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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"gamma secretase"”.

  1. Predicting Substrates of [gamma]-secretase in Drosophila/

    Wang, Yuhao, Ph.D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2016

    … method for predicting substrates of [gamma]-secretase in Drosophila and compared this method with other popular methods using some benchmark data set. Results show our method significantly outperforms other methods and generates important candidates for further experimental validation. …

    mit Repository record

  2. Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition

    Cummings, Matthew Aaron2016

    … autoimmunity. Small molecule inhibitors of γ-secretase (γSI) have been shown to suppress TH1 differentiation and reduce the severity of experimental autoimmune encephalomyelitis (EAE), presumably by affecting Notch signaling. To understand the mechanisms through which γSI alter autoimmune T …

    utswmed Repository record

  3. Intramembrane Proteolysis Mediated by the gamma-Secretase Complex : Nicastrin Functions as a Substrate Receptor

    Shah, Sanjiv2010

    … a growing list of cell signaling events. The gamma -secretase, one of a small family of independently evolved proteases, performs this enigmatic hydrolysis of a peptide bond within the membrane. Remarkably atypical, gamma-secretase activity: (1) requires a complex of proteins that include …

    utswmed Repository record

  4. The racial disparities of the Gamma-secretase/Notch pathway and inhibition in triple negative breast cancer

    Joseph, Jobin2024

    … to these disparities, with a specific focus on gamma secretase activity, a key regulator of cellular processes.</p> <p>The research methodology encompasses a multi-faceted approach, amalgamating clinical data analysis with extensive in vitro and in vivo experimentation. The study employs …

    cuny Repository record

  5. Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes

    Krishnaswamy, SudarsanEdith Cowan University, Research Online, Perth, Western Australia2010

    … multi-subunit enzyme complex is referred to as γ-secretase. The enzyme‟s ability to cleave a number of substrates has hampered the development of suitable inhibitors that target γ-secretase with the aim of specifically reducing Aβ production. A clearer understanding of the enzyme‟s structure and …

    edithcowan Repository record

  6. Analysis of gamma secretase regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems

    Nesic, IvaUniversität Heidelberg

    … the amyloid precursor protein (APP) by ?- and ?-secretase. APP is additionally processed through a non-amyloidogenic pathway by ?-secretase. Recent work suggests that amyloidogenesis is highly dependent on the levels of cholesterol within plasma membrane/early endosomes’ microdomains termed …

    heid-diss Repository record

  7. FKBP14 in Notch Signalling and Drosophila Development

    Bonner, Julia Maeve2014

    … proteins that form the catalytic core of the gamma-secretase complex, which cleaves a growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been closely linked to cases of early onset familial …

    toronto-retro Repository record

  8. Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration

    O'Donoghue, Jordan ChristopherUniversity College Cork2023

    … has been characterised as a substrate for gamma-secretase-mediated regulated intramembrane proteolysis (RIP). This proteolytic pathway begins with ectodomain shedding, mediated by sheddases, which produces a soluble fragment in the extracellular space. Following ectodomain shedding, a …

    cork Repository record

  9. The role of phospholipase D1 in trafficking and processing of amyloid precursor protein

    Point du Jour, Kimberly Shauntae2013

    … APP and presenilin 1, the catalytic subunit of gamma secretase. Here, we investigate the role of PLD1 in the biology of APP as well as in an AD mouse model. We report that removing PLD1, unlike PLD2, causes a dramatic decrease in brain levels of PA, indicating that PLD1 is a major source of PA …

    columbia-diss Repository record

  10. Amyloid precursor protein subtypes and secretases implicated in Alzheimer's disease.

    Boyce, Susan GillianSheffield Hallam University (United Kingdom).2011

    … APP[751]; APP[695]; ADAM 9, 10 and 17 as alpha-secretases; BACE 1 as beta-secretase and PS1 as gamma-secretase.The APP[695] isoform was found to have the highest levels in the frontal and temporal regions. However, the APP[751] isoform was found to be at the highest level, with very low levels …

    sheffield-hallam

  11. RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals

    Turkoz, Mustafa2014

    … root sheath cells. Ligand-dependent activation, gamma-secretase-dependent cleavage, and RBPjk-mediated downstream transcriptional activities of Notch receptors constitute the "canonical" Notch signaling pathway. This implies that loss of gamma-secretase (no Notch Intracellular Domain (NICD) …

    wustl Repository record

  12. DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy

    Bunston, Carly2021

    … pathway, which can be suppressed using gamma-secretase inhibitors such as dibenzazepine (DBZ). We investigated the effects of the Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) on tumour resistance to TMZ and GCSCs. Methods: U87 and U251 glioblastoma cells were transduced with …

    plymouth Repository record

  13. Identifying notch-regulated genes using a specific notch signaling inhibitor

    Gafar, Hammed

    … pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To address this limitation, this …

    eastern-wash Repository record

  14. Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance

    Melidosian, Bihui2020

    … is abrogated by combining radiation with gamma secretase inhibitors. Thus, stromal cells orchestrate an intricate crosstalk with BrCa cells by utilizing exosomes to instigate BrCa cell antiviral signaling. This expands BrCa subpopulations adept at resisting therapy and reinitiating tumor …

    penn Repository record

  15. The Contribution of APP gene dosage to the molecular phenotypes of Alzheimer's disease in human trisomy 21 neurons

    Momoh, AyibaUniversity of Cambridge2019

    … APP T719F; a form of APP resistant to gamma-secretase cleavage. In summary, having three copies of chromosome 21 is causal and fully penetrant for AD-related phenotypes in vitro. In trisomy 21 neurons, APP dosage contributed to the molecular phenotypes of Alzheimer’s disease and the …

    cambridge Repository record

  16. Role of Notch Signaling in T Cell Polarization

    Keerthivasan, Shilpa2016

    … We observed that Notch signaling inhibition by Gamma Secretase Inhibitors (GSI) in the EAE model ameliorates the symptoms as well as delays the onset of disease. We also observed a decrease in IL-17 and IFNγ cytokine expression levels among restimulated splenocytes and mononuclear cells of the …

    loyola-thes Repository record

  17. Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population

    Grudzien, Peter2016

    … self-renewal, and can be effectively blocked by gamma-secretase inhibitors (GSIs). While GSIs are currently in clinical trials for breast cancer, it is not fully understood how these compounds will affect CSCs or if CSCs from different breast cancer phenotypes will be differentially …

    loyola-thes Repository record

  18. Investigating β- and γ-secretase function and processing of APP with genetic and pharmacological tools

    Hallam, RyanBrock University2025

    … Amyloid Precursor Protein (APP) by BACE1 and the gamma secretase complex (γS) generates amyloid-beta (Aβ), a small peptide that is highly implicated in the pathogenesis of Alzheimer’s Disease. Despite decades of research, there remains a lack of understanding of the endogenous functions of APP, …

    brock Repository record

  19. Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy

    Clementz, Anthony George2016

    … the combined inhibition of Notch signaling via a gamma-secretase inhibitor (GSI) and knockdown of PEA3 (via siRNA) significantly growth arrested breast cancer cells in G1 and decreased both anchorage dependent and independent growth in vitro. In correlation, a significant decrease in cell …

    loyola-thes Repository record

  20. Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays

    Houlihan, William J2019

    <p>Gamma-Secretase (γ-secretase) is a transmembrane protease of increasing interest, which has been shown to have significant connections to both cancer and Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane …

    cuny Repository record

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