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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"gastrin"”.
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The Structural Requirements of Gastrin and Glycine-Extended Gastrin for Binding to Receptors from Normal and Cancerous Human Tissues
Structural requirements for binding of gastrin to the human CCK2 receptor and the existence of receptors for gastrin peptides on human colon cancer cells were investigated. CCK2 receptor studies focused on the importance of the C-terminal Phe and putative P- tum region of gastrin 17 (G17). Gastrin …
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Satiety induced by neuropeptide FF and gastrin in birds
… to vehicle-injected controls. In a second study, gastrin was ICV injected into broiler chicks and decreased food intake at a dose of 500 ng (0.12 nmol). There was increased c-Fos immunoreactivity in the lateral hypothalamus (LH), paraventricular nucleus (PVN), arcuate nucleus, nucleus of the …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… a broad-based microarray screen, the preprogastrin gene was found to be differentially expressed in our model of beta cell cytokine resistance, the INS-1res cell lines compared to unselected INS-1 cells. As a result of this finding, preprogastrin was initially evaluated for its involvement …
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Study of Receptor Binding and Growth Effect of Gastrin Gene Products
… for 160,000 cases and 57,000 deaths per year. Gastrin (G17) has been postulated as a growth factor for colorectal cancer development. Gastrin, a heptadecapeptide, is a gut hormone produced by the G cells in the gastric antrum and functions primarily in stimulating acid secretion from the …
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Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat
… in the acid-producing part of the stomach. Gastrin from G cells in the antrum is the main stimulus of gastric acid secretion. Gastrin stimulates the ECL cells in the oxyntic mucosa to mobilize histamine, which in turn stimulates the parietal cells to produce hydrochloric acid. In the present …
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Aspects of structure-activity relationships and physiology of gastrin and related peptides
… in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable at …
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… Our lab and others have shown trophic actions of gastrin-releasing peptide (GRP), and its analogue bombesin (BBS), in neuroblastomas. Our lab also found that undifferentiated neuroblastomas express increased levels of GRP receptor (GRPR). Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt …
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The Mechanism of the Action of Gastrin on Guinea Pig Ileum Smooth Muscle
… of the specific secretory hormone, gastrin. | Gastrin was discovered to have a spectrum of actions upon the gastrointestinal tract. Vizi et al. produced direct evidence that gastrin caused the release of acetylcholine from Auerbach's plexus of guinea pig terminal ileum which, in …
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Method of biological assay of Gastrin and its application to the study of human tissue
… of anaesthesia and duration of operation on the gastrin content, the rate of turnover of gastrin and the significance of a single estimate of extractable gastrin -like activity. Any comment on the above results must therefore be speculative.
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Exploring the role of Gastrin-Releasing Peptide Neurons in Circadian Time-Keeping of the Suprachiasmatic Nucleus
… of the SCN is that formed by cells that express Gastrin-Releasing Peptide (GRP) and cells that express its cognate receptor (GRPR). Although implicated in retinal signalling into the SCN, its general role in the SCN is unknown. This thesis aims to determine the contributions to SCN time-keeping …
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An investigation of the distribution of gastrin-like activity, and its nature, in the gastrointestinal tract of the sheep
… (1964), and a perfused rat stomach bioassay, gastrin-like activity has been located in the ovine rumen, reticulum, omasum, abomasal body, antrum, duodenum and caecum. The antrum showed the highest concentration of gastrin-like activity, but substantial concentrations were found in the rumen, …
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ΜΕΛΕΤΗ ΕΠΙ ΤΗΣ ΕΠΙΔΡΑΣΕΩΣ ΤΗΣ ΜΕΡΙΚΗΣ ΕΚΤΟΜΗΣ ΤΟΥ ΛΕΠΤΟΥ ΕΝΤΕΡΟΥ ΕΠΙ ΤΗΣ ΓΑΣΤΡΙΝΗΣ ΤΟΥ ΟΡΟΥ
… STUDY THE INFLUENCE OF SMALL BYPASS ON THE SERUM GASTRIN LEVELS WAS INVESTIGATED. THE MAIN CONCLUSIONS OF THE STUDY ARE THE FOLLOWING. 1) THE SMALL BOWEL TOGETHER WITH OTHER FACTORS GREATLY CONTRIBUTES TO THE NORMAL REGULATION OFTHE SERUM GASTRIN LEVELS. 2) THE SMALL BOWEL INHIBITS GASTRIN …
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Η ΣΥΜΠΕΡΙΦΟΡΑ ΤΗΣ ΓΑΣΤΡΙΝΗΣ ΤΗΣ ΙΝΣΟΥΛΙΝΗΣ ΚΑΙ ΤΟΥ C-ΠΕΠΤΙΔΙΟΥ ΤΟΥ ΟΡΟΥ ΚΑΤΑ ΤΗΔΙΑΡΚΕΙΑ ΤΗΣ ΕΓΚΥΜΟΣΥΝΗΣ ΚΑΙ ΤΗΣ ΛΟΧΕΙΑΣ ΣΕ ΘΗΛΑΖΟΥΣΕΣ ΚΑΙ ΜΗ ΘΗΛΑΖΟΥΣΕΣ ΜΗΤΕΡΕΣ
BLOOD LASTING GASTRIN LEVELS MARKEDLY INCREASE DURING PREGNANCY, AND REMAIN HIGH DURING LACTATION. IN NON LACTATING WOMEN THE GASTRIN LEVELS RETURN RAPIDLY TO NORMAL. INSULIN LEVELS PROGRESSIVELY INCREASE DURING PREGNANCY DURING PUERPERIUM THE INSULIN LEVELS SLOWLY RETURN TO NORMAL. THERE ARE NO …
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Duodenal pH : new aspects of physiology and pathophysiology
… of cephalic stimulation and a meal on plasma gastrin, secretin and somatostatin and duodenal pH were examined in healthy subjects and duodenal ulcer patients. The results showed: vagally-released gastrin is not a significant contributor to stimulation of gastric acid secretion in either health …
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Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
The contribution of the N-terminal region of gastrin-17 (G17) to the binding and activation of the putative gastrin processing intermediate receptor(s) on human colorectal cancer cells is investigated. The C-terminal sequence Trp-Met-Asp-Phe-NH2 has long been recognized to be essential to the …
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Structural characterisation of the solution and membrane-associated conformations of human little gastrin and its bioactive fragments by NMR spectroscopy and molecular modelling
… conformations of a series of DMSO solubilised gastrin peptides, G-4, [ß-Ala ¹] G-5 and G-17, so as to establish how the configurations of the biologically relevant sequence were related to each other, and to resolve whether they adopted preferred and conserved conformations in solution. …
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An investigation of novel biomarkers of gastric mucosal preneoplasia
… of H. pylori IgG antibodies, fasting gastrin and pepsinogens 1 and 2. Genomic DNA was extracted from blood samples. For each subject, we performed genotyping for nine single nucleotide polymorphisms in the MMP-7 gene to determine whether these polymorphisms might increase the …
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific …
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Molecular Mechanisms of Itch Sensations
… itch sensory mechanisms is still primitive. Gastrin-releasing peptide receptor: GRPR) was identified as the first itch-specific receptor in the spinal cord. GRPR cell ablation by bombesin-saporin abolished general scratching responses to pruritogens. Because GRPR mutant mice still have …
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Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes
… gluc a gon (IRG), pancreatic polypeptide (PP), gastrin, gastric inhibitory polypeptide (GIP) and somatostatin (SRIF-LI) have been undertaken in NIDDM. Studies were also carried out to assess whether AN may be implicated in abnormal release of these five gut hormones in diabetes and to determine …
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