Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"functionalized nanoparticles"”.
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Functionalized Nanoparticles for Targeted Chemotherapy [Nanoparticelle funzionalizzate per terapie targat]
In questo lavoro è sono stati esplorati lo sviluppo e la modifica della superficie di varie nanoparticelle per imaging e ldrug-delivery; l'obiettivo è quello di migliorare la specificità e l'efficacia dei trattamenti, riducendo gli effetti collaterali e migliorando l'aspettativa di vita dei …
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Particle assisted protein crystal nucleation as a protein purification platform for pharmaceutical manufacturing
… manufacturing. This work investigates the use of functionalized nanoparticles in solution to act as in situ templates for initiating crystal nucleation. We used lysozyme, a protein with well-characterized crystallization conditions, to evaluate the nucleation rates of crystals grown on the …
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Conformational investigations of a model polyzwitterion and its applications in oil recovery
In recent years, nanoparticles have demonstrated immense promise for the development of next generation technologies for subsurface reservoir characterization and oil recovery. Until now however, the scope of such nanoparticles has been limited due to the significant challenge of colloidal …
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
… were activated by CpG oligonucleotide- and siRNA-functionalized nanoparticles [approx.]10-fold more potently than by soluble CpG or siRNA ligands.
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Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles: Degradable Polyphosphoesters and Anisotropic Distribution of Chemical Functionalities
… research included two kinds of asymmetrically-functionalized nanoparticles with anisotropic distributions of chemical functionalities, three degradable polymers synthesized by organocatalyzed ring-opening polymerizations, and two polyphosphoester-based nanoparticle systems for various …
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Electronic properties of phenylated ligand-capped nanoparticle films
… films comprised of phenylated ligand-capped gold nanoparticles. In homoligand-type films, the dominant mechanism of charge transfer was expected to involve orbital overlap and end group-effected wave function displacement, whereas heteroligand-type films were expected to conduct through less …
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Optimizing the Toehold-Mediated Strand Displacement Reaction on the Nanoparticle Surface by Altering the Surface DNA Density for the Design of a microRNA NanoOptical Sensor
… of aggregation and disassembly processes of DNA-functionalized nanoparticles. Specifically, we examine factors influencing the toehold strand-displacement reaction on nanoparticle surfaces. Gold nanoparticles were functionalized with oligonucleotide sequences with varying surface density by …
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Towards Colloidal Self-Assembly for Functional Materials
… and electrochemical applications at scale. DNA-functionalized nanoparticles are versatile models for exploring colloidal self-assembly due to the highly specific, tunable and thermally reversible binding between DNA strands. Gold nanoparticles coated with DNA were used to investigate the …
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SERS-active peptide nanoparticles for investigating protein allostery and bionanoassembly
… (Surface enhanced Raman scattering) - active nanoparticles, functionalized with a p53 peptide mimic, peptide 12.1, display biologically specific aggregation following addition of MDM2. The extent of nanoparticle assembly is altered following the introduction of various MDM2 binding ligands. …
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Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis
… and discusses potential of colloidal iron oxide nanoparticles as non-toxic MRI contrast agents for diagnosis. Novel single-nanometer iron oxide (SNIO) nanoparticles exhibited contrast enhancement in T1-weighted MRI superior than commercially used gadolinium-based contrast agents, with …
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Programmable Microparticle Scaffolds for Enhanced Diagnostic Devices
… proteins to either anchor the cells, bind to functionalized nanoparticles, or capture small molecules from the environment, all complex actuation features. Additionally, we have created a processing unit that can create signals based on biological components, yet is non-living. This thesis …
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A study of functionalized iron oxide nanoparticles for selective recognition of kappa-casein: a breast cancer biomarker.
… detection of breast cancer. In this research, functionalized iron oxide (Fe3O4) nanoparticles were used for selective recognition of kappa casein (kcn) a breast cancer biomarker. The Fe3O4 was synthesized by the co-precipitation method. The particles were then coated with a polyacrylamide film …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… of this study are twofold: 1) develop and test functionalized nanoparticles to eliminate biofilm bacteria and, 2) to stabilize and strengthen the dentin organic matrix by crosslinking collagen fibrils in the presence of biopolymeric nanoparticles. A bioactive polymeric nanoparticle …
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Nano-based drug delivery systems: Targeting to corticospinal tract neurons for controlled release of therapeutics
… CNS cellular diversity. We suggest using surface functionalized nanoparticles (SFNPs) to specifically target particular neurons and deliver regeneration-encouraging drugs in a remotely actuation-able and controlled manner. We have developed fluorescently labeled polyethylene glycol (PEG) copolymer …
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Implications of Shape Factors on Fate, Uptake, and Nanotoxicity of Gold Nanomaterials
Noble metal nanoparticles such as gold and silver are of interest because of the unique electro-optical properties (e.g., localized surface plasmon resonance [LSPR]) that originate from the collective behavior of their surface electrons. These nanoparticles are commonly developed and used for …
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Nanoparticles for Simultaneous Assessment of Ros and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes
… This is due to the ability of specific nanoparticles (NPs) to increase local physical dose deposition and subsequent, direct damage to cells and DNA within their local vicinity. High electron density and atomic number NPs act both as a radiosensitizers and radioenhancers with high …
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Polystyrene coated iron-platinum drug delivery platforms for theranostics
… both therapeutic and diagnostic applications.2,3 nanoparticles have been shown to passively accumulate in tumors, making them useful materials for developments in cancer research.4 Iron-platinum (FePt) nanoparticles have an excellent potential as delivery agents for medicinal applications. …
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