Global ETD Search
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Showing 1 to 20 of 41 for “"gelatinase"”.
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Characterisation and modulation of the gelatinase system of human Bruch's membrane
… of central vision. In the present thesis, the gelatinase system (constituting MMPs 2&9) has been examined resulting in the identification and characterisation of three additional high molecular weight species termed HMW 1&2 and a large macromolecular weight MMP complex (LMMC). HMW1&2 were shown …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
Neutrophil gelatinase-associated lipocalin (NGAL), also called lipocalin-2, is a secreted protein belonging to the lipocalin family proteins and actively participates into the proliferation, differentiation, and development of human tissues, including tumours. It positively modulates the activity …
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Die Expression und Lokalisation von Matrix Metalloproteinasen (MMP) und ihrer spezifischen endogenen Inhibitoren (TIMP) in menschlichen primären Gehirntumoren
… Mikroskop.Es zeigte sich für mt1-MMP und Gelatinase A eine Zunahme der jeweiligen mRNA Spiegel mit dem Malignitätsgrad. Gelatinase B und TIMP-1 waren in den Glioblastomen erhöht. Mt2-MMP und TIMP-2 waren in allen Proben etwa gleich stark exprimiert, mt3-MMP, mt4-MMP und TIMP-3 waren in …
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Staphylococcus aureus의 Lipoteichoic acid(LTA)에 의한 사람의 정상 코 점막 상피세포에서의 MMP와 TIMP의 발현
… assay(ELISA) F. Gelatin zymography 1. Gelatinase B의 준비, 활성화 2. Gelatinase B의 전기영동, 기질-효소 간 반응 3. 발현된 band의 염색, 결과의 수치화 G. Western blot 1. LTA 처리, 단백질 정량 2. 단백질의 전기영동, Antibody 반응 H. MEK1/2 inhibitor에 의한 MMP-9의 발현 억제 확인 Ⅲ. 결과 A. LTA에 의한 코 점막 상피세포의 세포독성 확인 B. MMP-9와 TIMP-1, -2 유전자의 발현 차이 …
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Observing Renal Responses to Endurance Cycling in the Heat
… ELISA kit was used to measure serum neutrophil gelatinase-associated lipocalin. RESULTS: A net fluid loss of 1.3 ± 1.1 kg was observed. Urine specific gravity (P < 0.001) and leg muscle pain (P < 0.001) increased post-event. Serum creatinine increased from pre- (0.52 ± 0.14 mg/dL) to post-event …
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Applications Of Electronic Structure Theory To Problems In Unimolecular Dissociation And Inorganic And Biochemical Systems
… is a potent, mechanism-based inhibitor of the gelatinase sub-class of the matrix metalloproteinase (MMP) family of zinc proteases. The gelatinase MMPs are unusual in that there are several examples where both enantiomers of a racemic inhibitor have comparable inhibitory abilities. SB-3CT is one …
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The Role of Extracellular Matrix and Matrix-Degrading Proteases in Neonatal Hypoxic-Ischemic Injury
… relative contributions of resident microglia and gelatinase activity to the inflammatory sequelae. Results showed that both compounds blocked the OGD-induced increase in gelatinase activity and were neuroprotective in the absence of peripheral immune cells. Taken together, these data indicate that …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
… from each time point was also evaluated using gelatinase zymography to detect MMP-2,9, and 14. The endothelin assay was able to detect ET-1 in CSF as determined by a spike and recovery method. However, ET-1 was undetectable in CSF of control and hypothyroid dogs at all time points. …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… and zymography. There was an increase in gelatinase activity of secreted MMP-9 which was maintained between the 1 and 18-hour time points. The fold difference in activity between uninfected and infected declined at 24 hours, and at the 72-hour time point the uninfected was slightly higher …
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Predictive Role of NGAL – Neutrophil Gelatinase-Associated Lipocalin as an Early Marker for Renal Injury in Patients with Diabetes Mellitus Type 1 And Type 2 // Предиктивна роля на NGAL – неутрофил гелатиназа асоцииран липокалин като ранен маркер за бъбречно увреждане при пациенти със ЗД тип 1 и ЗД тип 2
Дисертационният труд разглежда ролята на Неутрофил гелатиназа-асоцииран липокалин (NGAL) като маркер за бъбречно увреждане при пациенти със захарен диабет (ЗД). Съществен принос са определените възрастово и полово диференцирани референтни граници на pNGAL, uNGAL и uNGAL/uCreatinine (UNC) за …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… addition, MLK4 blocks matrix metalloproteinase-9 gelatinase activity and invasion in SKOV3 ovarian cancer cells, both of which are cellular responses that require MLK3. Collectively, our data establish MLK4beta as a novel suppressor of MLK3 activation, MAPK signaling and cell invasion.
