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Showing 1 to 20 of 46 for “"gamma aminobutyric acid"”.
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Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
The hypothalamus is involved in energy balance, appetite regulation, stress and anxiety, reproduction including sex behavior, and aggression. It is divided into cell groups based on cell staining, functional similarities and projections. This dissertation looks at the development of three of these …
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The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics
Gamma-aminobutyric acid (GABA) has been shown to be an important inhibitory neurotransmitter in mammalian central nervous system (CNS). GABA receptors have been previously characterized in mammalian brain using 3H-GABA itself, a potent GABA agonist, 3H-muscimol, and the GABA antagonist, …
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The synthesis and biochemical and pharmacological evaluation of gamma-aminobutyric acid antagonists
Y-Aminobutyrio acid has been shown to be a major inhibitory neurotransmitter in the central nervous system (CNS). This study is concemed with the examination of a number of GABA antagonists in two in vitro assay systems. A series of cage-structured compounds including bicyolic phosphate esters …
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The role of Gamma-aminobutyric acid and Hydrogen peroxide in cell death in grape berry development
… in berries. Another metabolite of interest is Gamma-aminobutyric acid (GABA) which might have a role in cell death in berries because the concentration of H2O2 and GABA in cells tends to increase under stress. Chapter 1 analyses the literature on H2O2, and GABA, a four-carbon non-protein amino …
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Temporal Changes in the Levels of Gamma-Aminobutyric Acid in the Brain of the Cockroach, Leucophaea Maderae
… the biological clock, and it has been shown that gamma-aminobutyric acid (GABA) plays an important role in the vertebrate circadian system. The importance of GABA in the vertebrate SCN and its presence in the brain of the cockroach made the inhibitory neurotransmitter GABA a prime candidate for …
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Glutamic Acid Decarboxylase and the Gamma-Aminobutyric Acid Pathway in the Supraesophageal Ganglion of the Honeybee, Apis Mellifera (Hymenoptera, Apidae)
Made available in DSpace on 2014-12-11T18:05:31Z (GMT). No. of bitstreams: 1 7105098.pdf: 3708700 bytes, checksum: fe7964e6cd4b948a191c97559688f42f (MD5) Previous issue date: 1970
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ΣΥΜΒΟΛΗ ΣΤΗΝ ΕΡΜΗΝΕΙΑ ΤΗΣ ΝΕΥΡΟΓΕΝΟΥΣ ΡΥΘΜΙΣΗΣ ΤΗΣ ΕΓΚΕΦΑΛΙΚΗΣ ΚΥΚΛΟΦΟΡΙΑΣ
TO TEST THE HYPOTHESIZED ROLE OF GAMMA-AMINOBUTYRIC ACID (GABA) ON THE CEREBRAL CIRCULATION, WE USED A PRESSURE MICRO-INJECTION SYSTEM TO SIMULTANEOUSLY ADMINISTER VARIOUS CONCENTRATIONS OF GABA AND MEASURE THE TISSUE PO22 USING AN ADJACENT PO2 MICROELECTRODE. GABA INJECTED DIRECTLY INTO THE …
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CHEMICAL INDUCTION OF SETTLEMENT IN LARVAE OF THE EASTERN OYSTER <italic>CRASSOSTREA VIRGINICA </italic> (GMELIN)
… salinity of 9.6 (±0.1). The compounds γ-aminobutyric acid and acetylcholine chloride, both at 10<super>-4</super>M, did not significantly increase the percentage of larvae exhibiting settlement behavior. As compared with the control, a significant increase in settlement behavior …
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The Localization of GABA-Like Immunoreactivity in the Optic Lobe Neuropils and Optic Tracts of the Cockroach Leucophaea Maderae
Gamma aminobutyric acid (GABA) is a prominent neurotransmitter found in both vertebrates and invertebrates. The action of GABA has been accepted to be inhibitory in nature, but recent evidence suggests it is both inhibitory and excitatory, depending upon time of day. The amount of GABA measured in …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
… enhanced the toxicity of insecticides targeting gamma-aminobutyric acid (GABA)-gated chloride channels, indicating the potential of insect mAChRs as a target for developing novel insecticides/synergists to control resistant pests. A point mutation (A301S) in the GABA-gated chloride channel …
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Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping
… they induce sleep by binding to the same gamma-aminobutyric acid (GABA) receptors in the central nervous system. They may be less likely than benzodiazepine medications to disrupt natural sleep rhythm and patterns which may make sleep more restful. Ramelteon (Rozerem) is a new category of …
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Alternating Current Stimulation for Essential Tremor
… dysfunction of the inhibitory neurotransmitter gamma-aminobutyric acid. Current treatments for essential tremor are largely unappealing to patients due to either being invasive (surgical), ineffective, and/or causing severe side effects. Previous studies on the impact of ACS in tremor are …
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Systemic administration of putrescine induces GABA-like behaviors in rats
… precursor of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Conversion of systemically administered putrescine to GABA in rat neural tissues has been reported. In this thesis, three experiments were conducted to characterize changes in rat behavior after putrescine …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… as phenobarbital, display poor efficacy rates. Gamma-aminobutyric acid (GABA)-mediated signalling may promote excitatory neurotransmission in neonates with a birth injury due to intracellular accumulation of chloride. Bumetanide is a potential adjunct treatment for neonatal seizures, which …
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A Structural and Computational Study of GABAA Receptor Diversity
… in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a pool of 19 paralogous genes, each conferring the receptor unique properties, such as ligand binding, gating …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
<p>Gamma aminobutyric acid (GABA) is an inhibitory neurotransmitter, produced by neurons in the central nervous system (CNS) and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that …
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Effects of GABA on inflammation and intestinal barrier disruption
… microbiota composition, reducing frequencies of gamma-aminobutyric acid (GABA)-producing bacteria. GABA levels are reduced in the brains and circulation of MS patients. We engineered Lactococcus lactis with extra copies of gadB (glutamic acid decarboxylase) and gadC (glutamate/GABA antiporter) to …
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… We found that alcohol increased gamma-aminobutyric acid (GABA) release via HSF1, but had no effect on glutamatergic synaptic vesicle fusion. Collectively, these data indicate that alcohol induction of HSF1 transcriptional activity triggers a specific coordinated adaptation in …
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… D3R-/- mice show a 15-fold higher expression of gamma-aminobutyric acid receptor A (GABAA) alpha6 subunit in striatum compared to their WT littermates (Leggio et al., 2015). Based on previous data present in literature, the main hypothesis of my research project has been that the D3R, showing a …
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Urbanization affects environmental conditions for developing songbirds
… if there were any differences in nestling amino acid profiles or body condition between habitat types. Prior work found that urban habitats also have far higher rates of brood parasitism, which can additionally restrict food intake for urban nestlings. However, this prior work has also found that …
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