Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"galectin-1"”.
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Molecular Analysis of the Unconventional Export Machinery of Galectin-1, a beta-Galactoside-specific Lectin of the Extracellular Matrix
Galectin-1 ist ein β-Galaktosid-spezifisches Lektin der extrazellulären Matrix, das an der Regulation verschiedener zellulärer Prozesse wie Zellproliferation, Differenzierung und Apoptose beteiligt ist. Das extrazelluläre Auftreten von Galectin-1 war zunächst eine überraschende Entdeckung, da das …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… immune system. The second part, I showed that galectin-3 exerts cytokine-like regulatory actions in rat and mouse brain-resident immune cells. Expression and secretion of galectin-3 were significantly enhanced in glia under IFN--stimulated, inflamed conditions. After exposure to galectin-3, …
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Study of Glycan-Mediated Interactions by Photocrosslinking GlcNAc and GalNAc Analogs
… binding partners of two glycan binding proteins, galectin-1 and cholera toxin B subunit. In addition, I will demonstrate the preliminary results I have on GalNDAz incorporation and photocrosslinking, which indicate that GalNDAz may be incorporated into cellular glycans. Chapter 1 introduces the …
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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… cells. Mass spectrometry data identified galectin family members in the glioblastoma secretome. ELISA assays confirmed galectin presence in GBM-derived liquid samples; immunofluorescence confirmed their presence in tumour sections, as well as the presence of T-cells, B-cells and …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… that out of 59 glioblastoma samples, 58 showed Galectin-1 as commonly secreted protein and galectin-1 was accumulated near T cells which were present around the blood vessels in glioblastoma samples. The galectin-1 secretion was regulated by IFN-ϒ, which might be from activated T cells. Along …
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Functional properties of galectin-3. Beyond the sugar binding.
… activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 roles in differently activated …
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Analisi Molecolare del Melanoma
… cell lines as compared with melanocytes: galectin-1, inosine-5'-monophosphate dehydrogenase 2, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these …
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Proteomische Analyse des Nierenzellkarzinoms: Identifizierung von potentiellen Biomarkern
… ergab, dass neben anderen Proteinen vor allem Galectin-1 beim Nierentumor verstärkt exprimiert wird. Durch das genaue Wissen über die Veränderungen auf Proteomebene, die sich beim NZK abspielen, könnte eine individuelle Diagnostik, Bewertung der Prognose sowie Therapie für jeden einzelnen …
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Identification of altered Ras signaling and intermediate filament hyperphosphorylation in giant axonal neuropathy
… results in significantly elevated levels of the galectin-1 (Gal-1) protein. Gal-1 stabilizes the active form of the Ras signaling protein, which functions as a molecular switch to regulate the phosphorylation and subsequent organization of IFs. The connection between these pathways led us to …
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Metabolic Pathways for Natural and Unnatural Sialic Acids
… in the branch structure of N-glycans and impairs galectin-1 binding to cells. Furthermore, I found that sialylation of N-glycans can further influence N-glycan branching. Taken together, my work suggests unexplored mechanisms for hIBM pathogenesis. The use of unnatural sialic acids, such as …
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Regulation of Ras signaling and oncogenesis by plasma membrane microdomains
… and retention of H-Ras at these sites requires Galectin-1 (Gal-1). We have previously found that genetically-mediated Lo sequestration of H-Ras inhibited MAPK signaling but not PI3K activation. Here we show that inhibition of Gal-1 with OTX008 sequestered H-Ras in the Lo domain, blocked …
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The role of B cells in the amplification and in the regulation of transplant rejection.
… ii) to analyse whether the<br/>expression of Galectin-1 (Gal-1), known to be a functional molecule for Tregs, is<br/>necessary for T2-MZP to suppress; iii) to study whether an increase in T2-MZP<br/>is observed in tolerant mice like what has been shown in tolerant …
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Molecular Analysis of the Unconventional Export Machinery of HASPB, a component of the surface coat of Leishmania parasites
… the angiogenic growth factor FGF-2 and Galectin-1, a lectin of the extracellular matrix, proteins secreted by unconventional means, were shown to be secreted normally from the HASPB export mutant cell line. These observations demonstrate that the export machinery component defective in …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… via host glycan-binding protein, such as galectins. To explore this, we examined the interaction of gp120 (the surface Env protein) with a panel of galectins, by adapting the fluorescent anisotropy (FA) assay to microscale. Galectin-8, a galectin with two carbohydrate recognition domains …