Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"gastrointestinal toxicity"”.
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Identifying potential genetic, phenotypic and epigenetic predictive markers in the Toll-like receptor/Interleukin-1 domain innate immune signalling pathway for severe gastrointestinal toxicity risk following 5-Fluorouracil-based therapy
Severe gastrointestinal (GI) toxicity symptoms such as diarrhoea, mucositis, nausea and vomiting are adverse side effects following 5-fluorouracil (5-FU)-based therapy. Current supportive care measures for the treatment of severe GI toxicity are limited, with many patients requiring treatment …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… drugs that spare COX-1 have exhibited less gastrointestinal toxicity, but no NSAID has been proven safe for the kidney. The kidney is the organ with the second highest reports of adverse drug events, which is usually manifested as functional changes. However, structural changes including …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… supplementation was, however, associated with gastrointestinal toxicity in some mice. Liquid chromatography-mass spectrometry demonstrated the accumulation of high levels of flavonoid in the prostates of TRAMP mice. These findings lay the foundation for further studies of flavonoids in clinical …
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Effect of diet on methotrexate toxicity
… effects of different diets and regimens on gastrointestinal toxicity induced by methotrexate (MTX) in rats. Toxicity was determined by severity of anorexia and incidence of diarrhea on d 3 and 4 following an intraperitoneal injection of 20 mg MTX per kg body weight. Rats adapted to a …