Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"fusion partners"”.
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Molecular Signatures of gastric cancer: An integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
… deletion associated with three chromosomal fusions. Among complex rearrangements, 18q21 was most frequently aberrant (35% of cell lines) with multiple fusion partners and sustained copy number loss in >50%. This 18q21q22 translocation was mirrored in 38% of 99 primary gastric cancer …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… can arise from the translocation-mediated fusion of the N terminus of the Mixed Lineage Leukemia (MLL) protein to various partner proteins. Although more than 60 different translocation-based fusion proteins have been identified, fusion partners such as AF9, AF10, and ENL constitute the …
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The effects of cis- and trans-acting mutations on recombinant protein secretion in Pichia pastoris
… -acting factors MATα secretion signal and MBP fusion partners, and trans-acting modifications such as the bgs mutants have increased heterologous protein secretion. Although these techniques have already been used, their effects on the protein secretory pathway have yet to be elucidated. In …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
… were used for 3D8 scFv fusion partners. Purified 3D8 scFv-OVA fusion proteins with ~95% purity retained DNA-binding, DNA-hydrolyzing, cell-penetrating, and cytotoxic activity comparable to 3D8 scFv. Although 3D8-OVA proteins induced B16 and MO5 melanoma cancer cell death …
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Significance of Protein Interactions in Mediating AF9 Function
… to the C-terminal portion of over 50 different fusion partners. The chimeric proteins cause constitutive expression of some MLL target genes such as HOXA9 and MEIS1, and enhanced proliferation of hematopoietic progenitors. MLL chimeras do not retain the histone methyltransferase activity of wild …
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Chlorinated amino acids in peptide production
… or sensitive external agents. When encoded in a fusion protein, the chlorinated residues can be used for rapid separation of the fusion partners. The utility of the method was demonstrated through the preparation of small peptides human gastrin releasing peptide prohormone, cholecystokinin …
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Chlorinated amino acids in peptide production
… or sensitive external agents. When encoded in a fusion protein, the chlorinated residues can be used for rapid separation of the fusion partners. The utility of the method was demonstrated through the preparation of small peptides human gastrin releasing peptide prohormone, cholecystokinin …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… B/myeloid mixed phenotype acute leukemia. These fusions juxtapose full-length ZNF384 to the N terminal portion of a diverse range of partners, most often, transcription factors or epigenetic modifiers. It has been shown that ZNF384-rearranged tumors have a distinct gene expression profile that is …
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Applications of yeast display in synthetic biology with a focus on biological synthesis and recycling of plastics
… of signal peptides (SPs) and translational fusion partners (TFPs) to optimise surface display of a protein of interest – a significant challenge for many recombinant proteins. This expansion of the MoClo-YTK yeast was validated using several proteins of interest and constitutes a yeast …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… lymphoid leukaemias. Despite having more than 80 fusion partners, MLL-AF9, MLL-AF4 and MLL-ENL make up more than 60% of cases involving *MLL1* translocations. Conventional retroviral transduction models commonly use lineage depleted or c-Kit enriched mouse bone marrow haematopoietic stem and …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… or inversions have involved different fusion partners, which create novel fusion proteins that facilitate autophosphorylation of ALK, resulting in a constitutively active tyrosine kinase with oncogenic potential. ALK fusion proteins enable transcriptional programmes that drive the …