Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"gelatinases"”.
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The Gelatinases and Autoimmune Disease
<p>Matrix metalloproteases (MMPs) are critical to an array of homeostatic processes but have also been implicated in many pathological states. The roles they play in innate immunity, regulation of physical barriers such as the blood brain barrier, and the healing process are the same ones that …
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Plasma and leukocyte gelatinases in health and disease
Includes bibliographical references.
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
… blood brain barrier and as predicted inhibits gelatinases. We have also found the PKC activator, Bryostain-1, increased the average life span in HD R6/2 treated mice.</p>
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… MMP inhibitor SB-3CT, which is selective to gelatinases (MMP-2/-9). SB-3CT has been shown to attenuate MMP-9 and ameliorate neurological deficits after TBI.
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Characterisation and modulation of the gelatinase system of human Bruch's membrane
… existence of a free-bound equilibrium for the gelatinases with the bound forms being retained by hydrophobic, ionic or metal mediated interactions. Since divalent metal ions are deposited in Bruch’s of AMD donors, metal chelation was assessed as a possible means of inducing MMP release. Metal …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… process requires both chemokine cues and the gelatinases MMP2/9. Animals deficient in these MMPs show leukocyte accumulation in the perivascular space and are resistant to EAE. There are no reports in the literature on possible CB2R agonist effects on gelatinases in myeloid cells. Although …
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The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… The level of EGF, a potent inducer of gelatinases, is known to be elevated in the lungs during tissue repair in CF. Calu-3 cells preincubated with EGF on the basolateral membrane increased initial current at one hour via a EGFR-PI3K-PKC-δ-KCNN4/KCNQ1 signalling pathway. Similarly, …
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Angiogenesis and angioregression gene expression analyses in swine corpus luteum
… of the Ca++/Mg++-dependent endonucleases and gelatinases (MMP-2 and MMP-9). Three experiments were conducted to reach such objectives in CLs isolated from ovaries of cyclic, pregnant or fasted gilts. In the Experiment I, we evaluated the influence of acute fasting on VEGF production and VEGF, …
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Matrix Metalloproteinases 2 and 9 in Normal Canine Cerebrospinal Fluid
… and wound healing. One class of MMPs, the gelatinases, degrade gelatins and type IV collagen include MMP 2 and MMP 9. MMPs are important in many pathological processes that involve unregulated matrix destruction such as arthritis, neoplasia and CNS diseases. MMP2 is known to be …
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… tumor migration and survival. We identified two gelatinases, MMP-2 and MMP-9, to be expressed in Rb cell lines and demonstrated by pharmacological inhibition and genetic knockdown, a role for these gelatinases in Rb cell migration, invasion, and survival. Additionally, we demonstrated how …