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Showing 1 to 2 of 2 for “"gabazine"”.
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… titration in the presence of 10, 20, 40 µM of gabazine resulted in IC50s values of 20.1 (n=2), 37.17 (n=4), and 120.45 (n=2), respectively. In the presence of 20, 80, and 160 µM of TMPP (trimethylolpropane phosphate) the IC50s were 0.86 (n=2), 3.07 (n=3), 6.67 (n=2) µM, respectively. Increasing …
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Unique Response Properties and GABA<sub>A</sub> Receptor Function in Medial Geniculate Body Neurons of Young and Aged Fischer Brown Norway Rats
… (GABA<sub>A</sub>R agonist) activated a gabazine-sensitive (GABA<sub>A</sub>R antagonist) tonic current, providing support for the expression of functional high affinity GABA<sub>A</sub>Rs in the MGB. Activation of high affinity GABA<sub>A</sub>Rs expressed by MGB neurons decreased input …