Global ETD Search
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Showing 1 to 5 of 5 for “"galactofuranose"”.
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Methods for the Study of Galactofuranose in Mycobacteria
… over their more stable pyranose counterparts, galactofuranose is prevalent across nature from commensals to human pathogens. However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. Our knowledge about the biological …
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Role of β-galactofuranose and β-glucan in Aspergillus nidulans hyphal cell wall ultrastructure and physical properties
… nidulans hyphal cell wall. The sugar β-galactofuranose is a minor component of the cell wall and thought to be responsible for cross-linking of the other cell wall components, therefore responsible for maintaining cell wall structural integrity. We investigated the role of …
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Structural and mechanistic studies on eukaryotic UDP-galactopyranose mutases
Galactofuranose (Galf) is the five membered ring form of galactose. It is found on the cell wall and surface of many pathogens including Mycobacterium tuberculosis, Aspergillus fumigatus, Leishmania major, and Trypanosoma cruzi. Galf has been implicated in pathogenesis in these organisms; thus the …
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Structural Insights into Mycobacteriales Galactan Biosynthesis
… a 30-40 residue linear polysaccharide of galactofuranose (Galf) with an alternating β(1,5) and β(1,6) linkage pattern, synthesized by the polymerase Galactofuranosyl Transferase 2 (GlfT2). While GlfT2 has been established as a processive polymerase with intrinsic sequence control, the …
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
… mutase (UGM) is the sole source of the galactofuranose sugar that forms short crosslinks in the outer layer of galactomannan.<br/><br/>The underlying hypothesis is that gene deletion of A. fumigatus (i) plant-type chitinases, (ii) GNA1 and (iii) UGM produce distinctive biological …