Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"gamma delta T cells"”.
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Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… is maintained by antigen-specific regulatory T cells (Tregs). ACAID regulates harmful immune responses that can lead to irreparable injury to innocent bystander cells that are incapable of regeneration. ACAID is a product of complex cellular interactions that involve F4/80+ ocular antigen …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
… and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via cytokines produced in response to microbial phosphoantigens. gamma delta T …
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T-Cell Treatments For Solid and Hematological Tumors
… and efficacy as cancer treatment modalities. T cells can be dichotomized by their T cell receptor (TCR) complexes where alpha/beta T cells (95% of T cells) and gamma/delta T cells (+T cells proliferated to clinically significant numbers and ROR1<sup>+</sup> tumor cells were effectively targeted …
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Mechanisms of generating T cell receptor diversity
T cells are able to respond to foreign antigens by means of a diverse repertoire of antigen-specific receptors (T cell receptors or TCRs). There are two classes of TCRs ($\alpha\beta$ and $\gamma\delta$) that are found on mutually exclusive populations of T cells. Diversity in each receptor subunit …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
… thesis, I focused my study on the role of Id2 in gamma delta T cells and CD4<super>+</super> alpha beta T cells, as well as the role of Id3 in B cells.</p><p> Id proteins have been shown to control gamma delta T cell development. Id3 knockout mice demonstrate a dramatic expansion of innate-like …
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Adoptively transferred maternal colostral cells impact immune status and development in dairy calves
… antibodies. Colostrum also contains proteins and cells, which may enhance immune development in the neonate. Our goals were to determine the impact of colostral immune cells on (1) immune status during the first month of life and (2) immune development over time. To determine the impact of …
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Evaluation of the microenvironment and immune function in histiocytic sarcoma, a tumour of dendritic cells
… has been a growing interest in regulatory T cells (Treg). This population of cells has the ability to down-regulate the immune system, aiding tumour growth and diffusion. In the literature evidence can be found of Treg infiltrating tumours and of elevation of percentages of Treg in peripheral …
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The Safety and Immunostimulatory Properties of Amorphous Silica Nanoparticles <10 nm in Diameter
… transformed and cancerous cell lines and primary cells. The particles were toxic to the immune cells in a dose dependent manner and impaired certain cellular functions. Primary cells were most susceptible to nanosilica induced death and, of the primary cells, phagocytes were most susceptible to …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… generation of a diverse repertoire of mature T cells from precursors derived from the bone marrow. In addition to conventional CD4 and CD8 T cells, innate-like T cells also develop in the thymus and share features of the adaptive and the innate immune system. These ‘unconventional’ T cells have …
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Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
… populations were determined. We focussed on NK cells and gamma-delta-TCR positive T cells as both belong to the cellular immune response early post HIV/SIV-infection. In addition both populations can activate the adaptive immune response by cytokine secretion. To obtain NK cells and …