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Showing 1 to 1 of 1 for “"functionalisation of ketones"”.
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Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
The development of a palladium-catalysed C–H carbonylation of hindered secondary amines is described. Central to this strategy is the temporary conversion of simple ketones into hindered secondary amines that facilitates a sterically promoted palladium-catalysed C–H activation. A range of …