Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"gene duplication"”.
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Gene duplication and the evolution of the higher diptera
<p>Gene duplication is an important source of evolutionary innovation. Using the publicly available genomic information, I studied lineage-specific gene duplications in <i>Drosophila melanogaster</i> (fruit fly), <i>Anopheles gambiae</i> (mosquito), <i>Tribolium castaneum</i> (red flour beetle), …
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Computational Tools for Metabolic Modeling and Gene Duplication Analysis
… prior knowledge of functional links between genes to improve the performance of the algorithm. The results obtained by AccliNet are compared with the performance of existing algorithms and are shown to be an improvement in this area. Next, we delve deeper into the metabolic response of the …
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Investigating the role of gene duplication in the evolution and divergence of Arachnids
Gene duplication underlies the origin of novel genes with potential new functions that can contribute to organismal divergence. Relaxed selection on duplicates allows for the accumulation of mutations in coding and/or regulatory sequences of duplicated genes leading to subfunctionalization and/or …
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Evolution Via Gene Duplication and Alternative Splicing In The Eukaryotic Ski7 and Hbs1 Genes
<p>Gene duplication and alternative splicing are both recognized as important drivers of proteomic diversity and innovation during evolution, but the evolutionary changes over long periods of time or the interrelations of the two processes has not been extensively studied. Here I study these …
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Phylogeny Inference in the Presence of Incomplete Lineage Sorting, Gene Duplication and Loss and Hybridization
… their most recent common ancestral species. A gene tree captures the evolutionary history of an individual gene or, more generally, non-recombining genomic region. A very complex relationship exists between the phylogeny of a set of species and the trees of genes in the genomes of those …
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EPSPS gene duplication in Palmer amaranth: relative fitness, inheritance, and duplication mechanism of the glyphosate resistance trait
… areas, the resistance is conferred through a gene amplification mechanism in which the target gene of glyphosate, 5-enolpyruvylshikimate-3-phosphate (EPSPS) is duplicated in the genome 100+ times, resulting in an overproduction of the EPSPS protein. With so much EPSPS enzyme available in each …
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Gene duplication and alternative splicing play a role in modulating the functions of the ZNF286A transcription factor
Neurogenesis, and the processes through which neural stem cells and progenitor cells differentiate into neurons, occurs most actively during embryonic development, although neural differentiation continues at lower levels in certain brain regions well into adulthood. A vast regulatory network …
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Phylogenetic Analysis of Human Cytomegalovirus pUS27 and pUS28: Ascertaining an Independent or Linked Evolutionary History
… products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis was used to investigate the origins of the US27 and US28 genes, which are …
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The plastid caseinolytic protease complex as a model for cytonuclear coevolution
… Protein complexes are frequently shaped via gene duplication. Many protein complexes contain paralogous proteins at their cores; the duplication of a self-binding protein leads to dimerization of the paralogous proteins and subsequent recruitment of additional subunits. Gene duplication after …
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Environmentally Influenced Duplication Patterns Followed by Functional Shifts Fueling the Evolution of Metazoan Sensory Systems
… environment have been extensively studied. How gene duplications have played an important role in sensory evolution by duplication followed by functional shifts resulting in neofunctionalisation has been analysed. This extensive neofunctionalisation allows for an expansion in the number of …
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Alternative Splicing Expands Spatiotemporal Expression Complexity of Arthropod N -Cadherin
Metazoan development requires mechanisms to generate cells with diverse functions. Cellular diversity is dictated by complex patterns of molecular expression, originating from dynamic spatiotemporal regulation of transcriptomes. Both gene duplication and alternative splicing have been proposed as a …
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Mechanisms of change in protein architecture
… of my thesis, I traced the history of animal gene families and the proteins these genes encode. By this means, I was able to infer events where changes in protein domain architectures took place. This showed that both insertions and deletions of single copy domains preferentially occur at …
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Modelling evolution of genome size in prokaryotes in response to changes in their abiotic environment
… the classic Hutchinson niche space model, a gene was defined as a Gaussian function over a corresponding niche dimension. The cell can have more than one gene along a given dimension, and the envelope of all the corresponding responses is considered a full description of a cell’s phenotype …
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Molecular Evolution of Visual System Genes in Fishes
… a collection of evolutionary studies on two gene families, opsins and crystallins. Opsin proteins determine the wavelengths of light detected by the retina, while crystallin proteins contribute to lens transparency and refractory power. My studies focus on teleost fishes, because teleost …
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Evolution and statistics of biological regulatory networks
… thesis, I study the process of evolution of the gene regulatory network in Escherichia coli. First, I characterize the portion of the network that has been documented, and then I simulate growth of the network. In this study, I assume that the network evolves by gene duplication and divergence. …
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SELECTIVE FORCES SHAPING DUPLICATE GENE EVOLUTION: INSIGHTS FROM STOCHASTIC MODELING AND PATTERNS OF RETENTION
… changed and adapted to their environments. Gene duplication is an important mechanism for molecular evolution because it provides opportunity for functional novelty and molecular innovation. Gene duplication creates new functional gene copies with different selective pressures that allow …
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Evolutionary and Paleobiochemical Analyses of Heme Peroxidases
… (TPO).These comprise a functionally diverse multigene family of enzymes associated with such diseases as asthma, Alzheimer’s disease and inflammatory vascular disease. This study has determined how the enzymes in the multigene family of MHP are related. The order of gene duplication events has …
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Evolution and Genetics of Floral Color Polymorphisms in Clarkia gracilis ssp. sonomensis and Erythronium umbilicatum
… are pervasive in nature. Understanding the genetic basis of such polymorphisms allows us to address major evolutionary questions including: what types of genetic changes contribute to the evolution of phenotypic diversification? Have they arisen from new or pre-existing genetic material? And …
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Immunological Crosstalk between Human Transforming Growth Factor-β1 and the Malaria Vector Anopheles stephensi
… to the mammalian host. One candidate effector gene is Anopheles stephensi nitric oxide synthase (AsNOS), whose inducible expression and subsequent synthesis of nitric oxide (NO) limits Plasmodium development in A. stephensi. In mammals, one of the most potent physiological regulators of NOS …
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Genetic duplication in Salmonella typhimurium
A gene duplication occurs in Salmonella typhimurium which involves about 30% of the genome. The frequency of formation and loss of this duplication was determined in a Rec.A⁻ strain and a PolA⁻ strain and compared to that of a RecA⁺, PolA⁺ strain. The frequency of formation was found to be reduced …
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