Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"gag protein"”.
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
<p>APOBEC proteins have evolved in mice and humans as potent innate defences against retroviral infections. APOBEC3G (hA3G) in humans and mouse APOBEC3 (mA3) deaminate cytidine in single-stranded DNA which ultimately results in hypermutation of newly synthesized proviral DNA. Other …
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
<p>APOBEC proteins have evolved in mice and humans as potent innate defences against retroviral infections. APOBEC3G (hA3G) in humans and mouse APOBEC3 (mA3) deaminate cytidine in single-stranded DNA which ultimately results in hypermutation of newly synthesized proviral DNA. Other …
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
Glycosaminoglycans (GAGs) are a family of complex carbohydrates whose known biological roles have dramatically increased over the recent years. It is now becoming increasingly evident that sequence specific GAG-protein interactions play critical roles in cell growth, development, angiogenesis, …
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Determinanten und Mechanismen der foamyviralen Partikelfreisetzung
… zu den Orthoretroviren, die beiden strukturellen Proteine Gag und Env benötigen. Das Gag- Protein trägt alle für den Kapsidzusammenbau nötigen strukturellen Komponenten, kann jedoch durch eine fehlende Membranbindungsdomäne nicht mit Zellmembranen assoziieren. Der Membrantransport der bereits im …
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Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
… short peptide motifs within the structural Gag proteins that engage the cellular Class E vacuolar protein sorting (VPS) machinery. Three classes of late domains have been described in retroviruses, each with its own cellular interaction partners: PT/SAP domains bind Tsg101, LxxLF or YPXL …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
… of the 5 UTR intron produces an isoform of gag mRNA that is specialized for high translational efficiency. Further, evidence is provided for a novel branched secondary structure within the CGI that is important for HIV-2 replication. In addition, we show that mutation of the C-box alone can …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
… of the 5 UTR intron produces an isoform of gag mRNA that is specialized for high translational efficiency. Further, evidence is provided for a novel branched secondary structure within the CGI that is important for HIV-2 replication. In addition, we show that mutation of the C-box alone can …
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The Intracellular Kinetics of HIV-1 Replication
… by the presence of the MA domain of the Gag protein, is delayed precisely in order to allow restriction factor clearance to reach completion before the assembly process begins.
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Studies on rationally designed, allosteric, coagulation inhibitors
… approaches have failed to conquer the GAG-protein complexity. Computational analysis however could serve as a powerful approach to decipher this dilemma. A dual filter algorithm was incorporated to identify unique hexasaccharide sequences for HCII and AT. Our experimental studies …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… a 10-nucleotide palindrome sequence (pal; 5'-GGAGUGCUCC-3') of the 5'UTR, located within the major packaging signal, upstream of the dimerization signal (SL1: stem loop-1). Pal has been shown to interact intramolecularly with SL1 to inhibit SL1-mediated HIV-2 leader RNA dimerization in vitro. …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… a 10-nucleotide palindrome sequence (pal; 5'-GGAGUGCUCC-3') of the 5'UTR, located within the major packaging signal, upstream of the dimerization signal (SL1: stem loop-1). Pal has been shown to interact intramolecularly with SL1 to inhibit SL1-mediated HIV-2 leader RNA dimerization in vitro. …
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Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus
… The BLV full-length envelope (env) and gag genes were successfully sequenced from total DNA extracted from the blood of BLV-infected cattle from a single herd. The analyses indicated that the seven of the South African isolates characterised in this study belonged to genotype 4 and the …
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Untersuchungen zum Gag- und Pol-Protein des Prototypischen Foamyvirus (PFV)
… sich die Foamyviren (FV) bezüglich ihrer Proteinexpression, der Partikelmorphogenese und ihres Reproduktionszyklus deutlich von den Orthoretroviren. Im Rahmen dieser Arbeit wurden zwei exklusive Merkmale der Foamyviren, die ungewöhnliche Struktur des Gag-Proteins und die Gag unabhängige …
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A Novel HIV-1 Genomic RNA Packaging Element and its Role in Interplay between RNAPackaging and Gag-Pol Ribosomal Frameshifting
… the eukaryotic translational machinery for viral protein synthesis during infection of its target cells. In the cytoplasm, the unspliced version of retroviral RNA takes one of two pathways: 1) to serve as mRNA template for Gag protein translation, or 2) to act as genomic RNA that is packaged into …
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Proteomic Analyses of HIV-1 Infected T-cells and the Functional Characterization of Cyclophilin B During HIV-1 Infection
… and the virus interacts with many host cellular proteins for productive replication. Mass spectrometry analysis is a powerful tool to identify cellular proteins important for HIV replication and pathogenesis. Prior proteomic studies demonstrate that HIV-1 infection perturbs the host cell …
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Visualizing Protease Activation, Retrochmp3 Activity, and VPR Recruitment During HIV-1 Assembly
… virions, elucidated the mechanism by which the protein retroCHMP3 has an antiviral function, and examined the kinetics of recruitment of the HIV-1 accessory protein Vpr. I have also added significantly to science communication research through a study which evaluated the effectiveness of science …
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Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa: implications for HIV vaccine design
… candidate vaccine inserts based on the HIV-1 Gag protein from clades CDu422, CCH, A, B and D in 40 clade C-infected study participants using the IFN-γ ELISpot assay. To test the reactivity of group M consensus peptide reagents, 66 individuals, 44 of whom were ARV naïve, were assessed for …