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Elucidating the Molecular Function of Reprolysin Metalloproteases in Tick-Host-Pathogen Interaction
… proteolytic activity, degrading fibrinogen and gelatinase activity, as well as disturbing homeostasis<sup>1</sup><sup>2</sup>. Previous work with the <em>Amblyomma americanum</em> sialotranscriptome identified over 40 metalloproteases secreted in the saliva during the ticks’ feeding. <em>A. …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… that there is an elevation of MMPs, specifically gelatinase MMP-9, in the brain tissue of mice with TBI. In the Gu laboratory, we have adopted an electromagnetic (EM) controlled cortical impact (CCI) mouse model along with refined surgical techniques and behavioral testing to mimic a precise, …
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Evaluating The Impact of Post-Translational Modifications By The Secreted Zinc Metalloprotease, Gele, On The Major Autolysin of E. Faecalis, Atla, and A Stress-Induced Protein, Salb
… appear to be affected by the virulence factor, gelatinase (GelE). GelE is a secreted zinc metalloprotease known to impact various cellular functions by post- translational modification of protein substrates. The overall objective of this work was to understand how GelE cleavage of secreted …
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The Role of Type VIII Collagen in Fibrous Cap Formation and Progression of Atherosclerosis
… SMC and fibrillar type I collagen content and gelatinase activity. Reduced fibrous cap thickness and increased necrotic core size were observed in plaques from these mice. The second study shows that the advanced plaques from mice deficient in type VIII collagen have increased macrophage …
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Migration Stimulating Factor, the search for inhibitors.
… which identified the inhibitor as Neutrophil Gelatinase Associated Lipocalin (NGAL). Both recombinant and cell-produced NGAL neutralise the motogenic activity of MSF. This novel bioactivity for NGAL is not dependent on its iron transportation capability or direct binding to MSF. HaCaT cells …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… cytotoxic granule (NE, resistin and neutrophil gelatinase-associated lipocalin) and cytoplasmic (cyclophilin A) proteins under hypoxia. Furthermore, a plasma signature of increased protease (NE and proteinase 3) activity was identified in COPD versus healthy control plasma. In conclusion, …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… which promotes transcription of neutrophil gelatinase associated lipocalin (NGAL), an antibacterial protein positively correlated with UC severity. Accordingly, we hypothesized that CA would upregulate the NRF2 and decrease inflammation in intestinal inflammation models. We used UC …
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OPTIMIZING DIAGNOSTIC ACCURACY IN CANINE URINARY TRACT INFECTIONS: FUTURE DIRECTIONS TO REDUCE ANTIMICROBIAL MISUSE IN VETERINARY PRACTICE
… UTI is evaluated, including urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary interleukins 8 and 6, urinary xanthine oxidase, and urinary myeloperoxidase. Among these, urinary interleukin-8 and urinary xanthine oxidase are identified as the most promising disease markers, …
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Chemical and biological modification of porous silicon photonic crystals.
… culture results in optical detection of released gelatinase enzymes. The generality of the surface chemistry allows for a range of other biological applications to be investigated. An alternative biorecognition interface, hybrid lipid bilayer membranes, containing specific recognition elements for …
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