Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"galactosylceramidase"”.
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The role of GPR65 and GALC in Multiple Sclerosis: Establishing the functional consequences of an MS associated variant on chromosome 14q31.3
… two protein coding genes; the lysosomal enzyme galactosylceramidase (GALC) and acid sensing surface receptor G-protein coupled receptor 65 (GPR65). In my thesis I attempted to validate and replicate this finding, and also to explore the possibility of other pH dependent effects of this SNP. In …
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The Role Of Inflammation In Pathogenesis And Treatment Of Globoid-Cell Leukodystrophy
… caused by a deficiency of the lysosomal enzyme galactosylceramidase: GALC). It results in altered catabolism of the myelin lipid Galactosylceramide. The disease predominantly affects the white matter of the CNS and the myelin sheath of the peripheral nerves. The infantile form of the disease is …
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Protein-sphingolipid interactions and their role in immunity and disease
Sphingolipids are a diverse class of lipids involved in fundamental cellular processes. In addition to their role in membrane architecture, sphingolipids can act as bioactive molecules, regulate membrane protein function and be presented to the immune system as lipid antigens by CD1 family …