Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"gastrin-releasing peptide"”.
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… Our lab and others have shown trophic actions of gastrin-releasing peptide (GRP), and its analogue bombesin (BBS), in neuroblastomas. Our lab also found that undifferentiated neuroblastomas express increased levels of GRP receptor (GRPR). Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt …
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Exploring the role of Gastrin-Releasing Peptide Neurons in Circadian Time-Keeping of the Suprachiasmatic Nucleus
… and the intercellular network, in which neuropeptidergic signalling couples cell-autonomous rhythms across the SCN. One of several neuropeptidergic axes of the SCN is that formed by cells that express Gastrin-Releasing Peptide (GRP) and cells that express its cognate receptor (GRPR). Although …
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific …
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Molecular Mechanisms of Itch Sensations
… itch sensory mechanisms is still primitive. Gastrin-releasing peptide receptor: GRPR) was identified as the first itch-specific receptor in the spinal cord. GRPR cell ablation by bombesin-saporin abolished general scratching responses to pruritogens. Because GRPR mutant mice still have …
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The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
… dual PET/fluorescence imaging agents based on peptides as targeting entities. Porphyrins are suitable for multimodality imaging applications due to their innate characteristics such as an ability to fluoresce and to coordinate metals. A gallium-protoporphyrin IX(PPIX)-ghrelin based analogue was …
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From structural dynamics to drug repurposing: computational approaches in the context of precision medicine
… with Somatostatin Receptors (SSTRs) and the Gastrin-Releasing Peptide Receptor (GRPR) standing as highly promising candidates due to their overexpression in various cancers and diseases. Furthermore, the enzyme Cluster of Differentiation 38 (CD38), which is implicated in aggressive …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Hypothalamic Mechanisms of Food Intake in Birds
… found in the blood stream and subsequent neuropeptide and neurotransmitter signaling in the hypothalamus. External factors, such as high ambient temperature (HAT), can indirectly affect appetite regulation through other neuroendocrine systems such as the hypothalamo-pituitary-adrenal (HPA) …
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Arc expression in the parabrachial nucleus following taste stimulation
… then established to investigate possible neuropeptide genes involved in neural responses to taste stimulation. The results showed that bitter taste stimulation induces increased Arc expression in the PbN in naïve mice. This was not true for other taste qualities. In mice conditioned to find an …
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Causal Gene Prioritization Across Diverse Diseases Through Multi-Omic Data Integration
… genetic support for therapeutic targets (e.g. as gastrin-releasing peptide for type 2 diabetes) and improving causal gene assignment at 40% (n=192) of overlapping GWAS loci. Building upon my previous work, I assembled and meta-analysed proteogenomic data from 38 international studies to conduct …
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Isolation and Characterization of Regulatory Peptides from Two Tetraploid Species, the Pallid Sturgeon, Scaphirhynchus albus, and the African Clawed Frog, Xenopus laevis
… different mutations and produce proteins or peptides with differences in their primary structures. The isolation of multiple forms of regulatory peptides from a single species is helpful in determining the ploidy status of the species, and comparisons of the primary structures of regulatory …
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Ανάπτυξη, βιοκατανομή και φαρμακοκινητική μελέτη πεπτιδικών αναλόγων μπομπεσίνης επισημασμένων με διαγνωστικά ραδιονουκλίδια για την αντιμετώπιση του καρκίνου
… του πεπτιδίου απελευθέρωσης της γαστρίνης (gastrin-releasing peptide receptors, GRPrs), οι οποίοι υπερεκφράζονται στην επιφάνεια διαφόρων τύπων καρκινικών κυττάρων. Οι υποδοχείς GRP δυνητικά θα μπορούσαν να θεωρηθούν ιδανικός στόχος για την απεικόνιση νευροενδοκρινικών όγκων μετά από …