Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"gap junctions"”.
-
Roles of gap junctions in neuronal networks
This dissertation studies the roles of gap junctions in the dynamics of neuronal networks in three distinct problems. First, we study the circumstances under which a network of excitable cells coupled by gap junctions exhibits sustained activity. We investigate how network connectivity and …
-
Potential involvement of gap junctions in pathology of addiction
… which seem occur only in addicted individuals. Gap junctions (GJs) allow cellular communication, indeed they are fundamental to regulate cellular synchronization, cellular growth and metabolic coordination in tissues. We analyzed the role of GJs proteins in the cocaine s mechanism of action and …
-
Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions
Connexine formen gap junctions, die den Transfer von Ionen, Metaboliten und second messengers zwischen sich berührenden Zellen vermitteln. An vielen Funktionen der Connexine, z.B. zellulärer Transport, Plaquebildung und -stabilität sowie Kanalleitfähigkeit sind Proteine beteiligt, die an die …
-
The Role of Gap Junctions in Congenital Diseases of the Heart
<p><strong>Background.</strong> Gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell …
-
Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions
… glattten Muskelzellen der Blutgefäße sind über Gap Junctions gekoppelt, auch eine myoendotheliale Kopplung wird diskutiert. Dadurch können Signale in Form von Ionen (und damit Änderungen des Membranpotentials) oder kleinen Moleküle über solche interzellulären Kanäle entlang der …
-
In vivo physiology of gap junctions between supporting cells in the organ of Corti
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
-
Excitable fibroblasts! : ion channels, gap junctions, action potentials and calcium oscillations in normal rat kidney fibroblasts
Contains fulltext : 19366.pdf (Publisher’s version ) (Open Access)
-
The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva
… was extended compared to Cx43, and that Cx31 gap junctions persisted longer at the cell surface. In REKs, Cx31 gap junctions were dynamic and the ablation of Cx43 did not prevent Cx31 gap junction formation. Furthermore, Cx31 and Cx30 localized to the same gap junctions and exhibited the …
-
Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
Gap junctions are responsible for providing and maintaining a pathway for intercellular communication. This is critical in the heart where gap junctions are responsible for maintaining electrical impulse propagation. Connexin43 (Cx43) is the most abundant gap junction in the heart, and studies have …
-
Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… many have explored how vascular processes alter gap junction communication and composition few have analyzed the role of specific gap junction connexin proteins in regulating cellular communication and wound healing. Using RNA interference or peptide inhibitors to downregulate specific connexins …
-
Messung der Zell-Zell Kopplung in Kolonkryptzellen der Ratte
… Zellen exokriner Drüsen durch die Kopplung über gap junctions als funktionelles Synzytium arbeiten. Auch die Kolonkrypte hat Eigenschaften, die denen der exokrinen Drüsen sehr stark ähneln. Die Zellen der Kryptbasis entsprechen einem Drüsenazinus, die Zellen der Kryptmitte und -oberfläche einem …
-
Alternative mechanisms of translation initiation in modulation of gap junctional coupling
Gap junctions, comprised of connexin proteins, are essential for direct intercellular electrical, metabolic, and immunological coupling. Connexin43 (Cx43, gene name GJA1) is the most ubiquitously expressed gap junction protein, and Cx43 gap junctions are altered in pathological states including …
-
The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
… relationship between connexin-containing gap junctions, cadherins, and integrins in cell communication and the ability of cells to respond to mechanical stimulation. The specific aim of this project was to determine the role of connexin containing gap junctions and confined compression on …
-
Investigating viral subversion of intercellular communication
… acute respiratory disease and viral myocarditis. Gap junctions, which are formed by connexin proteins, directly couple the cytoplasms of apposed cells enabling immunological, metabolic, and electrical intercellular communication. The gap junction protein connexin43 (Cx43; gene name – GJA1) is the …
-
Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
Gap junctions between neurons form the structural substrate for electrical synapses. Connexin 36 (Cx36, and its non-mammalian ortholog connexin 35) is the major neuronal gap junction protein in the central nervous system (CNS), and contributes to several important neuronal functions including …
-
Regulation of ageing by electrical synapses in the Nematode Caenorhabditis elegans
Electrical synapses formed by gap junctions are abundant in nervous systems and critical for brain function. They allow not only the exchange of ions, but also of metabolites and second messengers and have been implicated in the transmission of damage or death signals between cells. However, it was …
-
The Role of Connexin36 in Dopamine D1/D2 Synergism and its Breakdown in Transgenic Mice
… we have suggested that electrotonic coupling via gap junctions plays an important role in this phenomenon. A major constituent of gap junctions is connexin36 (Cx36), a protein that is abundant in neurons. The role Cx36 in D1/D2 synergism, as manifested behaviorally, was studied here in mice …
-
DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… the importance of mitochondrial energy supply, gap junctions, intercellular channels which connect plasma membrane of adjacent cardiomyocytes, by propagating action potential throughout the myocardium maintain cardiac synchronous beating and rhythm. Gap junctions have a rapid turnover and impair …
-
Two-Color Fluorescent Analysis of Connexin 36 Turnover and Trafficking – Relationship to Functional Plasticity
<p>Gap junctions (GJ) formed of Cx36 show tremendous functional plasticity on several time scales. Changes in connexin phosphorylation modify coupling in minutes through an order of magnitude, but recent studies also imply involvement of connexin turnover in regulating cell-cell communication. We …
-
The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
… membranes along microtubules finally forming a gap junction between cells. In the inner ear, gap junctions play a critical role in the generation the endocochlear potential, which is required for normal hearing. The aim of this study was to determine the role of gap junctions and their …
Page 1 of 4