Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 170 for “"gene cluster"”.
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Approximate common intervals based gene cluster models
… verschiedener Spezies bezüglich der enthaltenen Gene und deren Anordnung auf den Chromosomen verglichen werden. Ziel solcher Studien ist es, die Funktionen von einzelnen Genen und Genverbünden aufzudecken und ein besseres Verständnis für die auf Genomebene wirkenden evolutionären Prozesse zu …
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Efficient algorithms for gene cluster detection in prokaryotic genomes
… which means that the positions of their genes and parts of their regulatory or metabolic pathways are known. A new task in the field of bioinformatics now is to gain gene or protein information from the comparison of genomes on a higher level. In the approach of "comparative genomics" …
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Characterisation of the lipooligosaccharide biosynthesis gene cluster in campylobacter species
The extensive genetic variation in the lipooligosaccharide (LOS) core biosynthesis gene cluster, a majority of which occurs in the LOS outer core biosynthesis gene content present between lgtF and waaV, have led to the development of a classification system; with 8 classes (I-VIII) for …
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Identification and characterization of the inlGHE gene cluster of Listeria monocytogenes
In the present study, a new gene cluster of Listeria monocytogenes EGD containing three internalin genes was identified and characterized. These genes, termed inlG, inlH and inlE, encode proteins of 490, 548 and 499 amino acids, respectively, which belong to the class of large, surface-bound …
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Analysis of a Cotton Gene Cluster for the Antifungal Protein Osmotin
… of cotton DNA were found to encompass a cluster of two presumptive osmotin genes (OSMI and OSMII) and two osmotin pseudogenes (OSMIII and OSMIV). A segment of 16,007 basepairs of genomic DNA was sequenced from the overlapping genomic clones (GenBank Accessions AY303690 and AF304007). The …
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Normal Mixture Models for Gene Cluster Identification in Two Dimensional Microarray Data
… the data in preliminary steps and proposes a cluster analysis method which improves the interpretability of the cluster results. Cluster analysis of microarray data allows samples with similar gene expression values to be discovered and may serve as a useful diagnostic tool. Since microarray …
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DNA Methylation Landscape of the Fibrinogen Gene Cluster in the Equine Embryo
… DNA methylation across the fibrinogen gene cluster for equine liver, day 14 embryos, and endometrium. The methylation landscape of equine embryos is distinct from both liver and endometrium. However, in key regulatory regions the embryo and liver profiles were the same. The similarity …
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Molecular Analysis of the Essential Fatty Acid Biosynthetic Gene Cluster of Escherichia Coli
The genes encoding ACP and several key fatty acid biosynthetic enzymes are clustered at min 24 of the E. coli chromosome in the order of plsX, fabH, fabD, fabG, acpP, and fabF. I demonstrated that this cluster of genes was transcribed as a non-conventional operon. Multiple promoters were present …
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Regulation and characterization of the nitrogen assimilatory gene cluster in Clostridium acetobutylicum P262
… pathways. The long-term goal is the potential genetic modification of nitrogen utilization and/or electron distribution in the cell, to manipulate fermentation patterns for improved growth rate and solvent yields. The main aims of this research project were to: extend the sequence analysis of …
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Investigation of the antibacterial activity and the biosynthesis gene cluster of the peptide antibiotic feglymycin
… das zu einem hohen Anteil aus den nicht-proteinogenen Aminosäuren Hpg (4-Hydroxyphenylglycine) und Dpg (3,5-Dihydroxyphenylglycine) besteht. Zudem besitzt es eine interessante, alternierende Abfolge von D- und L- Aminosäuren und strukturelle Ähnlichkeiten mit den Glycopeptiden der …
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Structure, Regulation and Comparative Biochemistry of the Pyrimidine Biosynthetic Gene Cluster in Bacillus Subtilis (Atcase)
… Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster was cloned in Escherichia coli. The cloned fragment also complemented E. coli pyrB, C, D, E, and F mutants. A restriction map of the cluster was generated, and many subclones were analyzed for their ability to complement E. coli pyr …
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Comparative analysis of the promoters of the CyI-CyIIa-CyIIb actin gene cluster in the sea urchin Strongylocentrotus purpuratus
Three of the eight actin genes in the sea urchin Strongylocentrotus purpuratus were used for a comparative analysis. The cytoplasmic actin genes CyI, CyIIb and CyIIa are linked in the genome and encode very similar proteins. However, their spatial and temporal expression patterns are differentially …
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Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations
… the prevalence of <em>APOA1/C3/A4/A5</em> gene cluster, the interaction between these genes and flavonoids intake on how they impact cardiovascular disease (CVD) risks among U.S. adults. We focused on four aims: (1) to estimate the dietary flavonoids intake among U.S. adults; (2) to …
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Studies on expression, organization, and regulation of the gene cluster associated with the biosynthesis of Escherichia coli K99 adhesin
The biogenesis of the pilus adhesin K99 is dependent upon the expression of eight contiguous genes: fanA-H. These genes are encoded on an 87.8 kb plasmid. To study gene expression, regulation, and transcriptional organization of the gene cluster associated with K99, transposon mutagenesis using …
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Studies on carbohydrate metabolism in Bifidobacterium : isolation, characterisation and regulation of a sucrose-utilisation gene cluster in Bifidobacterium lactis
The primary aim of the project was, therefore, to analyse carbohydrate metabolism for the identification of and/or the development of prebiotic substrates, and to provide a molecular characterisation for their utilisation. Several carbohydrates were tested for their ability to support the growth of …
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Exploring the boundaries of shallow phylogeny in the YESS group and the dynamics of gene cluster and operon formation in bacterial genomes
… possible to separate such genomes into different genera, species and strains. Specifically, I addressed how different approaches such as the use of 16S rRNA phylogenetic trees, phylogenetic supertrees and concatenation of individual genes in order to construct phylogenetic trees compare with one …
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