Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"gastrointestinal (GI) tract"”.
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Encapsulation of tributyrin using various techniques to improve its intestinal delivery and sensory quality
Over 60 million Americans suffer from gastrointestinal (GI) tract related issues, which affect not only the quality of patients’ lives but also create a medical burden of over 140 billion USD per year. Tributyrin (TB), a source of butyrate, has been reported for its benefits to the gastrointestinal …
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Surface Models of the Gastrointestinal Tract and Neighboring Structures Made from the Visible Korean Human
Surface models of the gastrointestinal (GI) tract and neighboring abdominal structures can be opened and rotated in a real time, which is helpful to understanding anatomy of digestive system. However, we could not find objective surface models made from the serially sectioned images. In order to …
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Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System
… of a series of interconnected ganglia within the gastrointestinal (GI) tract, formed during development following the migration of enteric neural crest cells (ENCCs) into the primitive gut tube. Much work has been done to unravel the complex nature of extrinsic and intrinsic factors that regulate …
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Using high-density mutagenesis to identify the genetic requirements for the growth of Escherichia coli
… is highly adapted to life within the mammalian gastrointestinal (GI) tract, capable of adapting to multiple environments en route to colonising the intestine. Moreover, the means by which the species copes with changes in the microenvironments of the GI tract strongly influences the nature of E. …
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Ingestible capsules for therapeutic injections in the gastrointestinal tract
… rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limits their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. In this thesis I will describe two oral capsules …
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Ingestible Electronics for High Quality Gastric Neural Recordings
… in understanding the gut-brain axis, functional gastrointestinal disorders, and gastric stimulation therapies have highlighted the importance of the electrical signals that regulate the gastrointestinal (GI) tract. Current systems for measuring neural signals from the GI tract involve acute, …
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Engineering Medical Devices to Improve Oral Delivery of Biopharmaceuticals
The dynamic mechanics of the gastrointestinal (GI) tract, including gut contractions, variable pH, and degradative enzymes, significantly challenge the development of oral delivery systems for biologic drugs by compromising their reliable delivery and therapeutic efficacy. While recent advances in …
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The association between oral health, related bacteria and gastrointestinal cancer risk and progression
… these cases were attributable to cancers of the gastrointestinal (GI) tract. Cancer incidence and mortality rates have rapidly increased in the 21st century, due to several factors including the global adoption of the western lifestyle and longer life expectancies.<br/><br/>Previous research has …
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BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE
The gastrointestinal (GI) tract is a hollow muscular tubular organ that extends from the mouth down to the rectum. Different high pressure zones exist along the tract and are referred to as sphincters. Sphincters maintain a closure tone and relax upon receiving the appropriate signal to allow …
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Characterization of the intestinal microbiome and lactobacilli community: influence of dietary and environmental factors
The human gastrointestinal (GI) tract is colonized by a dense and diverse bacterial community called the commensal microbiota, which plays an important role in overall health of individuals. However, due to the extreme complexity of microbiota composition and limits of research tools, there were …
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Design of a large-dose minimally invasive drug delivery device for Tuberculosis
… million individuals annually. The TB treatment regime is quite involved, generally requiring six months and multiple medications. A lack of medication adherence can lead to drug-resistant TB. One current method to improve adherence requires the medicine to be dispensed multiple times a week at …
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A mouse model for studying gastrointestinal microbial ecology
The mammalian gastrointestinal (GI) tract harbors a complex microbial ecosystem with hundreds of bacterial species at total levels as high as 10¹¹⁻¹² cells/g tissue. These bacteria play an important role in the health of the host as well as in causing disease, but studies on the roles of the GI …
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Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging
Diseases of the gastrointestinal (GI) tract are typically diagnosed by random biopsy of tissue, which samples only a small area and often misses focal neoplasias. Existing endoscopic visualization tools including white light endoscopy, narrowband imaging and confocal laser endomicroscopy have …
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Process-induced changes on the functionality of oat β-glucan evaluated using a gastrointestinal simulation model
… oat β-glucan are proposed to be related to its extractability, molecular weight (MW), and viscosity enhancement in the gastrointestinal (GI) tract. The aim of this work was to understand how changes induced during the processing of oat-based bread and meat analogs influence the macromolecular …
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Gastrointestinal microbiota community composition has significant effects on systemic immune responses
… systemic immune responses. Colonization of the gastrointestinal (GI) tract is initiated during birth and continually seeded from the individual’s environment. Gastrointestinal microorganisms for a mutualistic relationship with the host, playing a central role in developing and modulating host …
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Personalized absorbable gastrointestinal stents for intestinal fistulae and perforations
Gastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen …
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Gastrointestinal Influences on Poliovirus Replication, Dissemination and Pathogenesis in Mice
… encounter a complex environment within the gastrointestinal (GI) tract, including pH changes, mucus, resident bacteria and a variety of epithelial and immune cell types. Little is known about how factors within and comprising the GI tract influence viral replication, dissemination and …
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Morphometric characterization of individual sympathetic postganglionic axons innervating the muscle layers of the gastrointestinal tract of the rat: A complex effector model
… axons innervating the musculature of the gastrointestinal (GI) tract has not been available. Furthermore, common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of the techniques employed to distinguish the …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… transplantation (HSCT), resulting from immunological attack on target organs such as gastrointestinal (GI) tract, liver and skin from donor allogeneic T cells. The most common treatment for GVHD is immunosuppressive drugs such as corticosteroids, which may result in many side effects including …
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