Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"gastric pH"”.
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
… is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions with cellulose derivatives including: hydroxypropylmethylcellulose acetate …
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Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosis, are observed to cause gastrointestinal mucosa irritation, which leads to nausea, vomiting …
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Pharmacometric modeling and simulation of ranitidine In human gastric acid secretion.
Stress-related gastric mucosal damage commonly occurs in critically ill patients. Prophylactic therapy has become the standard in patients admitted to intensive care unit to prevent the significant morbidity and mortality associated with acute gastric hemorrhage. Ranitidine has been used widely to …
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The Role of Claudins in Bone Metabolism
… Cldn-18 knockout (KO) mice developed osteopenia phenotype by increasing bone resorption and osteoclast differentiation. Since Cldn-18 is known to be predominately expressed in the stomach, and it was globally disrupted in these earlier studies, in this dissertation we tested the possibility that …
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Duodenal pH : new aspects of physiology and pathophysiology
… is believed to centre around the presence of gastric acid, yet the exact role that acid plays is poorly understood. Previous investigations of the duodenal pH have been restricted by methodological and technical difficulties, and have, for the most part, only monitored the pH in the …
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Development and evaluation of a beta-glucan biopolymer formulation of lactoferrin produced using a novel cryomilling technique
… nutritional and biological applications. The physicochemical properties (rheological behaviour, mechanical strength, stress studies, molecular weight and density) of the β-glucan were investigated. Simulated gastric pH condition was found to have no effect on molecular weight and viscosity of …
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Effects of microbial phytase in pig diets on calcium requirements, post-weaning growth performance, phytate degradation, and nutrient digestibility
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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THE INTERACTION OF ACID-PRESERVATION OF WHEAT OR BARLEY, WITH OR WITHOUT ENZYMES, AND PARTICLE SIZE ON WEANLING PIG PERFORMANCE AND GUT HEALTH
… acidification and particle size both influence gastric pH and thus enzyme activity. In Chapter 2, bench-scale trials were conducted to determine the effect of acid preservation of high moisture wheat or barley (20% moisture) using propionic acid (Prop) or a phosphoric-acid-based …
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… even drug disposition processes. All aspects of physiologic development are governed in part by age from gastric pH, and kidney function, to skin thickness. With the knowledge that age is a major determinant of expression of drug metabolizing enzymes it was hypothesized that age would also impact …
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Quantification and alleviation of the antinutritional effects of phytate on poultry
The phosphorus (P) requirements of meat-type poultry cannot be met by plant-based diets because approximately two thirds of total phosphorus in cereals and leguminous feed materials is in the unavailable form of phytate (inositol hexaphosphate or phytic acid). Phosphorus supplements are expensive …