Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"gamma delta"”.
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SKIN COMMENSAL STAPHYLOCOCCUS PROMOTES SYSTEMIC V-GAMMA-6 GAMMA-DELTA T CELL RECONFIGURATION
The gut microbiota is known to regulate both local immune responses and systemic functions in healthy hosts. However, it remains unclear whether the skin microbiota – resident on the body's largest barrier – can influence systemic responses. Skin-resident Staphylococcus aureus is a common commensal …
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Untersuchungen zur Rolle von CD8 bei der Aktivierung von gamma-delta-T-Zellen der Ratte
CD8 wird von thymisch gereiften a/b T Zellen als CD8ab-Heterodimer exprimiert und dient als Korezeptor bei der MHC Klasse I (MHC I) restringierten Antigenerkennung. In dieser Funktion stabilisiert CD8 die Bindung des T Zellrezeptors (TCR) an seinen Liganden (MHC I mit antigenem Peptid) und …
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Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
… were determined. We focussed on NK cells and gamma-delta-TCR positive T cells as both belong to the cellular immune response early post HIV/SIV-infection. In addition both populations can activate the adaptive immune response by cytokine secretion. To obtain NK cells and gamma-delta-TCR …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
… in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via cytokines produced in response to microbial phosphoantigens. gamma delta T cells have also …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
Background: Both the innate and adaptive immune systems contribute to autoimmune injury in multiple sclerosis (MS). We have been particularly interested in elucidating the role of the innate γδ T-cell population in MS pathogenesis. In particular, some γδ T-cells that express Fc receptors (FcR), …
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Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… presenting cells (APC), NK T cells, B cells, gamma delta (gamma delta ) T cells, CD4+CD25+ Tregs, and CD8+ Tregs. Antigens injected into the AC are processed by F4/80+ antigen presenting cells (APC), which migrate to the thymus and spleen. In the spleen, ocular APC induce the development of …
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T-Cell Treatments For Solid and Hematological Tumors
… where alpha/beta T cells (95% of T cells) and gamma/delta T cells (+T cells proliferated to clinically significant numbers and ROR1<sup>+</sup> tumor cells were effectively targeted and killed by both ROR1-specific CAR<sup>+</sup> T cell populations, although ROR1RCD137 were superior to …
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Host cell signaling in response to RSV infection
… previous study has reported the existence of IKK gamma delta, a splicing variant of IKK gamma, which excludes exon 5. I compared the function of IKK gamma and IKK gamma delta in response to ssRNA viruses. I found that in contrast to IKK gamma, which is essential for both NF-kappa B and IRF3 …
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Enantioselective synthesis of alkenyl aziridine carboxylates and 4-phenylsulfenyl prolines
… been generated from aminosulfoxonium-substituted gamma,delta-unsaturated alpha-amino acids (method A) and 1-alkenyl aminosulfoxonium salts (method B) upon treatment with DBU. Their application to the asymmetric aziridination of N-tert-butyl-sulfonyl imino ester, generated either in situ (method A) …
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Struktur, Hydroxyalkylierung und Aminoalkylierung von Titanaallylsulfoximinen: Enantioselektive Synthese ungesättigter Alpha-Aminosäuren
… regio- und diastereoselective with aldehydes in gamma-position to yield delta- resp. beta-N-methylsulfonimidoyl-substituted homoallylic alcohols. This reaction and the structures of the titanium(IV)-complexes were examined in detail. Furthermore it was found, that these complexes reacted regio- …
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Mechanisms of generating T cell receptor diversity
… are two classes of TCRs ($\alpha\beta$ and $\gamma\delta$) that are found on mutually exclusive populations of T cells. Diversity in each receptor subunit ($\alpha,\ \beta,\ \gamma, or\ \delta$) is generated by several mechanisms with the key process being gene rearrangement. Sequence analysis …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
… thesis, I focused my study on the role of Id2 in gamma delta T cells and CD4<super>+</super> alpha beta T cells, as well as the role of Id3 in B cells.</p><p> Id proteins have been shown to control gamma delta T cell development. Id3 knockout mice demonstrate a dramatic expansion of innate-like …
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Female alcoholic subtypes : some clinical and social implications
… Subjects were assigned to one of three groups: Gamma, Delta and Intermediate as defined by Jellinek (1960) using Walton's criteria (1968) of Gamma/Delta alcoholism. It was hypothesized that there would be intergroup differences on all of the above measures. The Symptom Sign Inventory (SSI) was …
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Untersuchungen zur immunologische Rolle von HFE, einem HLA Klasse I homologen Gen, das bei der hereditären Hämochromatose Punktmutationen zeigt
… Chromium-Relelase-Assays <br>mit PBL, NK- und gamma/delta T-Zell-Klonen verschiedener Spender zeigten zudem einen <br>hemmenden oder aktivierenden Einfluß der HFE-Expression auf transfizierten Targetzellen <br>auf das Lyseverhalten von Gruppen dieser Effektorzellen. Diese Ergebnisse lassen den …
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Polycyclisation anionique : Progrès vers la synthèse de 14[bêta]-hydroxystéroïdes
… et un [bêta]-cétoester [gamma],[delta minuscule]-insaturé (réactif de Nazarov), pouvant mener directement à des produits au squelette tétracyclique de type stéroïdien. Les synthèses de nouveaux réactifs de Nazarov et cyclohexénones seront exposées, de même que les …
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Personality characteristics of wives of gamma and delta alcoholics
… husband's pattern of drinking, 17 falling into gamma and 23 into delta categories. Subjects were tested on Cattell 's 16PF, Fould1 s Hostility Questionnaire and Gough and Heilbrun's Adjective Check List. In addition, information as regards family background, drinking history and pattern of …
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Asymmetrische Synthese von bicyclischen Alpha-Aminosäuren durch intramolekulare Pauson-Khand-Reaktion von l-Alkenylsulfoximinen und Festphasensynthese mit Allylsulfoximinen
… with titanated allylic sulfoximines led to gamma,delta-unsaturated alpha-amino acid esters (de < 98%) in 67-85% yield. Propargylation at the amino nitrogen atom gave 5-Azaoct-1-en-7-ynes in 91-95% yield. Pauson-Khand Reaction of these Enynes with Co2(CO)8 activated by N-Morpholine-N-oxide …
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Adoptively transferred maternal colostral cells impact immune status and development in dairy calves
… gene expression and numbers of CD4+ and gamma delta T cells when compared to WC-fed calves. This study demonstrates that colostral immune cells impact immune status and development in dairy calves.
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies that do not require HLA-matching and have shown low toxicity in previous studies. In this project, we sought to evaluate FT538 induced pluripotent stem cell-derived …
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Effects of single nucleotide polymorphisms in leptin and pro-opiomelanocortin on peripheral eucocyte counts in beef cattle
… types of lymphocytes evaluated included B cells, gamma delta cells, regular and activated CD4 and CD8 cells and numbers of lymphocytes as well as baseline serum antibody titres. On day 21, antibody titres were measured and a booster vaccine was administered. Finally on day 42, antibody titres and …
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