Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"fusion peptide"”.
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THE ROLE OF CORONAVIRUS - HOST CELL MEMBRANE INTERACTIONS DURING VIRAL ENTRY AS MEDIATED BY CONSERVED REGIONS OF THE FUSION PEPTIDE
… Central to viral entry is the binding and fusion of the virus with the host cell membrane, a process orchestrated by the Spike (S) protein. Within the S, the fusion peptide (FP) is a short, highly conserved domain that inserts into the host membrane, initiating membrane fusion, genome …
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Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41)
Protein-mediated membrane fusion is an integral part of numerous cellular processes and viral entry. The HIV envelope glycoprotein mediates viral entry into target cells by fusing the viral envelope with the cell membrane. This process requires large-scale and multi-step conformational changes of …
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Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
… of a wide range of molecules, the hemagglutinin fusion peptide (HAfp), a small peptide that mediates the fusion process of the influenza virus to a host cell, and the T-cell immunoglobulin and mucin domain (Tim) proteins, involved in the mechanism of lipid recognition by T-cells.
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Cell penetrating peptide for ocular drug delivery
… is an intracellularly acting connexin mimetic peptide, said to be Cx43 HC specific without effecting cell-to-cell communication. Gap19, however, has low cell permeability. To improve cell uptake, Gap19 was fused with the cell penetrating peptide, Xentry, which specifically binds to cell surface …
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DECIPHERING THE MOLECULAR MECHANISM BEHIND THE SARS-COV-2 FUSION DOMAIN
… understood, particularly the process of membrane fusion. The traditional means by which viral glycoproteins facilitate fusion is that of the six-helix bundle, within which a short, conserved sequence known as the fusion domain (FD) initiates the process as it embeds within and perturbs the target …
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Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
… (Prostate Specific Membrane Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as a complementary linker to attach chemical moieties to siRNA. In Chapters 1 and 2, we introduced and discussed the background of prostate cancer chemotherapy, PSMA specific …
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Investigating the effects of pH on alphaviral E3-E2 glycoprotein association, organization, and cellular tropism
… the role of E3 is required in protecting the fusion peptide region of E1 during intracellular transport. Throughout viral processing, the association of E2 and E3 is required for the successful trafficking and incorporation of E1 into the mature virion. This E3-E2 association has been observed …
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Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule
… conjugated antigens. Orally delivered CTB or CTB fusion protein binds to G<sub>M1</sub>-ganglioside receptor molecules located on cells in the gutassociated lymphoid tissues, the site of immunological induction. We have generated transgenic plants synthesizing CTB conjugated with vaccine antigens …
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The effect of dissolved oxygen on recombinant protein degradation in Escherichia coli
… production of [alpha]1AT with an N-terminal OmpT fusion peptide. The yield of [alpha]1AT was influenced by elimination of cytoplasmic oxidoreductases that increased the redox potential of the cytoplasm, perhaps indicating an interaction between cellular redox status and the observed degradation …
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Genetics and functions of the SARS coronavirus spike protein
… spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. Investigations, described herein, have focused on the genetic manipulation of the SARS-CoV S glycoprotein in order to delineate functional domains within the protein. This was …
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Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
… 4, cholesterol was conjugated to a series of peptides composed of lysine and histidine residues. Our results indicate that the amphiphilic cholesteryl peptides can self-assemble to form a micelle-like structure in aqueous solutions. Formation of the micelle structure significantly promotes …
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Charakterisierung von reptilienpathogenen Paramyxoviren und Analyse des prokaryotisch exprimierten partiellen Fusionsgens
… closest relationship to the Sendai virus. The fusion (F) gene and protein of the reptilian paramyxovirus isolated from the snake Gonosoma oxycephala were also investigated. The sequences of the 1638 nt F gene and its 546 aa F protein were obtained and these sequences were compared to the F …
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Characterising the magnitude and breadth of T cell responses to SARS-CoV-2 vaccination
… as well as crude T cell breadth, using 7 peptide pools spanning the entire length of the spike protein at BL and 4 weeks (W4) post-vaccination. Boosting with mRNA-1273 resulted in a significant increase in the magnitude of spike-specific CD4 responses (median % memory CD4 T cells: 0.085 …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… to NOX inhibitor apocynin and the NOX fusion peptide inhibitor gp91ds-tat. Activation of ICl,swell induced by diazoxide, which stimulates mitochondrial ROS production by opening mitochondrial KATP channels, was not affected by gp91ds-tat. These data suggests that mitochondrial ROS is …