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Showing 1 to 2 of 2 for “"ganglioside GD3"”.
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… disialic acids such as present in the<br/> ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains immunoreceptor tyrosine based inhibitory<br/> motifs. It has been shown to inhibit NK cytotoxicity in cellular assays …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… studies revealed that OSW-1 suppressed Disialoganglioside 3 Synthase (GD3S) gene expression in melanoma cells, leading to inhibition of gangliosides GD3 and GD2. GD3 is an abundantly expressed melanoma cell surface antigen with pivotal roles in cancer progression and invasion. OSW-1 promoted …