Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"fungal cell wall"”.
-
Peering into Candida albicans pir protein function
The fungal cell wall, which primarily is comprised of protein and polymeric carbohydrate, maintains cell structure and protects the fungal cell from the environment. Cell wall structure is an avid field of study because the cell wall is an important antifungal drug target. Pir proteins (proteins …
-
LPS, A TLR-4 AGONIST AND VIPER A TLR-4 INHIBITOR UPREGULATE PHAGOCYTOSIS OF ZYMOSAN IN BV2 CELLS
<p>Microglia cells are the first line of innate immunity defense in the central nervous system (CNS). They play a critical role in maintaining CNS homeostasis by having an active but yet balanced phagocytic activity. However, in various CNS related diseases, microglia cells have been shown to …
-
Raman and SERS studies of filamentous fungi
Fungal species perform many important roles in biotechnology and recycling and act as agents of disease and decay. Surface-enhanced Raman scattering (SERS) has attracted significant attention as an analytical method for chemical and biological identification. For SERS experiments, it is essential …
-
Molecular Biophysics of Mammalian and Fungal Macromolecular Assemblies
… study of the macromolecular architecture of the fungal cell wall belonging to the virulent fungal species <em>Cryptococcus neoformans</em>, of which the goal was to obtain biochemical and biophysical insight into the macromolecular complexes involved in human infections, while also potentially …
-
Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… has emerged as one of the most common airborne fungal pathogens in recent decades. In immunosuppressed patients, inhalation of <i>A. fumigatus</i> spores can initiate life-threatening invasive aspergillosis (IA) with mortality rates up to 90%. The high mortality is largely due to a limited …
-
Variable Tnf-α Production By Murine Macrophages to a Cell Wall Extract of Candida Albicans
… α (TNF-α). Since mannan is a component of the fungal cell wall that has been indentified as an important virulence factor in the pathogenicity of C. albicans, we examined its ability to stimulate macrophages to produce TNF-α. Mannan was extracted from the yeast phase of C. albicans, purified, …
-
A comparative study of in vitro chitin synthase activity in mucoraceous hosts of a mycoparasite
… responsible for the synthesis of chitin in fungal cell wall was extracted from young hyphae of Choanephora cucurbitarum and Phascolomyces articulosus, susceptible and resistant hosts, respectively, to the mycoparasite, Piptocephalis virginiana. Crude enzyme was identified and characterized …
-
Analysis of the role of velvet and laeA in the molecular interactions between grass and Epichloë fungal symbionts
… LaeA are two wellknown regulators of different fungal development and metabolic processes. Some of these include fungal cell wall characteristics and hyphal morphology that have been previously implicated as important for compatible interaction between Epichloë and grasses. In addition they …
-
Molecular mechanisms of stress tolerance in plants
… a positive effect of chitin (released from the fungal cell wall) on salinity tolerance. In Chapter 3, we explore the cross talk between salt stress and chitin-triggered immune responses. Our results demonstrate a physiological and biochemical link between salinity stress and chitin-triggered …
-
Role of β-galactofuranose and β-glucan in Aspergillus nidulans hyphal cell wall ultrastructure and physical properties
The fungal cell wall is a first line of defence from the external environment or chemical treatments. Glucan, chitin and mannan are the main components of the Aspergillus nidulans hyphal cell wall. The sugar β-galactofuranose is a minor component of the cell wall and thought to be responsible for …
-
Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… airways, FOXA2 is inactivated in both club cells and ciliated cells, resulting in the differentiation of these pluripotent airway cells into the mucin secreting goblet cells. Mucin-containing mucus layer protects airways from inhaled microbes and irritants. Albeit its protective roles, …
-
Responses to Antifungal and Alkaline pH Stress in Human Fungal Pathogens
<p>The fungal pathogens encounter ever-changing conditions during their pathogenic life cycles, including shifts from the environment to the human host. Fungi have evolved many pathways that allow them to overcome and even thrive in the presence of the stresses presented by different …
-
Production and characterization of the recombinant wheat chitinase Wch1 and generation of chitin-specific antibodies
… polymer and were able to bind to the hyphal cell walls of F. graminearum as demonstrated by immunofluorescence microscopy assay. Surprisingly, both antibodies displayed a complete loss of binding capacity towards the polymer but not toward the peptide after affinity purification. This result …
-
The <i>C. neoformans</i> Cell Wall: A Scaffold for Virulence
… is a globally distributed opportunistic fungal pathogen and the causative agent of life threatening cryptococcal meningoencephalitis in immunocompromised individuals, resulting in ~180,000 deaths each year worldwide. A primary virulence-associated trait of this organism is the production …