Global ETD Search
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Showing 1 to 3 of 3 for “"gating spring"”.
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The Nanomechanics of Protocadherin 15, A Protein Essential for Human Hearing
… the inner ear. A mechanical element called the gating spring modulates the mechanotransduction channel's open probability by changing the force transmitted to the channels. The molecular identity of the gating spring is yet unconfirmed, but a leading candidate is the filamentous tip link …
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Finite-element analysis of inner ear hair bundles: a parameter study of bundle mechanics
… to bundle stiffness and each could act as the gating-spring in transduction models, which propose gating structures as a means of regulating ionic activity and therefore neural activity. Stiffness depends most strongly on individual stereocilium geometry and material description, tip-link …
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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System
… greater than that of the empirically measured gating spring. To remain a viable candidate as a compliant element, entropic elasticity in the tip link must therefore be shown to support the full frequency and intensity range of auditory stimuli. In the present work, we model the tip link as a …