-negative and TGF-β1 treated cell populations compared to their O-GalNAc glycan-positive counterpart. Differentially expressed gene …
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Unsupervised Signal Deconvolution for Multiscale Characterization of Tissue Heterogeneity
… and subpopulation proportions. Tissue heterogeneity, arising from multiple cell types, is a major confounding factor in studying individual subpopulations and repopulation dynamics. Tissue heterogeneity cannot be resolved directly by most global molecular and genomic profiling methods. While …
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De novo Sequencing and Analysis of <em>Salvia hispanica</em> Transcriptome and Identification of Genes Involved in the Biosynthesis of Secondary Metabolites
… and its growing public demand, very limited gene sequence information is currently available in public databases. In this project, we generated 90 million high quality 150 bp paired-end sequences from the chia leaf and root tissues. The sequences were de novo assembled into 103,367 contigs …
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An investigation of gene expression, alternative splicing and nonsense-mediated decay in potato in response to Phytophthora infestans infection
… immunity (ETI). Using a NB-LRR gene enrichment and RNA-seq, previous studies identified over 700 NB-LRR genes in potato.<br/><br/>Dynamic changes in alternative splicing (AS) of NB-LRR genes have been shown in tobacco and Arabidopsis to be essential for the plant response to …