Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"gametocytogenesis"”.
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… requirements of malaria parasites during gametocytogenesis, as well as during the mosquito stages, are urgently needed to reveal novel targets for development of transmission-blocking agents. Furthermore, increasing drug resistance of the parasites to current antimalarials, including …
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Enabling the in vitro study of long noncoding RNAs to understand their role in Plasmodium falciparum
… assessing changes in fitness, drug resistance, gametocytogenesis and expression. I identified potential roles for specific lncRNAs in drug resistance and gametocytogenesis. By developing bioinformatics and molecular tools, this work enables future studies elucidating the specific roles of …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… to an essential differentiation stage, gametocytogenesis, in P. falciparum. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), which results in selective translation of mRNAs encoding stress response …
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Characterisation of Plasmodium parasite sexual commitment and development
… gain an opportunity to transfer to a new host. Gametocytogenesis, the formation of these sexual forms, is therefore essential for malaria transmission, and an attractive target for transmission blocking interventions. Despite its importance, we know little about sex-specific gene expression or …
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Investigating the ubiquitin conjugating machinery in *Plasmodium falciparum*
… involved in DNA replication and gametocytogenesis. The utilisation of data-independent acquisition (DIA) mass spectrometry generated the largest Plasmodium ubiquitome to date. These findings contribute to a deeper understanding of the ubiquitin pathway in *P.falciparum* and …
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
… the identification of novel essential genes in gametocytogenesis and a greater understanding of the genes expressed during this developmental process which will be important in developing novel transmission-blocking strategies. I then developed and applied a scRNA-seq preservation protocol in …
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Using Single-Cell Analyses to Uncover Transcriptional Heterogeneity in Plasmodium falciparum
… markers that are expressed as early as stage III gametocytogenesis, providing further insight into Plasmodium sex-specific differentiation previously masked in population analyses.</p><p>The second part of this work centered on single-cell RNA sequencing (scRNA-seq) of P. falciparum late asexual …