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Showing 1 to 20 of 30 for “"fused-ring"”.
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Chemistry of fused-ring iridabenzenes
… this class. However, examples where additional fused rings are attached to the metallabenzene core are scarce and the chemistry of these `fused-ring metallabenzenes' is only just beginning to be explored. The work described herein sought to contribute to our understanding of these intriguing …
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High Pressure Studies of Fused Ring Aromatic Complexes
Made available in DSpace on 2014-12-08T23:18:07Z (GMT). No. of bitstreams: 1 6507073.pdf: 4492228 bytes, checksum: 5e22582e5f5d015fa7382e866a585afe (MD5) Previous issue date: 1965
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Exploration of Synthetic Pathways to Quaternary Carbon Stereocenters and Fused Ring Systems via Birch Reductions
<p>The Birch reduction – alkylation is an effective way to form all-carbon quaternary centers from inexpensive commercially available starting material. When coupled to complementary reactions such as the Rauhut-Currier or Mizoroki-Heck, complex drug-like structures can be rapidly formed. We have …
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On-Metal Synthesis of Some Aryl Substituted Rhenium η<sup>5</sup> Cyclopenta[C] Pyridazyl Complexes
… complexes for polymer research. SeveraI5,6-fused ring pyridazines (1,2-CsH3(CRNH)(CRN) have been synthesized and characterized. Additionally, pyridazyl complexes of rhenium were synthesized in three steps beginning from fulvenes 1,2-CsH3(COHR)(COR). On-Metal synthesis and characterization of …
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Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.
… benzosuberene analogues incorporate a [6,7] fused ring system with an aryl ring attached at the 5-position. The initial discovery in the Pinney Research Group of the benzosuberene lead compound 1-hydroxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene 1, has led to research …
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X-ray structural investigations of bromo-oxoditerpenoids and the nickel (II) chelate of a pyridoxal-amino acid intermediate
… by the attachment of two Schiff base units. The fused ring system of each unit reveals distortions from planarity.
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Novel Materials for Use in Homeland Security Research
… fulvenes were treated with hydrazine hydrate to ring close to pyridazines. Next, the pyridazines were converted to their respective thallium salts through treatment with thallium (I) ethoxide. Lastly, the salts were transmetallated into the respective rhenium or manganese complexes through …
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Off-Metal Synthesis of Some Aryl Substituted Rhenium n5-Cyclopenta [C] Pyridazyl Complexes
… material. Pyridazines, 6-membered aromatic rings with two adjacent nitrogens, are promising candidates for a variety of materials and commercial applications. These molecular electronic materials posses several advantages over traditional inorganic semiconducting materials including lower …
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Intramolecular (4+2); and tandem intermolecular (4+2);/intramolecular (3+2); cycloaddition of nitroalkenes with achiral and chiral dienophiles
… methylene units to a Z-dienophile afforded trans fused nitronates. The cycloaddition towards larger rings were unsuccessful. Cyclic dienophiles cyclized to form fused ring nitronates with extremely high selectivity. The ring fusion between the carbocycles was dependent on the ring size of the …
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Synthesis and Characterization of Manganese Pyridazyl Complexes
<p>Heterocyclic’s and their fused-ring derivatives have been of interest for their use in electronic materials due to their ease of production, synthetic versatility, and low cost compared to traditional inorganic materials like silicon. Pyridazines have been found to be useful in catalysis gas …
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Cascade Approaches to Polycyclic Natural Products
… of considerable difficulty, such as rigid fused-ring systems and quaternary chiral centers, has been applied to the chosen molecules. The results of these studies have demonstrated the power of cascade-based core formation to rapidly assemble complex, polycyclic architectures in two …
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Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.
… The skeletal structure of flavonoids is a fused ring system modified by hydroxyl, sugar, and carbohydrate additions. Flavone is a structurally simple flavonoid. Quercetin and its glycosidic analog rutin are complex structures. Using a DNA oxidation/cleavage assay, flavone reduces DNA …
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Synthesis and Structure of a Substituted Pyridazine
… heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that …
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Synthesis and Characterization of some Thallium Salt Complexes
… a library of chloro-phenyl based fulvenes, 5,6 fused ring pyridazines, and thallium Cp salts have successfully been synthesized. Research is currently underway to synthesize rhenium and manganese pyridazines through transmetalation of the thallium salts. The off-metal route of synthesis was …
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Studies towards Selective Synthesis of Resveratrol-based Oligomeric Natural Products
… key common intermediate possessing three aryl rings. Syntheses of three subclasses of resveratrol dimeric structures are reported. 𝘊𝘩𝘢𝘱𝘵𝘦𝘳 3. 𝘚𝘺𝘯𝘵𝘩𝘦𝘵𝘪𝘤 𝘦𝘧𝘧𝘰𝘳𝘵𝘴 𝘵𝘰𝘸𝘢𝘳𝘥𝘴 𝘥𝘪𝘩𝘺𝘥𝘳𝘰𝘣𝘦𝘯𝘻𝘰𝘧𝘶𝘳𝘢𝘯-𝘤𝘰𝘯𝘵𝘢𝘪𝘯𝘪𝘯𝘨 𝘩𝘪𝘨𝘩𝘦𝘳 𝘰𝘳𝘥𝘦𝘳 𝘳𝘦𝘴𝘷𝘦𝘳𝘢𝘵𝘳𝘰𝘭 𝘰𝘭𝘪𝘨𝘰𝘮𝘦𝘳𝘴. Finally, this chapter describes our current studies towards …
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Structural and synthetic studies of bioactive natural products
… show DNA damaging activity, and possess a novel fused ring system. The bioactive sterols ergosta-5-24(28)-diene-3β,7α-diol [3.1] and 24,28- epoxyergost-5-ene-3β,7α-diol [3.2], originally isolated from <i>Pseudobersama mossambicensis</i>, have been synthesized from stigmasterol. In addition to …
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A dimensional analysis of the benzylic hydroxylase active site in mortierella isabellina
… in both directions in the plane of the aromatic ring of 7.3 Angstroms for the depth and 7.1 Angstroms for the width. A minimum requirement for the height of this region has also been established at 6.2 Angstroms. The region containing the active oxygen species was also investigated, using a …
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Antiviral Agents: 3,5-Disubstituted 1,2,4-Oxadiazole Derivatives and Novel Peptidomimetics Containing Hydroxyethyl Isostere and Imidazolidinone Structures
… of a small library of derivatives exploring possible optimization of the <b>A3</b> scaffold. The presence of an indole moiety is seen as a main reason for stability issues with the lead compound. Therefore, the second goal is the finding of a suitable bioisosteric replacement for this …
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Carbene catalyzed asymmetric nucleophilic acylations with novel triazolium salts
… has benefited from the expected impact of the fused ring, N-based substituent and nature of the side chain steric demand. Finally, after screening different conditions, we were able to obtain the 1,4 diketones in moderate to excellent yields (49 98%) and moderate to good enantioselectivities …
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Development of New Computational Approaches to Predict the UV-Vis Behavior of Charge Transfer Organic Dyes and Application to Novel Silole Containing Dyes
… the TD-DFT predictions. This was done by considering half the energy difference between the unoccupied orbital predicted by TD-DFT and a higher energy unoccupied orbital that overlaps with the occupied orbital predicted by TD-DFT. This method was used to predict the UV-Vis absorbance spectra of …
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