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Showing 1 to 20 of 40 for “"gangliosides"”.
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Genetic and Biochemical Analysis of Mouse Brain Gangliosides
Made available in DSpace on 2014-12-14T15:38:02Z (GMT). No. of bitstreams: 1 7709181.pdf: 4094753 bytes, checksum: 1df22f7b85743239dccb45e91e590e98 (MD5) Previous issue date: 1976
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The role of complex gangliosides in glial cell biology
Gangliosides are a family of sialic acid-containing glycosphingolipids that are enriched in the nervous system. They are located in the outer leaflet of the plasma membrane within lipid rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… lipid class of the cell’s plasma membrane called gangliosides. These glycosphingolipid species have been shown to play various roles in the maintenance of neuronal viability. The purpose of this study is to use electrospray ionization mass spectrometry (ESI-MS) technique and immunohistochemistry …
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Characterization of Gangliosides and Fatty Acids in Extracellular Vesicles from Human Milk
… vivo</em> have not been characterized entirely. Gangliosides and fatty acids are integral in the formation, release, stability, and functionalities of EVs. Presumably, EV function is related to EV composition and lipids in EVs influence the bioavailability of EV cargo and downstream functions of …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… (IFN-gamma). We previously reported that gangliosides, membrane components of brain cells, especially neurons, can activate brain glial cells in vitro, thus could play roles in brain physiology and pathology. In this study, I tested whether gangliosides could induce the expression of …
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Development of a high-throughput shotgun-mass spectrometry method for qualitative and quantitative analysis of major mammalian brain gangliosides
… C18:1 + Fatty Acid C17:0) to quantify natural gangliosides. Ideally, we would need to have a fitting modified C17-ganglioside standard for each class to be quantified. Since first only GM1 as a modified standard was available, it was necessary to determine response factors (RFs) for the …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… xi I. INTRODUCTION 1 A. Brain inflammation 1 B. Gangliosides and oxidized low density lipoprotein (oxLDL) 2 1. Gangliosides 2 2. OxLDL 3 C. Inflammatory signaling pathways 7 1. JAK-STAT pathway 7 2. Lipopolysaccharide (LPS) –induced signaling pathways 8 3. Liver X receptor (LXR) pathway as …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… cells, curcumin effectively suppressed the gangliosides-, LPS-, or IFN-γ-stimulated induction of COX-2 and iNOS, important enzymes that mediate inflammatory processes. Also, curcumin consistently suppressed nuclear factor binding to GAS/ISRE sequences which regulate iNOS and COX-2 …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
<p>Gangliosides are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the …
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The role of tubulin in ganglioside-induced ramifications in cultured rat brain microglia
… morphology to an activated, amoeboid shape. Gangliosides, despite their role as microglial activators, induce microglial ramifications. To identify the cytoskeletal components involved in microglial ramification, we stimulated cells with gangliosides in the absence or presence of cytoskeletal …
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Monosialylgangliosides from human meconium: characterization using specific anti-oligosaccharide antibodies
… were used to detect specific monosialylgangliosides from the lipid fraction of human meconium. Gangliosides of this fraction were detected after thin layer chromatography by immuno-staining with specific anti-oligosaccharide sera. The monosialylganglioside fraction of human meconium was …
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Correction of AB Variant GM2 Gangliosidoses Using AAV9 Viral Vector Gene Therapy in a Mouse Model
… and death before 4-years of age. GM2 gangliosides are normally degraded in a cell’s lysosomes through the action of three gene products, HEXA, HEXB, and GM2A. A defect in any one of these genes can result in a deficiency of Hexosaminidase A (HexA) enzyme activity, which then cannot …
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Identification and characterization of an enterocyte receptor for group A porcine rotavirus
… specifically block rotavirus binding. Enterocyte gangliosides were harvested from susceptible piglets and a polar lipid fraction was isolated by solvent extraction and partitioning. Throughout subsequent purification of this fraction by Sephadex partition, ion exchange, silicic acid, and …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
… regulations of MMP-3 in LPS-, IFN？^-, and gangliosides-activated cultured astrocytes obtained from rat brain. MMP-3 transcript and protein were increased by stimulation with LPS, IFN？^ and gangliosides. Promoter analysis revealed that sequences between -500 to start codon are important in …
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… from presynaptic complex, and the other is gangliosides and anti-gangliosides antibodies. We found that snapin could increase current density of voltage-gated calcium channels in an isoform- and splice-variant-selective manner. Notably, the CaV2.1 and CaV2.2 channels are mutually exclusively …
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Axonal Transport of Glycoproteins and Glycolipids in the Goldfish Optic System
… radioactivity is found in highly purified gangliosides isolated from the tecta. Thus, gangliosides as well as glycoproteins are synthesized in the retinal ganglion cell body and then axonally transported. These experiments do not exclude the possibility that some incorporation of …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… to be altered in the presence of complex gangliosides. This project was initiated<br/> with an aim to examine the role of such cis-interactions between GD3 and other<br/> gangliosides such as GM1 in biological systems and thereby its impact on NK<br/> cell biology. B16 (78) cell line was …
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain Barré Syndrome
… antibodies were found to be specific to various gangliosides and ganglioside complexes. It was also found that antibody reactivity to gangliosides is affected by membrane components. The most prevalent (20-30%) immunoglobulin in GBS is anti-GM1 (20-30%), which also binds to the LPS of the PEN …
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Protein engineering of botulinum toxins with enhanced ganglioside binding capacity A biophysical and computational approach
… of the interaction of BoNT/A with gangliosides, using a combination of computational, biochemical, and biophysical methods. Specific achievements included: 1) The development and optimisation of two biophysical protocols for measuring Botulinum neurotoxin binding to gangliosides. 2) …
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Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
… europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, …
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