Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"fviia"”.
-
The tissue factor-factor VII(a) complex in blood coagulation
… receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream where it comes into contact with FVII(a). The TF/FVIIa complex can be considered as a two-subunit enzyme: TF …
-
Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants
… the inhibition of thrombin, FXa, FIXa, and FVIIa in the presence and absence of antithrombin. CDs and FDs display a preference for direct inhibition of thrombin and FXa, and exhibit a high level of specificity over FIXa and FVIIa. In the presence of AT, CDs and FDs displayed weaker …
-
Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
… cascade is initiated when factor VIIa (fVIIa, other clotting factors are named similarly) binds to human tissue factor (TF), a 29 kDa integral membrane protein. The TF/fVIIa complex in turn activates fX and fIX, eventually concluding with clot formation. Several X-ray crystal structures …
-
Contribution of different types of phospholipids in blood coagulation
… and the crystal structures of GLA domains of fVIIa and fIX prepared in mixtures of these ions show occupation of two of these calcium binding sites with magnesium ions. Comparing rates of fX activation by cell surface complexes of tissue factor (TF) and factor VIIa (fVIIa) (or TF:fVIIa enzyme …
-
Plättchenassoziierter Tissue Factor als schnell aktivierbarer, intravaskulärer Starter des menschlichen Gerinnungssystems
… inaktiviert. TF kann damit zusammen mit FVIIa und FXa die Gerinnung starten. Die Ergebnisse lassen vermuten, dass die gesamte Blutgerinnung auf der Oberfläche von Plättchen stattfinden kann. Der intravaskuläre TF spielt vermutlicherweise eine Rolle bei der Aufrechterhaltung der Gerinnung …
-
Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… and recombinant clotting factors such as rFVIIa. However, the use of recombinant clotting factors is limited due to cost and adverse side effects resulting from increased thrombosis, such as increased rate of myocardial infarction and cerebrovascular accidents. Platelets are small anucleate …