Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"gelsolin"”.
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A NOVEL PRO-OXIDANT ROLE OF GELSOLIN IN CANCER CELL INVASION
Although gelsolin is often implicated in cancer cell invasion, the mechanisms remain poorly understood. We have identified a new role of gelsolin in creating a pro-oxidant milieu thereby enhancing cancer cell invasion. Increased gelsolin expression in HCT116 results in heightened ROS levels, …
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The Development and Implementation of a TMT-SRM Assay for the Validation of Candidate Biomarkers of Alzheimer’s Disease
… complement C3, alpha-2- macroglobulin, gelsolin, fibrinogen gamma-chain, serum amyloid p-component and complement factor H. These proteins were previously found to be differentially expressed between plasma of Alzheimer’s disease subjects and non-demented controls. Additionally, …
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Divalent Cation- and Cholesterol-Induced Perturbation in Pip2 Lateral Organization in Model Membranes - Cluster formation, Phase Partitioning, and PiP2-Protein interactions
… the effects of PIP2 on the target proteins gelsolin and DrrA. Comparison between experimental and numerical phase diagrams suggests that a simplified electrostatic model can predict Ca2+-driven formation of PIP2 clusters, but cannot account for the difference between Ca2+ and Mg2+ in …
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Simulated impact trauma and osteoarthritis: the role of cell volume and mechanotransduction
… for actin treadmilling cofilin, profilin and gelsolin mRNA was compared to untreated chondrocytes. REV5901 was observed to reduce cofilin (known actin depolymerizing factor) with 30 % (p<0.05) and increase profilin significantly by 75 % (p<0.001) respectively. Western blot analysis showed that …
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Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis
… in SLE patients compared to controls. Gelsolin was significantly downregulated in patients with RHD and in SLE patients with a flare-up and in remission. Given that data remain scant, further research into these proteins, along with others not previously identified, is warranted to …
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The role of PADs in the biogenesis of prostate cancer microvesicles which play a dysfunctional role on DC biology and the therapeutic potential of skeletal muscle microvesicles on prostate cancer cells
… analysis of the MVs revealed a candidate protein gelsolin that has been reported to exhibit anti-tumourigenic properties.
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Mechanical properties of F-actin network
… such as filamin and a -actinin, with and without gelsolin to control filament length. Microstructures of those networks were also characterized in terms of filament length, mesh size, and degree of bundling.
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Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… arrangements (intermediate filaments and a gelsolin-like adseverin). The most parsimonious explanation for these changes in protein expression assumes that C. gigas reduces nitrate to nitrite and nitric oxide, which reacts with superoxide anions to form the very reactive peroxynitrite. We …
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Calcium/Calmodulin Dependent Protein Kinase Type-II Associates with Flightless-I to Influence its Nuclear Localization
… proteins were identified, including the gelsolin related actin binding protein, Flightless-I. Fli-I is an actin binding and capping protein that also functions as a transcriptional coactivator. The CaMK-II-Fli-I interaction was confirmed with endogenous (un-tagged) proteins. The …
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INTEGRATIVE MODELLING FOR THE CHARACTERISATION OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULES
… the closed state conformations of the human gelsolin, a plasma protein. The second manuscript investigates the inactivation mechanism of the human olfactory receptor OR51E2. MD simulations revealed that calcium ions play a key role in stabilising the inactive state of the protein. This study …
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Einfluß der extrazellulären Ca2+-Konzentration und des Aktinfilamentsystems auf die homophile Interaktion von VE-Cadherin
… Ca2+ könnte seinerseits über Aktivierung von Gelsolin zur Fragmentation von Aktinfilamenten führen und so die Adhäsion weiter schwächen.
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The dynamics and regulation of actin filaments in vascular endothelial cells and in a reconstituted purified protein system
… attributed to ADF/cofilin in vitro. Removal of gelsolin in fibroblasts produces a similar correlation between motility, t, and PF. Consistent with increased actin filament severing, fast-moving endothelial cells have an increased number of short actin filaments and more uncapped barbed ends, but …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… targets histone deacetylase 3 (HDAC3) and gelsolin (GSN). HDAC3 cleavage was observed during early stages of hypertrophy and reduced in the presence of a caspase inhibitor. Caspase-mediated GSN cleavage occurred at latter stages, coincident with the cytoskeletal alterations that occur …
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Cloning and characterisation of a Dictyostelium STE20-like protein kinase DST2
… discoideum which phosphorylates severin, a gelsolin-like F-actin fragmenting protein. DST2 was discovered by screening of the D. discoideum cDNA project database using DST1 as query. To confirm the existence of the DST2 gene and its expression, Southern, Northern and Western analyses of DST2 …
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Estudo do papel do lpg2 na migração de células dendríticas infectadas por Leishmania infantum
… to assess podosome formation; and Rac1, Cdc42, Gelsolin, RhoA, and phalloidin to evaluate actin polymerization using confocal microscopy. Furthermore, the expression of CCR7 in dendritic cells infected by different Leishmania strains was assessed by flow cytometry. Finally, to investigate the …
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Charakterisierung des Zytoskelett-Proteins Villidin und einer dritten Profilin-Isoform in Dictyostelium discoideum
… of the protein, villidin can be assigned to the gelsolin/villin-family as well as to the WD-repeat family. In principal, the group of the WD-repeat proteins includes regulatory proteins which are involved in signal transduction and other important cellular processes. The N-terminus of villidin …
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Analyse der Zellsortierung und Zellbewegung von Dictyostelium discoideum mittels konfokaler 4DMikroskopie
… als auch Glorin sekretiert. Severin ist ein mit Gelsolin verwandtes 40 kDa Protein, das F-Aktin-Filamente fragmentiert und an das (+)-Ende des entstehenden Fragments bindet. Mit Hilfe eines GFP-Fusionsproteins wurde die intrazelluläre Lokalisierung dieses Proteins in vivo während einer Vielzahl …
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Neuroprotective effects of the dual glycogen synthase kinase-3b and phosphodiesterase 7 inhibitor VP3.15 and of an enriched environment in germinal matrix-intraventricular hemorrhage
… following the insult. Interestingly, plasma gelsolin levels (p-GSL), a feasible biomarker of brain damage, improved after VP3.15 treatment. Altogether, our data support the promising effects of VP3.15 to halt and reduce central nervous system complications associated with GM-IVH of the PT. In …