Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 81 for “"gap junction"”.
-
Phosphorylation kinetics of cardiac gap junction regulation during stress
… of action potential between the cardiomyocytes. Gap junctions consisting primarily of connexin43 (Cx43) connect cardiomyocytes at regions of contact between cells known as the intercalated disc to facilitate cellular coupling. Cardiac pathologies frequently manifest with disrupted gap junctional …
-
Identification of a gap junction communication pathway critical in innate immunity
… this thesis describes identification of a gap junction intercellular communication pathway for amplifying immune and inflammatory responses, and demonstrates its importance in host innate immunity. The first section describes development of stable GFP reporters to study the spatiotemporal …
-
Gatekeeper Connexin43 Phosphorylation Events Regulate Cardiac Gap Junction Coupling During Stress
… the myocardium is essential to each heartbeat. Gap junctions comprising primarily Cx43 reside within the intercalated discs connecting cardiomyocytes, effecting not only direct intercellular electrical coupling, but the localization of other junctional structures and ion channels. Alterations in …
-
Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… many have explored how vascular processes alter gap junction communication and composition few have analyzed the role of specific gap junction connexin proteins in regulating cellular communication and wound healing. Using RNA interference or peptide inhibitors to downregulate specific connexins …
-
Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance
Gap junction channels (GJs) are oligomers of connexins forming channels linking neighbouring cells. GJs formed by different connexins show distinct unitary channel conductance (γj), transjunctional-voltage dependent gating (Vj-gating) properties, and magnesium modulation. We investigate here how …
-
Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling
… and mice that were heterozygous null for the gap junction (GJ) forming protein, Connexin 43. While the results of the comparison study showed differing extracellular ionic concentrations of the perfusates, specifically sodium, potassium, and calcium ([Na+]o, [K+]o, and [Ca2+]o), there was a …
-
Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… of CGRP, and neuron-glia interactions through gap junctions in trigeminal ganglion are implicated in the pathology of migraine and allergic rhinosinusitis. The goal of this study was to determine whether administration of 100% CO2 to the nasal mucosa of rats inhibits trigeminal ganglion …
-
Alternative mechanisms of translation initiation in modulation of gap junctional coupling
Gap junctions, comprised of connexin proteins, are essential for direct intercellular electrical, metabolic, and immunological coupling. Connexin43 (Cx43, gene name GJA1) is the most ubiquitously expressed gap junction protein, and Cx43 gap junctions are altered in pathological states including …
-
Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… levels leading to dissolution of cell-cell junctions, loss of apical-basal polarity, and cytoskeleton reorganization. Transforming Growth Factor-β (TGF-β) is well-established in driving cancer progression through EMT induction. Remodeling of cellular junctions, including gap junctions, is …
-
Investigating viral subversion of intercellular communication
… acute respiratory disease and viral myocarditis. Gap junctions, which are formed by connexin proteins, directly couple the cytoplasms of apposed cells enabling immunological, metabolic, and electrical intercellular communication. The gap junction protein connexin43 (Cx43; gene name – GJA1) is the …
-
Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
… and surrounding satellite glial cells via gap junctions in the trigeminal ganglion (TG). The goal of this study was to identify the gap junction proteins, or connexins (Cxs), in the ganglion in response to three different models of inflammation: acute, acute-sensitization, and chronic. …
-
DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… the importance of mitochondrial energy supply, gap junctions, intercellular channels which connect plasma membrane of adjacent cardiomyocytes, by propagating action potential throughout the myocardium maintain cardiac synchronous beating and rhythm. Gap junctions have a rapid turnover and impair …
-
Expression und Lokalisation von Pannexinen und Connexinen in der äußeren Retina der Maus
Es wurde gezeigt, dass Gap-Junction-Kanäle zwischen Stäbchen und Zapfen auf der Zapfenseite, jedoch nicht auf der Stäbchenseite aus Connexin36-Proteinen bestehen. Obwohl die verwendeten Methoden sensitiv genug waren, um geringe Connexin-Expression nachweisen zu können, konnte keines der bekannten …
-
Arrhythmogenic mechanisms of acute cardiac infection
… the heart are propagated by cardiomyocytes, via gap junctions, ion channels, and intracellular junctions, creating the healthy heartbeat. Cx43, the primary gap junction protein in the myocardium, not only propagates electrical signals, but also anti-viral molecules. Viral targeting of gap …
-
Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
… affects the electrical conductance in the atria. Gap junction channels, composed of connexin (Cx) proteins, allow the electrical signal to propagate between cardiac myocytes. Mutations in two highly expressed cardiac connexin genes, GJA1 (Cx43) and GJA5 (Cx40), have been identified by our group in …
-
The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva
… was extended compared to Cx43, and that Cx31 gap junctions persisted longer at the cell surface. In REKs, Cx31 gap junctions were dynamic and the ablation of Cx43 did not prevent Cx31 gap junction formation. Furthermore, Cx31 and Cx30 localized to the same gap junctions and exhibited the …
-
Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
Gap junctions are responsible for providing and maintaining a pathway for intercellular communication. This is critical in the heart where gap junctions are responsible for maintaining electrical impulse propagation. Connexin43 (Cx43) is the most abundant gap junction in the heart, and studies have …
-
Lycopene, Selenium, Vitamin E and Prostate Cancer
… mechanism of action, is that lycopene increases gap junction communication by increasing connexin 43 (Cx43) levels. To better characterize this mechanism, we utilized Cx43 +/+ and Cx43 -/- mouse embryonic fibroblasts (MEF) and two different treatment schedules (72-hour and 24-hour lycopene …
Page 1 of 5