Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 100 for “"furan"”.
-
Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
-
A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones
Many important natural products contain the furan-2(5H)-one structure. The structure of this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents. By developing different reaction schemes at the …
-
SÍNTESE DE NOVOS DERIVADOS DE LAPACHONAS E NOR-LAPACHONAS: VEREDAS À ATIVIDADE FARMACOLÓGICA
In the present work the reactivity of orto-furan-naphthoquinones, para-furannaphthoquinones and para-piran-naphthoquinones was studied, in order to produce new pharmacological prototype compounds. Eighteen novel naphthoquinones were prepared. The orto-furan-naphthoquinones …
-
Sorption mechanisms of dibenzo-p-dioxin/furan from water by smectite clays and theoretical studies on formation pathways of chlorodibenzo-p-dioxins from precursor chlorophenols on smectite clays
… effectively adsorbed dibenzo-p-dioxin /furan from water. Adsorption was promoted by exchangeable cations with low hydration energies, and negative charge in the smectite arising from the tetrahedral siloxane sheets. X-ray diffraction measurements revealed that as dibenzo-p-dioxin (DD) …
-
Structural and synthetic studies of bioactive natural products
… 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b ]furan-4,9-dione [2.13], 2-(1 '-hydroxyethyl)naphtho[2,3-b ]furan-4,9-dione [2.14]' 2-isopropenylnaphtho[ 2,3-b ]furan-4,9-dione [2.15], 5-hydroxydehydro-iso-a-Iapachone [2.16], 3-hydroxymethylfuro[3,2-b ]naphtho[2,3-d]furan-5,10-dione [2.17], and 9- …
-
The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
A series of furan analogs were prepared bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular …
-
Synthesis and cycloaddition chemistry 1,3-Bis(phenylsulfonyl)propadiene
… and with tetrahydrofuran to yield 2-(2-tetrahydrofuranyl)-(E)-1 ,3-bis(phenylsulfonyl)propene, in a novel insertion reaction. The homocyclisation of 1,3-bis(phenylsulfonyl)propadiene under thermal conditions was demonstrated to yield the highly substituted 2,7bis( …
-
Keteneylidenetriphenylphosphorane as a 'C2O building block' in the synthesis of highly functionalised tetramic and tetronic acids
… 4-hydroxy-pyrrol-2(5H)-ones and 4-hydroxy-furan-2(5H)-ones are known to possess a wide range of biological activities such as anti-viral and tumour inhibition. For this reason, the synthesis of a number of these compounds was attempted, namely Tenuazonic Acid, Reutericyclin and Carlosic …
-
Reaktivität silylierter und stannylierter π-Systeme
… Einfluss von 2-Silyl- und 2-Stannylgruppen auf Furane und Thiophene (7- 10, 16, 19, 23) wurde am Beispiel der Umsetzungen mit Benzhydrylkationen 26a-d untersucht (Schema 0.1). Während die Umsetzungen der Benzhydryltriflate mit 2-(Trimethylsilyl)furan (7) und -thiophen (19) ein Gemisch von 27/35 …
-
The photochemistry of 2,4- and 2,6-cyclo-octadienone
… by an unambiguous route. In methanol and furan, however, capture of a reactive intermediate in the photolysis occurred much more rapidly than intramolecular rearrangement. This reactive intermediate was detected by using low temperature photolysis techniques to involve a strained ground …
-
Investigation of Volatile Products from Wood Pyrolysis
… and releases gaseous products including furan derivatives that are useful as fuels or fuel additives. The sulfuric acid (10%) pretreatment of wood followed by slow pyrolysis produced maximum yield of charcoal, indicated by the lowest mass % decrease of 58.234. The production of furan …
-
In vitro Untersuchungen zur Wirkung von Saccharidmimetika auf verschiedene Schritte der Metastasierung von malignen Melanomzellen
… Adhäsionsversuche mit digalactosylierten Furan-Derivaten, welche in äquivalenter Konzentration in der Lage waren die Adhäsion der B16F10-Zellen an Fibronectin (40 %), Vitronectin (50 %) und Laminin (50 %) signifikant zu reduzieren. Der Furanring als Grundgerüst der Saccharidbibliothek …
-
Characterization and Chemical Kinetic Analysis of the Ignition of Representative Conventional and Bio-Derived Fuels
… especially in the transportation sector. Furans, a class of biofuels, are considered as possible alternative fuels for SI engines. They can be produced from sugars, derived from non-food biomass sources. This thesis is a contribution to fundamental characterization of their combustion …
-
An Investigation of Gold(I) Catalyzed Cycloaddition Reactions
… 13- and 15-membered macrocycles containing furan and α-chloroketone functional groups were synthesized. Macrocycles were subjected to solvent mixture (Et<sub>3</sub>N, CF<sub>3</sub>CH<sub>2</sub>OH, and Et<sub>2</sub>O), and an oxyallyl cation was presumably formed, which proceeded to react …
-
Synthesis of a renewable sourced thermotropic polyester with 2,5-furandicarboxylic acid
… biobased materials grows ever more desperate. Furan derivatives sourced from hexoses provide a promising solution for replacing petrochemical based materials. One furan derivative in particular, 2,5-furandicarboxylic acid (FDCA), is especially promising due to its structural similarity to …
-
Fused and spiro furanones from tetronic acid synthons: Oxa and azacycles featuring the butenolide ring
… produced the corresponding spiro cyclopropane furan-2,4-diones. Nucleophilic ring opening with diverse alcohols converted the spiro cyclopropane furan-2,4-diones to 3-beta-alkyloxypropyltetronic acids. When using O-benzyl isourea for the 4-O-alkylation of 3-allyl tetronic acids, the 3-benzyl …
-
Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… of the molecule we wish to focus on is the furan ring. Our routes to Salvinorin A were designed to allow for changes to be made to the section of the molecule where the furan is ring late in the synthesis. Part II: West-Nile Virus (WNV) and Dengue Virus (DENV), both members of the …
-
Scope of enantioselective reduction of imines with trichlorosilane
… %), dependence on position isomer was observed: furan-2-yl-derived substrates were reduced in moderate enantioselectivity (45-85 % ee), possibly due to the problem of coordination; in contrast, furan-3-yl derivatives were reduced in good enantioselectivity (77-91 % ee). 4. Non-heterocyclic …
-
The synthesis and evaluation of small organic molecules as cholecystokinin antagonists
… equally active. A number of existing and novel furan- 2(SH)-one building blocks were prepared, from which a selected mini-library of 4- amino-substituted furan-2(SH)-ones were prepared and evaluated. All synthesised compounds were evaluated in a CCK radiolabelled binding assay (CCKA & CCKB), …
Page 1 of 5