Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"galactosylceramide"”.
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Regulation of Galactosylceramide Biosynthesis
… glycosylated to glucosylceramide (GlcCer) versus galactosylceramide (GalCer), which are precursors of all mammalian glycosphingolipids. Relatively few studies have focused on this branchpoint because these monohexosylceramides are somewhat difficult to resolve chromatographically and because …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… effectiveness of a synthetic glycolipid, alpha-Galactosylceramide (-GalCer), as an adjuvant for mucosal immunization with peptide and protein antigens, by oral and intranasal routes, to prime antigen-specific immune responses in multiple systemic and mucosal compartments. The adjuvant activity …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… immunity. The synthetic glycolipid alpha-Galactosylceramide (α-GalCer) effectively activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered antigens. …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T cells produce high quantities of T<sub>H</sub>1 and T<sub>H</sub>2 type cytokines, thus shape subsequent adaptive immunity towards inflammation …
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Characterisation of the immunomodulatory properties of human natural killer T cells
… when stimulated with the iNKT cell agonist α-galactosylceramide (αGalCer) in murine models. However iNKT cell based immunotherapies have proved disappointing in phase I and II clinical trials to date. Humans have a wider repertoire of CD1-restricted T cells compared to mice. These CD1 …
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Structural and Functional Studies of the Human Saposin Proteins
… the effective substrate-presenting particles in galactosylceramide hydrolysis. Finally, I compare the lipid interaction properties of the four saposins and address membrane perturbation, liposome binding, lipid solubilization and lipoprotein particle formation for each protein. Each saposin …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… These include fluorophore-appended 6”-amino-α-galactosylceramides and N-alkenoyl GSLs, such as PBS-57, a potent alphaGalCer surrogate useful in NKT cell stimulation studies. A nonantigenic beta-C-galactosylceramide has also been prepared as an inhibitor of these innate lymphocytes. To probe the …
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Lipid-coated micro- and nanoparticles as a biomimetic vaccine delivery platform
… of 2 ng antigen co-displayed on particles with c-galactosylceramide elicited measurable titers, and a prime-boost regimen of 2.5 ng ovaparticles adjuvanted with monophosphoryl lipid A elicited high titers that were sustained for >150 days. No studies to our knowledge have reported dose sparing to …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… and presentation of lipid antigens such as α-galactosylceramide (α-GalCer) to iNKT cells, producing a variety of anti-inflammatory (T\(_H\)2) cytokines, such as interleukin-4 (IL-4), and pro-inflammatory (T\(_H\)1) cytokines, such as interferon-γ (IFN-γ). A decreased number of iNKT cells and …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… positive for immature oligodendrocyte marker galactosylceramide (GalC) and mature oligodendrocyte marker myelin basic protein (MBP) in vitro, as well as the synthesis of myelin proteins. However, neither EVG or RAL induced cell loss or apoptosis, as determined by cell counts and TUNEL assays, …
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Protein-sphingolipid interactions and their role in immunity and disease
… proteins. I next asked whether AC processes galactosylceramide to psychosine, the cytotoxic GALC substrate accumulating in Krabbe disease, contributing to Krabbe disease pathology by increasing oligodendrocyte cell death. Surprisingly, I found that GALC knockout oligodendrocytes were not more …
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Structural analysis of glycolipid-derived oligosaccharides from metabolically radiolabelled colorectal carcinoma SW1116 cells
… fraction were, glucosylceramide (Glc-Cer), galactosylceramide(Gal-Cer), galabiosylceramide (Galαl-4Gal-Cer), lacto-N-tetraosylceramide (Galβ1-3GIcNAcβ1-3Galβ1-4Glc-Cer), Le<sup>a</sup>- pentaglycosylceramide (Galβ1-3[Fucal-4]GlcNAcβ1-3Galβ1-4Glc-Cer), HIpentaglycosylceramide …
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The Role Of Inflammation In Pathogenesis And Treatment Of Globoid-Cell Leukodystrophy
… in altered catabolism of the myelin lipid Galactosylceramide. The disease predominantly affects the white matter of the CNS and the myelin sheath of the peripheral nerves. The infantile form of the disease is characterized by early onset between 3-6 months of age with symptoms of …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… the absence of specific lipids, including galactosylceramide and sulfatide, and a generally low amount of gangliosides in both sub-populations, irrespective of confluence. Then, we studied the sphingolipid turnover in more detail using a metabolic labeling approach. Our results showed that …
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Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
<p>Human Papillomavirus (HPV) induced cancers continue to affect millions of women worldwide, with the five year survival rate hovering just under 60% in some demographics. Therefore there is an unmet need to develop effective, yet, easily administered therapies to treat established HPV genital …