Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"galectin"”.
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… of a family of immunomodulatory proteins (galectins) in fibroblasts from rhematoid arthritis patients. Synovial fibroblasts were found to differ significantly from bone marrow and skin fibroblasts with higher expression of galectin-9 and galectin-12 in synovial fibroblasts. Galectin-9 and …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… cells. Mass spectrometry data identified galectin family members in the glioblastoma secretome. ELISA assays confirmed galectin presence in GBM-derived liquid samples; immunofluorescence confirmed their presence in tumour sections, as well as the presence of T-cells, B-cells and …
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Functional properties of galectin-3. Beyond the sugar binding.
… activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 roles in differently activated …
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Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
… specimens and cell lines, the over expression of galectin-3 is associated with disease progression and metastatic potential. Herein, we have sought out to determine whether galectin-3 affects the malignant melanoma phenotype by regulating downstream target genes. To that end, galectin-3 was stably …
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Investigation of conventional and unconventional protein secretion using galectin-3
… surrounding the regulation of protein secretion. Galectin-3, an unconventionally secreted protein, was used here to investigate both conventional and unconventional protein secretion. The unconventional protein secretion of galectin-3 is poorly understood. To address this, genetic manipulation of …
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The role of Galectin-3 in the pathogenesis of Parkinson's Disease
… Recientemente se ha relacionado a la proteína Galectina-3 (Gal3) con los Cuerpos de Lewy en cerebros post-mortem. Gal3 es una proteína de unión a galactósidos sin actividad catalítica y expresada principalmente por células de la microglía, las células inmunes del sistema nervioso central, en …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… leaflet of the membrane to the host cytosol. Galectins, cytosolic host glycan binding proteins, are then able to recognize the exposed sugars and bind them. Subsequently, host defense proteins including the guanylate binding proteins (GBPs) are recruited to the damaged membrane. I propose that …
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FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS
Galectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now …
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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. …
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Molecular Analysis of the Unconventional Export Machinery of Galectin-1, a beta-Galactoside-specific Lectin of the Extracellular Matrix
Galectin-1 ist ein β-Galaktosid-spezifisches Lektin der extrazellulären Matrix, das an der Regulation verschiedener zellulärer Prozesse wie Zellproliferation, Differenzierung und Apoptose beteiligt ist. Das extrazelluläre Auftreten von Galectin-1 war zunächst eine überraschende Entdeckung, da das …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… immune system. The second part, I showed that galectin-3 exerts cytokine-like regulatory actions in rat and mouse brain-resident immune cells. Expression and secretion of galectin-3 were significantly enhanced in glia under IFN--stimulated, inflamed conditions. After exposure to galectin-3, …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… via host glycan-binding protein, such as galectins. To explore this, we examined the interaction of gp120 (the surface Env protein) with a panel of galectins, by adapting the fluorescent anisotropy (FA) assay to microscale. Galectin-8, a galectin with two carbohydrate recognition domains …
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Mechanistic Study of The Small Molecule Inhibitor DX-52-1
… with nanomolar concentration. We have identified galectin-3, a multifunctional protein whose best-known function is its sugar binding ability, as a secondary target of DX-52-1 with functions in cell motility. In addition, we have identified HUK-921, another small molecule with antimigratory …
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Identification of differentially expressed genes in breast cancer tissues and cells
… in nude mice; obtained by stable transfection of galectin-3 gene in a non-tumorigenic BT 549 breast cell line, was analyzed by differential display. Galectin-3, a calcium independent carbohydrate binding protein has been shown to be involved in many biological processes, but its exact function is …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… that out of 59 glioblastoma samples, 58 showed Galectin-1 as commonly secreted protein and galectin-1 was accumulated near T cells which were present around the blood vessels in glioblastoma samples. The galectin-1 secretion was regulated by IFN-ϒ, which might be from activated T cells. Along …
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Engineered approaches to querying the microenvironment of cancer metastasis
… of ECM composed of fibronectin with any of galectin-3, galectin-8, or laminin. In the next part of this thesis, these molecules are investigated for their involvement in mice bearing the autochthonous tumors or in humans with lung cancer. The integrin Q3p1 is found to mediate adhesion to the …
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Study of Glycan-Mediated Interactions by Photocrosslinking GlcNAc and GalNAc Analogs
… binding partners of two glycan binding proteins, galectin-1 and cholera toxin B subunit. In addition, I will demonstrate the preliminary results I have on GalNDAz incorporation and photocrosslinking, which indicate that GalNDAz may be incorporated into cellular glycans. Chapter 1 introduces the …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
… Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not been well explored. Considering the emerging role of mast cells in host defense, I studied the effect of various cytokines, a TLR agonist or …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
… probes. Chapter 2: β-Galactoside targeting of galectin-3 Galectins are a family of intra and extra-cellular proteins which bind specifically to the β-galactoside carbohydrate residues of cellular glycoproteins. Several galectins, but most significantly galectin-3, have been found to mediate …
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Structural analysis of cytokine signaling modulators
… modulate signal transduction by interacting with galectin-3 and generating a cell surface lattice. This opposes constitutive endocytosis and reduces the thresholds for cytokine signaling. The preferred ligands for galectin-3 are the poly-N-acetyl lactosaminylated tetra-antennary glycans which are …
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