Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 410 for “"gating"”.
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Molecular Determinants of TRP Channel Gating
<p>Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This …
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Scaling and Gating Attosecond Pulse Generation
High-order harmonic generation (HHG) provides the basis for attosecond light sources delivering coherent pulses in the extreme ultraviolet spectral region. Such light sources are employed for a variety of applications within imaging, attosecond spectroscopy, and high-precision frequency metrology. …
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Influence of Age on Auditory Gating
… a 10 s interstimulus interval to assess sensory gating. Forty-two participants, ranging from 3-72 years of age were used to observe maturational changes in amplitude, latency, and suppression ratios of the P50 waveform. Previous research has shown that in normal adults the amplitude in response …
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Voltage-Gating Mechanism in Potassium Channels
… investigate the ion permeation, as well as the gating mechanism of voltage-gated potassium channels. The atomic-resolution structures of Kv1.2 in the active and resting state conformations are refined in an explicit representation of the membrane environment. The gating charge of the Kv1.2 …
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Voltage-Gating Mechanism in Potassium Channels
… investigate the ion permeation, as well as the gating mechanism of voltage-gated potassium channels. The atomic- resolution structures of Kv1.2 in the active and resting state conformations are refined in an explicit representation of the membrane environment. The gating charge of the Kv1.2 …
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Ion Selectivity and Gating in the NAK Channel
Ion selectivity and gating are two fundamental properties central to proper physiological functioning of ion channels. In this work, a thorough structural characterization of ion binding profiles is presented for the NaK channel, a non selective cation channel from Bacillus cereus, along with an …
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Single-Molecule Studies of CFTR Gating and Pharmacology
… sites for therapeutic potentiators of CFTR gating are known, the mechanism by which they increase channel open probability is not understood. In this thesis, I combined ensemble functional measurements, single-molecule fluorescence resonance energy transfer imaging, electrophysiology, …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… of TMEM16A and the long-range allosteric gating mechanism via the third Ca2+ binding site; they also provide functional insight into the structural organization of TMEM16 ion channels and lipid scramblases. </p>
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VAST-LP: clock gating in high-level synthesis
… VAST and propose a method to generate clock-gating-friendly RTL code for downstream logic synthesis tools. We use one-hot-key encoding method to build the state tran- sition in hardware, and we use the state registers along with main clock signal to generate subclock signals. By analyzing the …
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Structural insights into the GABAA receptor gating cycle
… suggested that the GABA<sub>A</sub> receptor gating motions might include conformations that diverge considerably from the pseudo-symmetric arrangements observed previously. To test whether the asymmetry observed is physiologically meaningful, and to achieve a comprehensive characterisation of …
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RT-Level power-gating models optimizing dynamic leakage-management
Power-Gating ist die vielversprechendste zur Laufzeit angewandte Technik, um Leckströme in Sub-100nm CMOS Transistoren zu verringern. Ihre Anwendung ist aber mit Zahlreichen Problemen wie Mehrkosten in Fläche und Energie und eine Verlangsamung der Schaltung verbunden. Generell ist eine Vorhersage …
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Gating Mechanisms of The Canonical Trp Channel Isoform Trpc4
<p>Non-selective cation channels formed by Transient Receptor Potential Canonical (TRPC) proteins play important roles in regulatory and pathophysiological processes. These channels are known to be activated downstream from phospholipase C (PLC) signaling. However, the mechanism by which the PLC …
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Multi-functional Hybrid Gating Silicon Nanowire Field-effect Transistors
Enormous demands for fast and low-power computing and memory building blocks for consumer electronics, such as smartphones or tablets, have led to the emergence of silicon nanowire transistors a decade ago. Along with the Si-based nanotechnology, the silicon compatible optical and chemical sensing …
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Protein-Protein-Interaktionen in den 'Gating'-Domänen von Kaliumkanälen
… gesteuert werden. In dieser Arbeit wurde das 'Gating' zweier Kanaltypen auf molekularer Ebene untersucht: die Aktivierung bzw. Deaktivierung von Ca2+-gesteuerten SK-Kanälen sowie die Inaktivierung von spannungsgesteuerten Kv-Kanälen. Die einzelnen Projekte wurden in interdisziplinärer …
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Gating Methods for High-Voltage Silicon Carbide Power MOSFETs
<p>The objective of this thesis is to assess the challenges associated with driving Silicon Carbide (SiC) power devices, and to compare the potential gate drive methods for these devices which address those challenges. SiC power devices present many benefits that make them suitable for next …
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Molecular mechanisms of gating and selectivity in transport channels
Transport channels and pores are of fundamental importance for translocation of molecules across the otherwise-impermeable biological membrane. As a conduit for the passage of material, specific membrane channels must accomplish the task of selective transport of molecules, while preventing …
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Emerging Power-Gating Techniques for Low Power Digital Circuits
… an industry-standard technique known as power-gating is explored, whereby transistors are used to disconnect the power from idle portions of a chip. Present power-gating implementations suffer from limitations including non-zero off-state leakage, which can aggregate to a large amount of wasted …
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Characterization of cardiac IKs channel gating using voltage clamp fluorometry
… the mechanisms underlying the voltage-dependent gating of a member of the voltage gated potassium (Kv) channel family, KCNQ1 (Kv7.1). Like other members of the voltage gated potassium family, the KCNQ1 channel is made up of four subunits, each containing a voltage sensing domain and a …
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An apparatus for frequency resolved optical gating of attoseconds pulses
… of an apparatus for frequency resolved optical gating of attosecond pulses. Frequency resolved optical gating is the state-of-the-art technique for measuring the temporal profile of attosecond optical pulses. In this thesis, I discuss the operation of the apparatus in the context of the …
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Dynamic modulation of material properties by solid state proton gating
… heterostructures using solid state proton gating in a metal/oxide heterostructure. We also demonstrate dynamic modulation of magnetic anisotropy at a metal-metal interface through hydrogen insertion in a heavy metal adjacent to a ferromagnet. Besides magnetic properties, solid state proton …
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