Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"gene copy number"”.
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Delineation of the molecular mechanisms underlying DNA replication initiation and changes in gene copy number during Drosophila development
… in Drosophila polyploid tissues. We identified copy number changes genome-wide in two additional polyploid tissues and compared our results to three previously profiled larval tissues. These results revealed a high level of tissue-specificity in the number of underreplicated sites within a given …
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Examination of gene deletion as a mechanism of RBM5 downregulation in tobacco smoke-associated lung cancer
RBM5 is a tumour suppressor gene with substantially decreased expression in most lung cancers, especially in smokers, that may result from gene deletion. The objective of this study was to determine if significantly decreased levels of RBM5 expression in the lung cancers of smokers was related to …
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An automated multicolour fluorescence in situ hybridization workstation for the identification of clonally related cells
… the identification of subpopulations (clones) of genetically similar cells within tissue samples through measurement of loci-specific Fluorescence in-situ hybridization (FISH) spot signals for each nucleus and analyzing cell spatial distributions by way of Voronoi tessellation and Delaunay …
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Quantifying Dyrk1a During Perinatal Development in the Hippocampus, Cerebral Cortex and Cerebellum of the Ts65Dn
The relationship between gene copy number and protein expression levels has not thoroughly been examined in humans or mouse models of Down syndrome (DS) in relationship to developmental changes in the trisomic brain. Found on human chromosome 21 (Hsa21) and triplicated in DS, Dual-specificity …
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
… plasmid-encoded. High-level expression of these genes results in resistance to almost all classes of BETA-lactam antibiotics. The mechanisms of high-level expression for the chromosomal AmpC genes from several organisms have been elucidated, whereas prior to data published from the work presented …
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Investigating the heritability of resistance fueling copy number variation in glyphosate resistant Amaranthus palmeri
Gene copy number variation (CNV) can arise as a response to selection pressure from the environment. Herbicide is one selective agent targeting and promoting the evolution of resistance in agricultural weed populations. In Amaranthus palmeri, CNV of the EPSPS gene, the target of glyphosate …
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DECIPHERING AND EXPLOITING ANEUPLOIDY IN CANCER
… genome instability and associated gene copy-number changes caused by aneuploidy to withstand selective pressures, such as chemotherapy. The development of resistance to chemotherapeutic drugs appears to be influenced by the emergence of recurrent karyotypes, suggesting that gene …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… to know whether: A) decreased mitochondrial biogenesis precedes brain plaque formation, neuronal death and memory deficits B) autophagosomal formation is overactive and/or degradation of autophagosomes is inhibited in AD and C) deficits in mitochondrial biogenesis and autophagy occur earlier in …
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A novel compound heterozygous NEB mutationin Korean patients with intellectual disability, epilepsy,and acongenital myopathy
… by intellectualdisability,epilepsy,and generalized muscle weakness of early childhood onset. I performed several conventional genetic tests to detect chromosomal aberrations, gene copy number variations, and candidate gene and mitochondrial gene mutations. After finding no abnormality ,I …
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Elucidation of the Molecular Mechanisms That Contribute to Variation in Susceptibility Testing Show the Need for Alternative Detection Methods of KPC-producing Gram-negative Bacteria
… The rapid spread of blaKPC into multiple genera of Gram-negative bacteria, the lack of effective treatment regimens, and the difficulty of identifying these pathogens using current detection methods in the clinical laboratories are the biggest challenges the KPC-producing organisms pose. …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… role played by mutators, and to identify gene deletions and amplifications that arise and persist in chronic infections we undertook DNA microarray-based comparative genome hybridization and CLONDIAG miniarray analyses on 21 clinical P. aeruginosa samples isolated from 5 CF patients. We …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… role played by mutators, and to identify gene deletions and amplifications that arise and persist in chronic infections we undertook DNA microarray-based comparative genome hybridization and CLONDIAG miniarray analyses on 21 clinical P. aeruginosa samples isolated from 5 CF patients. We …
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Molekulare Genomanalysen des invasiven Mammakarzinoms und Untersuchung des Einflusses chromosomaler Imbalancen auf die Genexpression
… was used to make detailed resolutions of cytogenetic aberrations in invasive breast cancer. The most frequent changes found were gains of 1q, 8q, chromosome 20, and losses involving 16q, 19p, 17p and chromosome 22. The chromosomal imbalances correlated neither with extent of tumour growth, …
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Integrative network modeling of large multidimensional cancer datasets
… sets, we introduce new modeling techniques and generalise existing methods for large-scale integration of cancer data. These methods aim to construct network models that link genetic, epigenetic, transcriptional and phenotypic events, by combining genome-wide measurements of multiple kinds. In …
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Characterizing resistance of Erysiphe necator to fungicides belonging to the quinone outside inhibitors and demethylation inhibitors
… isolates and among genotype groups are due to gene copy number variation. DMI resistance was found to decline after years of subculturing, and the decline appeared to occur after a few culture transfers of field samples on fungicide-free host leaves. The observed decline, together with the …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
… kb genomic DNA region containing the MYCN oncogene. While MYCN has been extensively investigated, it is unknown whether other genomic elements within the 130 kb amplicon play a role in neuroblastoma. In this study, I experimentally validated the novel long noncoding RNA up-stream of MYCN …
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Mechanisms Involved in the Expression of the AmpC Beta-lactamase Gene blaCMY-2 in Escherichia coli
… AmpC β-lactamases can be resistant to third generation cephalosporins and β-lactam/β-lactamase inhibitor combinations. Infections by these bacteria are associated with increased patient morbidity and mortality. Little is known about how plasmid-encoded AmpC genes are regulated or expressed. …
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Effect of soil amendments on the chemical transformation of arsenic and the microbial diversity in rice paddy microbiome
… the arsenic detoxification process. Also, arsM genes in composting manure could enhance arsenic methylation. Furthermore, cattle manure also enhances arsenic mobilization and increased arsenic assimilation in rice grain in some regions. However, the application of biomass ash, a source of …
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DYRK1A-Related Trabecular Defects in Male Ts65Dn Mice Emerge During a Critical Developmental Window
Down syndrome (DS) is a complex genetic disorder caused by the triplication of human chromosome 21 (Hsa21). The presence of an extra copy of an entire chromosome greatly disrupts the copy number and expression of over 350 protein coding genes. This gene dosage imbalance has far-reaching effects on …
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EPSPS gene duplication in Palmer amaranth: relative fitness, inheritance, and duplication mechanism of the glyphosate resistance trait
… areas, the resistance is conferred through a gene amplification mechanism in which the target gene of glyphosate, 5-enolpyruvylshikimate-3-phosphate (EPSPS) is duplicated in the genome 100+ times, resulting in an overproduction of the EPSPS protein. With so much EPSPS enzyme available in each …
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