Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"galectin-8"”.
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Effects of galectins and antibodies in HIV infection; Novel Assays
… via host glycan-binding protein, such as galectins. To explore this, we examined the interaction of gp120 (the surface Env protein) with a panel of galectins, by adapting the fluorescent anisotropy (FA) assay to microscale. Galectin-8, a galectin with two carbohydrate recognition domains …
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Sphingomyelin as a danger signal in cell-autonomous immunity
… are detected by the cytosolic danger receptor, Galectin 8. My research reveals that sphingomyelin, a host lipid predominantly located on the outer leaflet of the plasma membrane, is exposed to the cytosol on damaged BCVs. I visualised the appearance of intracellular sphingomyelin by utilising …
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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. …
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
… lytic protein VI. Using the cytosolic protein galectin-3 (gal3) as a marker of membrane rupture, we demonstrate that Ad5 membrane rupture occurs at or near the cell surface upon exposure of protein VI. However, translocation of the virus across ruptured membranes occurs more frequently from …
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Engineered approaches to querying the microenvironment of cancer metastasis
… of ECM composed of fibronectin with any of galectin-3, galectin-8, or laminin. In the next part of this thesis, these molecules are investigated for their involvement in mice bearing the autochthonous tumors or in humans with lung cancer. The integrin Q3p1 is found to mediate adhesion to the …