Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"gefitinib"”.
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… with 10 μM of type I tyrosine kinase inhibitors Gefitinib (Iressa®, Astra Zeneca), CI-1033 (Canertinib, Pfizer), or Dimethyl Sulfoxide vehicle. Cells were exposed to each drug treatment as part of a time course ranging from 0 to 24 hours and then evaluated by trypan blue exclusion and Western …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… evidence of potential PPARγ partial agonism by gefitinib and ENL. Evaluation of the expression changes of several fibrotic markers (e.g., collagen I, -SMA, MMP2/MMP9, and TIMP-1,) using human hepatic stellate cells (HSC), LX-2 cells, at both mRNA and protein level by real-time PCR and …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… molecule tyrosine kinases inhibitors of EGFR gefitinib and erlotinib, the monoclonal antibody against EGFR cetuximab, and the multi-target tyrosine kinase inhibitor dasatinib. Significantly higher EGFR expression was detected in TNBC compared to HER-2 positive breast cancer cell lines. EGF …
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
… of three tyrosine kinase inhibitors (TKIs), gefitinib, erlotinib and lapatinib, to circumvent resistance to docetaxel, and other chemotherapeutic agents, arising from P-gp over-expression. A HPLC – based method was initially employed to quantify docetaxel levels in cells. The very high taxane …
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Can Medicare afford to pay for oral chemotherapy drugs? : an evaluation of the problem and introduction of a model to estimate cost
… Medicare program to cover all oral cancer drugs. Gefitinib (Iressa; AstraZeneca) is one of the most interesting of the cohort of novel, targeted oral cancer drugs. Already approved in Japan, it is currently under review by the U.S. FDA. This drug has relatively modest efficacy and few side …
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The significance of the EGFR pathway in malignant pleural mesothelioma
… mutations. Cells were incubated with Cetuximab, Gefitinib, Rapamycin, Ku0063794 (MTOR kinase inhibitor) and Celecoxib as single agents and in combinations and analysed using the MTS assay.ResultsPositive 5-LOX expression was seen in 73% and positive 12-LOX expression was seen in 83% of MPM …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… chamber. Four small molecular inhibitors: gefitinib, erlotinib, lapatinib and wortmannin), and four natural agents: resveratrol, caffeine, anthocyanins, and protocatechuic acid), were considered as examples of single agents. Gefitinib and erlotinib were delivered in an aerosol form to …
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The role of ErbB inhibitors in promoting nerve regeneration in a mouse model of nerve injury
… inhibitor lapatinib or the ErbB1 inhibitor gefitinib could promote nerve regeneration in both in vivo and in vitro models. Using a mouse transection and repair sciatic nerve injury model, lapatinib was found to increase the number of regenerated myelinated axons at 28 days following nerve …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
… More recently the Tyrosine kinase inhibitors (Gefitinib and Erlotinib) have been investigated as drugs to target tumours with EGFR mutation. These inhibitors bind to the cytoplasmic domain of the EGFR and compete with ATP and inhibit phosphorylation of the receptor. Another inhibitor of …
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Pharmacological modulation and manipulation of cancer drug resistance
… (17-AAG, lapatinib, indomethacin, elacridar and gefitinib) down-regulated the expression of BCRP in the DLKP-SQ/mitox cell line. Lapatinib, gefitinib, elacridar and 17-AAG overcame BCRP-mediated resistance in both the combination and pre-treatment proliferation assays. The data indicates that the …
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The Investigation of Targets for Therapy in Brain Tumours
… their responsiveness to three TKIs, erlotinib, gefitinib and imatinib, and two chemotherapy drugs, docetaxel and temozolomide. All data of 26 high-grade gliomas (20 primary glioblastomas, 2 secondary glioblastomas, and 4 grade III astrocytomas including medical history of the patients were …
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Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response
… or pretreatment with an EGFR kinase inhibitor gefitinib blocks EGFR and ATM association, hinders CHK2 activation and subsequent foci formation, and increases radio-sensitivity. Thus, we reveal a critical mechanism by which EGFR directly regulates ATM activation in DNA damage response and ATM …
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Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… (EGFR), EGFR targeted inhibitors, such as gefitinib (GEF), have yet to demonstrate efficacy. Using mass spectrometry to identify pathways that remain activated in the presence of GEF, we found that components of the mTOR signaling pathway remain phosphorylated. While inhibiting mTOR with …
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Analysis of anti-cancer drug penetration through multicell layers in vitro. The development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissues.
… of penetration of doxorubicin, imatinib and gefitinib were respectively 42, 26 and 13 folds greater than when no CFF exists. Reversing the CFF so that it opposed the drug diffusion gradient significantly impairs drug penetration. In conclusion, a novel in vitro model for assessing the impact …
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EGFR in Early Non-small Cell Lung Cancer: Tyrosine Kinase Inhibition in a Neoadjuvant Trial
… we implemented a phase II trial of neoadjuvant gefitinib in clinical stage I NSCLC. Tumour shrinkage was seen in 43% of patients, with 11% achieving RECIST partial response (PR). Analysis of molecular markers showed EGFR TKD mutations in 17% of cases, being the only associated with PR. For the …
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Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen
… factor)-Rezeptor-assoziierten Tyrosinkinase Gefitinib dephosphorylierte bei T47D-TR ebenfalls phospho-Akt und resensibilisierte die Zellen für Tamoxifen. Bei MCF-7-TR gelang erstmals eine Resensibilisierung Antiöstrogen-resistenter Zellen mit dem potentiellen Akt-Inhibitor Perifosine. Eine …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… breast cancer cell lines to the EGFR TKI gefitinib. Importantly, the effects of cholesterol lowering drugs and EGFR TKI in combination were synergistic. We have shown that the non-receptor tyrosine kinase c-Src, which is co-over-expressed with EGFR in a subset of breast tumors, also …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… resistant human breast cancer cells to the TKI, gefitinib; in a diabetic retinopathy model, CAT-SKL significantly reverses compromised retinal function; and in a rat cell model of Alzheimer's disease, β-amyloid peptide-induced neuronal toxicity is significantly reduced.</p>
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… to epidermal growth factor inhibition (i.e., gefitinib). We studied promoter methylation in 70 human non-small cell lung cancer cell lines and discovered that <em>CXCL5</em> was regulated by promoter methylation. We concluded that the <em>CXCR2 </em>axis may be an important target in …
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Spray Techniques And Lung Cancer Chemoprevention
… form due to its low bioavailability in the lung. Gefitinib and erlotinib were delivered via aerosols to decrease the dose to prevent severe skin toxicities associated with high dosages. The effect of aerosolized budesonide was studied. It was further combined with diet Polyphenon E, diet …
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