Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"gastric fluid"”.
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Investigation of Uniform Biomaterial-Based Microspheres With Precisely Controlled Size and Size Distribution for Development of Advanced Drug Delivery Systems
… CMS due to the smaller amount of release at the gastric fluid.
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Preparation and Evaluation of Cefuroxime Axetil Gastro-Retentive Floating Drug Delivery System for Improved Delivery via Hot-Melt Extrusion Technology
… studies were performed in 900 mL of simulated gastric fluid (without enzyme) of pH 1.2. The formulations were also studied for their polymorphic nature. Differential scanning calorimetry (DSC) and hot-stage microscopy were used to assess the homogeneity of the formulations and to detect if …
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Monitoring Dissolution of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy
… 7.4, 0.05M phosphate buffer pH 4.5 and simulated gastric fluid pH 1.2 as the medium. The percent dissolved was calculated for each brand and times vary depending on the pH level. All three brands dissolved one hundred percent in an eight hour period. A kinetic study was completed for each brand at …
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Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties
… PEC particles showed no release in simulated gastric fluid and rapid release in simulated intestinal fluid. Further evaluation studies should focus on the expected mucoadhesive and permeability-enhancing properties of chitosan–cellulose nanocrystal PEC particles.
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Development of an Ingestible Fluid Wicking Gastric Electrical Stimulation Platform for Hormone Modulation
… of the mucosal layer remains challenging due to gastric fluid that can disrupt targeted stimulation. In this work we first elucidate and establish the relationship between gastric electrical stimulation (GES) and the production of ghrelin, a hormone associated with hunger, in a pig model. Next, …
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High throughput analysis to study emerging pollutants and nanoparticle fate in biological systems
… contaminants in crop plant and simulated gastric fluid (SGF). Three types of mass spectrometry based methodologies have been developed, one is freeze-thaw/centrifugation extraction followed by high performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS) method for …
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Extraction methods for assessing the bioaccessibility of potentially toxic elements in urban airborne particulate matter by inductively coupled plasma mass spectrometry
… except for Cr.Finally, a new artificial mucus fluid was applied sequentially with the SBET and UBMSG (gastric fluid only) to measure bioaccessible PTE in inhaled PM10. Bioaccessible PTE concentrations, which were underestimated for As, Cr, Cu, and Pb, and overestimated for Cd, Fe, Ni and Zn …
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Influence of Compressible Aerogel Electrodes on the Properties of an Electrochemical Cell
… the electrode surface area in contact with the fluid was responsible for the effect. Optical micrographs were taken as a bubble along the electrode was pressurized. Using image analysis, the relationship of the change in surface area of the bubble correlated to the relationship of the change in …
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Spore-forming bacteria as pharmaceutical factories
… to lyse in presence of intestinal, though not gastric fluid, may have use in oral delivery. Cry1Ac of B. thuringiensis offers an alternative; large protein crystals are produced during sporulation. Here, various fluorescent fusions that maintain fluorescence over months were developed and …
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Studies investigating the preparation of solid core drug delivery systems for oral delivery of y-globulin via supercritical fluid processing technology
… release. Furthermore, supercritical fluid technology (SCFT) as a processing technique may be explored to ensure that the integrity of immobilized molecules is not compromised during the formulation process. The aim of this research was to develop a SCDDS for the oral delivery of …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… and physicochemical properties of bodily fluids and hydrodynamics at the specific site of drug administration. This PhD project aimed to advance the development of biorelevant in vitro testing strategies for complex drug delivery systems intended for parenteral administration, as well as …
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Improved functional properties and health benefits of whey protein by interaction with polysaccharides
… capacity. In the second section, in vitro gastric behavior of whey protein/polysaccharide mixed system was investigated, and its potential in promoting satiety and control blood glucose was discussed. Various polysaccharides were chosen to form heated complexes with whey protein at …
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Intragastric gelation of mixed soy protein isolate and alginate as well as its effect on postprandial glucose response and satiety
… of alginate on sucrose release and in vitro gastric digestion of soy protein isolate (SPI) in model beverages as well as to determine whether consumption of the model beverages would affect postprandial blood glucose response and appetite in healthy adults. Model beverages containing 5% w/v …
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Addressing and Assessing Lead Threats in Drinking Water: Non-Leaded Brass, Product Testing, Particulate Lead Occurrence and Effects of the Chloride to Sulfate Mass Ratio on Corrosion
… protocol. Unfortunately, tests with simulated gastric fluid revealed that much of this particulate lead would be bioavailable in the presence of chloride, warmer temperatures and lower pH inside the human stomach. It is recommended that water utilities be alert to this possible problem and that …
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Supramolecular hydrogels based on 1,3,5‐benzene tricarboxamides
… phosphate buffered saline (PBS), simulated body fluid (SBF), fasted state simulated gastric fluid (SGF), and fasted state simulated intestinal fluid (SIF). Most interestingly were the studies using SGF and SIF as these allow for conclusions regarding the oral administration of the gel system. The …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
… and pro-Pheroid®-goserelin in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The characteristics of Pheroid® revealed no change after the addition of goserelin to pro-Pheroid®. The stability study was non-conclusive due to loss of sample during centrifugation of the …
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Multimodal investigation of molecular mechanisms underlying gastrointestinal health and disease in horses
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01